Effective on-line purification for cationic compounds in rat bile using a column-switching LC technique

Sensitive determination of aspirin and its metabolites in plasma by LC–UV using on-line solid-phase extraction with methylcellulose-immobilized anion-exchange restricted access media

“…We have also reported the use of MC-strong cation-exchanger (MC-SCX) for the analysis of cationic drugs and metabolites in plasma and in bile [19][20][21]. These columns allow for an automated analysis of small analytes in plasma that is rapid, simple, and accurate.…”

Restricted access media as a streamlined approach toward on‐line sample preparation: Recent advancements and applications

“…These analytes can then be eluted from the trap column into an analytical column for fast and efficient analysis. The different combinations of inner and outer stationary phase chemistries that have been introduced over the years are many [13,[40][41][42][43][44]. Each type of ISP RAM offers unique advantages that are useful in different applications.…”

“…The different combinations of inner and outer stationary phase chemistries that have been introduced over the years are many . Each type of ISP RAM offers unique advantages that are useful in different applications.…”

Effective on-line extraction of drugs from plasma using a restricted-access media column in column-switching HPLC equipped with a dilution system: Application to the simultaneous determination of ER-118585 and its metabolites in canine plasma

“…Today's commercially available RAM columns are sufficiently stable to allow for their routine use in the pharmaceutical industry [3,4], where they help to automate the on-line preparation of drug samples in biological fluids [2,5]. An additional advantage of this methodology is that it allows for a reduction of the matrix effect in drug analysis in plasma using HPLC-electrospray ionization-mass spectrometry (ESI-MS) [6].…”