2014
DOI: 10.1111/jdv.12500
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Effective treatment of scrotal lichen simplex chronicus with 0.1% tacrolimus ointment: an observational study

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Cited by 6 publications
(3 citation statements)
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“…Our patient presented with the typical clinical features of MP and a supportive history of recent bariatric surgery. The use of topical tacrolimus has not been previously reported in MP, but it has been reported in another neuropathic itch, notalgia paresthetica, and its antipruritic effect has been reported in atopic dermatitis, as well as in a few chronic pruritic conditions . The exact mechanism of action of topical tacrolimus in MP is not known, but it is believed to have a capsaicin‐like effect and may mediate its antipruritic effect through activation of the transient receptor potential vanilloid 1 (TRPV1) located on peripheral nerve fibers .…”
Section: Discussionmentioning
confidence: 99%
“…Our patient presented with the typical clinical features of MP and a supportive history of recent bariatric surgery. The use of topical tacrolimus has not been previously reported in MP, but it has been reported in another neuropathic itch, notalgia paresthetica, and its antipruritic effect has been reported in atopic dermatitis, as well as in a few chronic pruritic conditions . The exact mechanism of action of topical tacrolimus in MP is not known, but it is believed to have a capsaicin‐like effect and may mediate its antipruritic effect through activation of the transient receptor potential vanilloid 1 (TRPV1) located on peripheral nerve fibers .…”
Section: Discussionmentioning
confidence: 99%
“…The use of topical tacrolimus has not been previously reported in MP, but it has been reported in another neuropathic itch, notalgia paresthetica, 2 and its antipruritic effect has been reported in atopic dermatitis, 3 as well as in a few chronic pruritic conditions. 4,5 The exact mechanism of action of topical tacrolimus in MP is not known, but it is believed to have a capsaicin-like effect and may mediate its antipruritic effect through activation of the transient receptor potential vanilloid 1 (TRPV1) located on peripheral nerve fibers. 6,7 After activation of this ion channel, nerve fibers are depolarized, resulting in the transmission of pain signals.…”
Section: Discussionmentioning
confidence: 99%
“…Bu hastalar hastalığın kronik seyri nedeniyle uzun süreli topikal kortikosteroid tedavileri almak zorunda kalmaktadırlar. Son yıllarda liken simpleks kronikusun topikal tedavisinde takrolimus gibi yeni ajanlar da dahil olmuştur [9]. Yine fototerapi uygulamaları da liken simpleks kronikus tedavisinde kullanılabilecek alternatifler arasında yer alabilir [10].…”
Section: Discussionunclassified