Fibulin-3 fragments are prognostic biomarkers of osteoarthritis incidence in overweight and obese women

Runhaar, Jos; Sanchez, Christelle; Taralla, Sébastien; Henrotin, Yves; Bierma-Zeinstra, Sita M A

doi:10.1016/j.joca.2015.10.013

Cited by 25 publications

(23 citation statements)

References 24 publications

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“…While the role of fibulin-3 in osteoarthritis is still unknown, a recent study by Henrotin et al suggests that Fib3-1 and Fib3-2 are potential diagnostic biomarkers of OA, demonstrating that serum levels of Fib3-1 and Fib3-2 in severe knee OA patients are higher than those in healthy controls [40]. Moreover, investigating middle-aged, overweight and obese women, Runhaar et al indicated that Fib3-1 correlates with the incidence of radiographic knee OA defined by American College of Rheumatology (ACR) criteria and chronic pain at 30 months of follow-up [41]. …”

Section: Biomarkers For Cartilage Bone and Synovium Metabolismmentioning

confidence: 99%

Review of Prospects of Biological Fluid Biomarkers in Osteoarthritis

Nguyen

Sharma

Chakraborty

et al. 2017

IJMS

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Osteoarthritis (OA) is a degenerative disease of the joints and is one of the leading causes of disability in adults. However, there are no key therapeutics for OA and medical treatment is based on managing the symptoms and slowing down progression of the disease. Diagnostics based on clinical examination and radiography have provided little information about metabolic changes in joint tissues, disease onset and progression. Due to lack of effective methods for early detection and evaluation of treatment outcome, the measurement of biochemical markers (biomarkers) shows promise as a prospective method aiding in disease monitoring. OA biomarkers that are present in biological fluids such as blood, urine and synovial fluid, sources that are easily isolated from body, are of particular interest. Moreover, there are increasingly more studies identifying and developing new biomarkers for OA. In this review, efforts have been made to summarize the biomarkers that have been reported in recent studies on patients. We also tried to classify biomarkers according to tissue metabolism (bone, cartilage and synovial metabolism markers), pathological pathways (inflammatory and genetic markers) and biological function (chemokines, growth factors, acute phase proteins, etc.).

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Section: Biomarkers For Cartilage Bone and Synovium Metabolismmentioning

confidence: 99%

Review of Prospects of Biological Fluid Biomarkers in Osteoarthritis

Nguyen

Sharma

Chakraborty

et al. 2017

IJMS

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“…The latest research shows that miRNA has a close relationship with a variety of physiological and pathological conditions. The present study suggests that miRNA is associated with the occurrence, development and prognosis of cancer, which can be used as a molecular marker of cancer [12,13]. For example, microrna-18a is a molecular marker of prostate cancer [5]; microRNA 25, microRNA 145 and microRNA 210 are molecular markers of liver cancer.…”

Section: Introductionmentioning

confidence: 73%

Study on the clinical value of miRNA98b as a potential biomarker for osteoarthritis

Wang¹,

Ma²,

Xu³

et al. 2018

biomedicalresearch

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Objective: Osteoarthritis is a serious threat to the health of patients. Biomarkers have important significance in the diagnosis of bone arthritis. Bone mineral density is one of the important indicators for the detection of bone joint inflammation, but its detection is time-consuming and laborious. MicroRNA regulates cancer and inflammation. This study was to investigate the potential value of biomarkers miRNA98b in the diagnosis of early osteoarthritis. Methods: 69 cases of patients with osteoarthritis and 69 cases of healthy volunteers were regarded as research objects. Etidronate disodium had been continuously administrated for 4 w. The patient's bone density reached to the normal value which was regarded as effectiveness of the treatment. The miRNA98b level before and after therapy in blood cells of patients with osteoarthritis and healthy volunteers was detected by real time RT-PCR. The correlation between miRNA98b levels and osteoarthritis was analysed. Results: mRNA level of miRNA98b in blood cells of patients with osteoarthritis was higher than that of healthy volunteers. After being continuously administrated for 2 w, mRNA of miRNA98b in blood cells decreased, there was no significant change in the level of miRNA98b in blood cells of healthy volunteers. The level of miRNA98b in the blood cells of patients with severe osteoarthritis is higher than that in the blood cells of patients with general osteoarthritis, the difference was statistically significant (P<0.05). The level of miRNA98b in the blood cells of patients with osteoarthritis has a positive correlation with the severity of osteoarthritis. Conclusion: MiRNA98b in blood cells of patients with osteoarthritis may be a potential biomarker for osteoarthritis. The level of miRNA98b was correlated with the severity of osteoarthritis.

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“…Participants were excluded if they had any of the following: lack of motivation to lose weight, inability to speak Danish, planned anti-obesity surgery, total knee alloplasty (TKA), or receiving pharmacologic therapy for obesity. The patients were given an initial 16 week intensive diet intervention in a supervised program, inducing a clinically significant weight loss. The intensive diet intervention consisted of 8 weeks of full meal replacement (Cambridge Weight Plan TM, Northants, UK) with either 810 or 415 kcal/day followed by 8 weeks with gradual reintroduction of "normal food" in a hypo-energetic diet of 1200 kcal/day 21 .…”

Section: Studymentioning

confidence: 99%

“…We analysed the changes from week 0 using repeated measures mixed effects models, allowing for imbalanced data (i.e., no imputation for missing data beyond baseline) with maintenance group (Control, Diet, and Exercise) and week (8,16, and 68) as fixed effects including their interaction, and participant as random effects. The models were adjusted for the baseline value.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…Another suggested marker for OA activity is Fibulin3 turnover measured by the Fibulin3 fragment Fib3-2, which is raised in OA compared to healthy individuals 15,16 . Fibulins are glycoproteins present in extracellular matrix 17 in many parts of the body like the walls of smaller blood vessels, in basal membranes, myofascia, and cartilage 17e19 .…”

Section: Introductionmentioning

confidence: 99%

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