Effective Treatment of Heavy Menstrual Bleeding With Estradiol Valerate and Dienogest

Jensen, Jeffrey T.; Parke, Susanne; Mellinger, Uwe; Machlitt, A.; Fraser, Ian S.

doi:10.1097/aog.0b013e3182118ac3

Cited by 109 publications

(65 citation statements)

References 23 publications

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“…Blood loss has been reported to be reduced by almost 90% in users of E2/dienogest Jensen et al 2011] and the use has a consistent positive impact on work productivity and activities of daily living in women with HMB [Wasiak et al 2012]. COC use also has a significant impact on the occurrence and severity of dysmenorrhea [Milsom et al 1990;Harada et al 2008].…”

Section: Menstrual Blood Lossmentioning

confidence: 99%

Combined hormonal contraceptives: prescribing patterns, compliance, and benefits versus risks

Brynhildsen

2014

Therapeutic Advances in Drug Safety

122

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Combined hormonal contraceptives [combined oral contraceptives (COCs)] have been available for over 50 years and the impact of this invention may not be overestimated. Today over 100 million women are current users and in Western Europe and the United States approximately 80% of women of fertile ages can be considered as ever-users. Over the years several drawbacks have been identified and media alarms on risks are frequently presented, resulting in suboptimal compliance and low compliance and continuation rates. Poor compliance and discontinuation is a big problem and is not generally identified by prescribers. During ideal use COCs offer very good protection against unwanted pregnancies, however there is a big problem with compliance and continuation and thus the 'real-life' efficacy is much lower. Reasons for poor compliance include side effects and fear of side effects and it is crucial that the prescriber gives the individual woman thorough and balanced information on the benefits and risks. Most well known is the increased risk of venous thromboembolism, but also an elevated risk of arterial thrombosis and several types of cancer has been reported. The risk estimates are low but according to the large number of users a substantial number of extra cases will occur. However, use of COCs also offers several additional health benefits with significant impact on morbidity and quality of life. COC use is associated with a substantial decrease in the risk of ovarian cancer, endometrial cancer and colorectal cancer. Moreover, COCs are a major option of treatment for women suffering from heavy menstrual bleeding and dysmenorrhea as well as hirsutism and acne vulgaris. The net effect of the additional health effects of COC-use may very well be positive, i.e. a slight increase in life expectancy.

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Section: Menstrual Blood Lossmentioning

confidence: 99%

Combined hormonal contraceptives: prescribing patterns, compliance, and benefits versus risks

Brynhildsen

2014

Therapeutic Advances in Drug Safety

122

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“…45 Randomized trials involving women with heavy menstrual bleeding have shown the efficacy of an oral contraceptive containing estradiol valerate and dienogest, and of a combined contraceptive vaginal ring in treating this condition. 46,47 …”

Section: Heavy Menstrual Bleedingmentioning

confidence: 99%

Contraception in women over 40 years of age

Allen

Cwiak

Kaunitz

2013

CMAJ

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“…Recently, two randomized trials of an OC containing estradiol valerate and dienogest provided solid proof of the efficacy of COCs for this treatment. 52,53 The reduction of blood loss in the study group varied from 60% to 70% compared with the placebo group. 52,53 Less-frequent menses or amenorrhea can be achieved with extended estrogen-progestogen COC regimens; however, there are no studies to prove that this mode of administration is superior to the cyclic use of COCs for treating heavy menstrual bleeding.…”

Section: Noncontraceptive Therapeutic Indications For Cocs Heavy Mensmentioning

confidence: 99%

Non-contraceptive benefits of oral contraceptives

Dhont¹

2011

OAJC

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Abstract:The health benefits of the oral contraceptive (OC) pill are numerous and outweigh the risks of OC use. There are unintended but useful preventive side effects and potential therapeutic uses of OCs apart from contraception itself. Unequivocal evidence for the protective influence of combined OCs against ovarian and endometrial cancers, and colon cancer to a lesser extent, has been found. The pill also reduces the incidence of benign breast disease, functional ovarian cysts, pelvic inflammatory disease requiring hospitalization, ectopic pregnancy, and irondeficiency anemia. The pill can be used for the treatment of several gynecologic disorders such as dysmenorrhea, irregular or excessive bleeding, acne, hirsutism, and endometriosis-associated pain, whether prescribed solely to treat these symptoms or prescribed to treat them in addition to providing contraception. These health benefits are often underestimated, as they get too little attention from the mass media.

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Effective Treatment of Heavy Menstrual Bleeding With Estradiol Valerate and Dienogest

Abstract: I.

Cited by 109 publications

References 23 publications

Combined hormonal contraceptives: prescribing patterns, compliance, and benefits versus risks

Combined hormonal contraceptives: prescribing patterns, compliance, and benefits versus risks

Contraception in women over 40 years of age

Non-contraceptive benefits of oral contraceptives

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