Effectiveness of 8- and 12-Week Treatment with Ombitasvir/ Paritaprevir/Ritonavir and Dasabuvir in Treatment-Naïve HCV Patients in a Real-Life Setting in Romania: the AMETHYST Study

Trifan, Anca; Stanciu, C; Iliescu, Laura; Sporea, Ioan; Baroiu, Liliana; Diculescu, Mircea; Luca, M. De; Miftode, Egidia; Cijevschi, Cristina; Craiu, Mihai; Sparchez, Zeno-Adrian; Pojoga, Cristina; Streinu-Cercel, Adrian; Gheorghe, L.

doi:10.15403/jgld-3373

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…Like telaprevir, ombitasvir (133), another antiviral medication, is used as a combination therapy to treat chronic hepatitis C. This molecule inhibits, more specifically, NS5A, a protein essential for viral replication and virion manifestation. This analog also acts as a potent inhibitor of SARS-CoV-2 [187].…”

Section: Pyrrolidine Derivativesmentioning

confidence: 99%

N-Heterocycles as Promising Antiviral Agents: A Comprehensive Overview

Ahmad,

Sohail,

Bilal

et al. 2024

Molecules

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Viruses are a real threat to every organism at any stage of life leading to extensive infections and casualties. N-heterocycles can affect the viral life cycle at many points, including viral entrance into host cells, viral genome replication, and the production of novel viral species. Certain N-heterocycles can also stimulate the host’s immune system, producing antiviral cytokines and chemokines that can stop the reproduction of viruses. This review focused on recent five- or six-membered synthetic N-heterocyclic molecules showing antiviral activity through SAR analyses. The review will assist in identifying robust scaffolds that might be utilized to create effective antiviral drugs with either no or few side effects.

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Section: Pyrrolidine Derivativesmentioning

confidence: 99%

N-Heterocycles as Promising Antiviral Agents: A Comprehensive Overview

Ahmad,

Sohail,

Bilal

et al. 2024

Molecules

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show abstract

“…Chronic viral hepatitis was shown to be a negative prognostic factor in patients with COVID-19. A meta-analysis of 257 patients with COVID-19 of which 235 with chronic hepatitis B and 22 patients with chronic hepatitis C scoring a 6% death rate in those with HBV and 13 % in those with HCV, the transfer rate in the ICU 14.1% in HBV and 21.4% in HCV, significantly increased compared to patients without chronic viral hepatitis[ 58 , 59 ].…”

Section: The Impact Of Covid-19 On Liver With Pre-existing Chronic Injurymentioning

confidence: 99%

COVID-19 impact on the liver

Baroiu¹,

Dumitru²,

Iancu³

et al. 2021

WJCC

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The coronavirus disease 2019 (COVID-19) pandemic imposed arestructuring of global health systems by rethinking spaces used for the care of these patients and the additions of intensive care, infectious diseases and pneumology departments. This paper provides evidence on the presence of severe acute respiratory syndrome coronavirus 2 in hepatocytes and its direct cytopathic activity, as well as the degree of liver damage due to drug toxicity, inflammation and hypoxia in COVID-19. A review of clinical trials has quantified liver damage through both pathology and biochemistry studies. Additionally, we briefly present the results of a study conducted in our clinic on 849 patients admitted for COVID-19 treatment, of which 31 patients had pre-existing chronic liver disease and 388 patients had values above the normal limit for alanine aminotransferase, aspartate aminotransferase, and total bilirubin. It was observed that patients with abnormal liver tests were significantly statistically older, had more comorbidities and had a higher percentage of unfavourable evolution (death or transfer to intensive care). The conclusion of this paper is that the main causes of liver damage are direct viral aggression, coagulation dysfunction and endothelial damage, and patients with impaired liver function develop more severe forms of COVID-19 which requires special care by a multidisciplinary team that includes a hepatologist.

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Therapeutic potential of pyrrole and pyrrolidine analogs: an update

Basha¹,

Basavarajaiah²,

Shyamsunder³

2022

Mol Divers

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The chemistry of nitrogen-containing heterocyclic compound pyrrole and pyrrolidine has been a versatile field of study for a long time for its diverse biological and medicinal importance . Biomolecules such as chlorophyll, hemoglobin, myoglobin, and cytochrome are naturally occurring metal complexes of pyrrole. These metal complexes play a vital role in a living system like photosynthesis, oxygen carrier, as well storage, and redox cycling reactions. Apart from this, many medicinal drugs are derived from either pyrrole, pyrrolidine, or by its fused analogs. This review mainly focuses on the therapeutic potential of pyrrole, pyrrolidine, and its fused analogs, more specifically anticancer, anti-inflammatory, antiviral, and antituberculosis. Further, this review summarizes more recent reports on the pyrrole, pyrrolidine analogs, and their biological potential. Graphical Abstract

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Effectiveness of 8- and 12-Week Treatment with Ombitasvir/ Paritaprevir/Ritonavir and Dasabuvir in Treatment-Naïve HCV Patients in a Real-Life Setting in Romania: the AMETHYST Study

Cited by 4 publications

References 22 publications

N-Heterocycles as Promising Antiviral Agents: A Comprehensive Overview

N-Heterocycles as Promising Antiviral Agents: A Comprehensive Overview

COVID-19 impact on the liver

Therapeutic potential of pyrrole and pyrrolidine analogs: an update

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