Effective Protection Against Influenza After Vaccination With Subunit Vaccine

Cost-Benefit Analysis of a Strategy to Vaccinate Healthy Working Adults Against Influenza

“…In adults annual laboratory-confirmed influenza illness rates may be as low as 5% as reported for the placebo groups in 2 recently published clinical trials 14,15 assessing the effectiveness of neuraminidase inhibitors for the prevention of influenza. In another controlled trial, 16 however, the laboratory-confirmed illness rate among unvaccinated participants was 13%. The 8-year average influenza illness rates in 1 longitudinal study 17 spanning the years from 1976 through 1984 ranged from 19.7% for persons aged 18 to 24 years to 14.8% for persons 35 years or older.…”

“…During years with a good match between circulating viruses and the corresponding vaccine strains, vaccine efficacy for reducing laboratory-confirmed influenza illness has generally been 70% to 90% (Table 5). 16,[32][33][34][35] For this study, the base-case vaccine efficacy rate for years with a good match was 75% (range, 60%-90%). During years with a poor match, vaccine efficacy in several previous studies [32][33][34] has been observed to be 30% to 60%.…”

Effectiveness of Influenza Vaccine in Health Care Professionals

“…influenza among hospitalized patients, causing a variety of adverse effects from increased hospital costs to death, 18,19 there are conflicting data on whether influenza vaccine decreases the rate of influenza infection or sick leave among health care professionals. [20][21][22][23][24][25] However, compliance with the Advisory Committee on Immunization Practices recommendations by physicians and nurses has been poor, with rates of influenza vaccination among health care professionals reported to range from 16% to 51%. 19,26,27 We undertook a prospective randomized, double-blind, controlled study to determine the benefits of influenza vaccination in young, healthy health care professionals.…”