Effective treatment for sensitive skin: 4‐t‐butylcyclohexanol and licochalcone A

Sulzberger, Marion B.; Worthmann, Anne-Christin; Holtzmann, Ursula; Buck, B.; Jung, Kwon; Schoelermann, Andrea M.; Rippke, Frank; Stäb, Franz; Wenck, Horst; Neufang, Gitta; Grönniger, Elke

doi:10.1111/jdv.13529

Cited by 44 publications

(41 citation statements)

References 32 publications

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“…There is limited published data describing the effect of topical serums on sensitive skin. Clearly sunscreen use will reduce skin erythema but many plant extracts and oils/acids as well as beta glucans, sodium hyaluronate, glycerine, 4‐t‐butylcyclohexanol, tranexamic acid, oxyresveratrol, glutathione disulphide, licochalcone A and niacinamide are also known to reduce skin redness .…”

Section: Discussionmentioning

confidence: 99%

Clinical and in vitro evaluation of new anti‐redness cosmetic products in subjects with winter xerosis and sensitive skin

Nisbet

Targett

Rawlings³

et al. 2019

Intern J of Cosmetic Sci

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OBJECTIVE: To demonstrate the in vitro activities of panthenol, palmitoylethanolamide (PEA), and niacinamide (NAM) and determine the biophysical properties, clinical safety, tolerability together with efficacy of two developmental anti-redness (AR) formulations containing these ingredients, in alleviating facial redness associated with winter xerosis in healthy volunteers with sensitive skin. METHODS: The anti-inflammatory and skin protective properties of panthenol, PEA and NAM were evaluated in vitro. The physical properties of the AR formulations were analysed using measurement of water vapour transport rate (WVTR) and infrared spectroscopy. Clinical studies were performed between the months of December and April (2014-2015) with efficacy assessed during the winter. Facial redness, irritation, sensitization potential, photo-irritation, and photo-sensitization were evaluated. Self-assessed adverse reactions were reported in diaries of use. RESULTS: Panthenol and PEA reduced prostaglandin E 2 , interleukin-6, and thymic stromal lymphopoietin levels in vitro, while NAM induced nicotinamide adenine dinucleotide (NAD) levels and the keratinocyte differentiation markers: filaggrin (2-fold increase, P < 0.001), loricrin (2-fold increase, P < 0.05), involucrin (2 fold increase, P < 0.001) & peroxisomal proliferator activated receptoralpha (1.5 fold increase, P < 0.05). The two AR products exhibited low WVTR vs. no treatment (P < 0.001) and displayed an ordered lipid structure. The day cream formulation protected against ultraviolet B radiation in vitro. A total of 382 participants were included in clinical studies which showed the AR formulations significantly improved facial redness associated with winter xerosis (Day 29 mean change from baseline: AR day cream 0.77 (P < 0.001); AR serum 0.67 (P < 0.001)). No irritation, sensitization, photo-irritation, photo-sensitization or product-related adverse reactions were observed or reported in the clinical studies. CONCLUSION: The new products significantly improved skin redness associated with winter xerosis in participants with selfperceived sensitive skin. Both products were well tolerated with a suitable safety profile for topical use in subjects with sensitive skin. Evaluationof anti-redness face cream and serum S. J. Nisbet et al. 536 Evaluation of anti-redness face cream and serum S. J. Nisbet et al. 538 Evaluation of anti-redness face cream and serum S. J. Nisbet et al. Evaluation of anti-redness face cream and serum S. J. Nisbet et al. 540 Evaluation of anti-redness face cream and serum S. J. Nisbet et al. 542 Evaluation of anti-redness face cream and serum S. J. Nisbet et al. Evaluation of anti-redness face cream and serum S. J. Nisbet et al. P value <0.001 <0.001 CI, confidence interval; ITT, intention-to-treat; SD, standard deviation. 544Evaluation of anti-redness face cream and serum S. J. Nisbet et al.

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Section: Discussionmentioning

confidence: 99%

Clinical and in vitro evaluation of new anti‐redness cosmetic products in subjects with winter xerosis and sensitive skin

Nisbet

Targett

Rawlings³

et al. 2019

Intern J of Cosmetic Sci

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“…Liberal applications of plain emollients are also sensible therapeutic measures to reduce TEWL and increase epidermal thickness. Other treatments documented in the literatures like TRPV 1 antagonist 4-tbutylcyclohexanol and licochalcone, low level energy device like laser and intense pulse light, cosmetic products and ingestion of probiotics may not be applicable due to the inaccessibility and inapplicability of these therapeutic measures in our specific case [21][22][23][24]. The DLQI on the last clinic visit on 10 April 2019 showed a patient self-reported improvement of health, emotion, anxiety and happiness status.…”

Section: Discussionmentioning

confidence: 99%

An Unusual Presentation of Sensitive Skin Syndrome over the Lips of a Female Chinese Patient after Dental Procedure Managed and Improved with 0.03% and 0.1% Topical Tacrolimus Ointment Application as Assessed by the SS-10 Questionnaire

Chan¹

2019

J Clin Exp Dermatol Res

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Sensitive skin syndrome (SSS) is a prevalent skin condition reported globally in most ethnic groups which may occur in any skin location. The cause and pathogenesis of SSS is still unresolved and controversial. Albeit the head and neck region including the face and scalp are reported as the commonest sites of SSS, the lips as the only region of the face affected has been rarely reported in the literature. We report a case of a 30 years old Chinese women with a positive family history of nasopharyngeal carcinoma who reported to have significant neurological, nociceptive and pruritoceptive symptoms solely over the lips lasting for more than one year complicated by psychological and sleep disturbances after dental procedure. She was followed up and monitored by the validated 10-items Sensitive Skin Scale questionnaire (SS-10) in the clinic setting, treated and managed by topical tacrolimus ointment, emollients, counselling, education and psychological supports.

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“…Through disentangling the relationship between the pathogenesis of sensitive skin and TRP channels and TRPV1 antagonist, it indicates that trans-4-tert-butylcyclohexanol and licochalcone are effective in treating sensitive skin [36]. Pimecrolimus down regulates TRP receptors, decrease TWEL and may increase epidermal thickness [37,38].…”

Section: Managementmentioning

confidence: 99%

Sensitive Skin Syndromes and Transient Receptors Potential (TRP) Channels in Sensitive Skin

2018

IJCED

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Sensitive skin is a prevalent skin condition affecting both female and male worldwide without the presence of perceivable signs. The associations between sensitive skin and pre-existing skin diseases of atopy and dermatitis, dry skin, rosacea and food hypersensitivity in the gut with cognitive complications are referred to as Sensitive Skin Syndrome (SSS), making this disease more complex. Neurogenic and non-neurogenic inflammation, epidermal barrier defects, TRP ions channels interplay with the central nervous system combining with subsequent perceptive cognitive motor behaviour appears to be the main pathogenetic mechanism. Further research and studies of this intriguing condition may further enlighten us on how different systems of the body: skin, nervous system, cognition and gut integrate functionally and pathologically as a whole. and France in studies employing different methodologies. Reactive skin, over reactive skin, intolerant skin and irritable skin were used

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Effective treatment for sensitive skin: 4‐t‐butylcyclohexanol and licochalcone A

Cited by 44 publications

References 32 publications

Clinical and in vitro evaluation of new anti‐redness cosmetic products in subjects with winter xerosis and sensitive skin

Clinical and in vitro evaluation of new anti‐redness cosmetic products in subjects with winter xerosis and sensitive skin

An Unusual Presentation of Sensitive Skin Syndrome over the Lips of a Female Chinese Patient after Dental Procedure Managed and Improved with 0.03% and 0.1% Topical Tacrolimus Ointment Application as Assessed by the SS-10 Questionnaire

Sensitive Skin Syndromes and Transient Receptors Potential (TRP) Channels in Sensitive Skin

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