Effective Entrapment of Protein into Polylactide Microcapsule by Solvent Evaporation of W/O/W Emulsion.

弘一郎, 塩盛; 恵宣, 河野; 史朗, 清山; 秀和, 吉澤; 芳三, 上村; 泰雄, 幡手

doi:10.1252/kakoronbunshu.26.50

Cited by 8 publications

(1 citation statement)

References 9 publications

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“…Recently, it is strongly demanded to develop the microencapsulation method using the low loaded materials to environment. For example, organic solvents such as dichloromethane, toluene, and benzene as the solvent for polystyrene as the most popular shell material have been used in the drying‐in‐liquid method 1–3. However, these solvents are strongly restricted for use at present.…”

Section: Introductionmentioning

confidence: 99%

Effect of viscosity of shell solution on the content of solid powder as core material in microencapsulation by the drying‐in‐liquid method

Yokoyama

Liu

Taguchi

2008

J of Applied Polymer Sci

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Solid powder generating minus ion was microencapsulated by polystyrene with the drying-in-liquid method. In the microencapsulation, (R)-(þ) limonene as the solvent for polystyrene and ethylene glycol as the continuous phase were adopted instead of the conventional organic solvent such as dichloromethane, benzene and toluene, and water, respectively. It was mainly investigated whether the solvents adopted here could be applied to the drying-in-liquid method or not and how the viscosity of the shell solution and the oil soluble surfactant affected the content of core material. The oil soluble surfactant made hydrophilic solid powder more hydrophobic and resulted in an increase of the content. Microcapsules containing solid powder could be prepared with the drying-in-liquid method using (R)-(þ) limonene and ethylene glycol. An increase in the viscosity of the shell solution repressed the movement of solid powder particles in a droplet of the shell solution during the microencapsulation process and resulted in the higher content.

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Section: Introductionmentioning

confidence: 99%

Effect of viscosity of shell solution on the content of solid powder as core material in microencapsulation by the drying‐in‐liquid method

Yokoyama

Liu

Taguchi

2008

J of Applied Polymer Sci

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Biodegradable poly(lactic acid) microspheres containing total alkaloids of Caulis sinomenii

2011

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The fabrication of biodegradable poly(lactic acid) (PLA) microspheres containing total alkaloids of Caulis sinomenii was investigated. The formation, diameter, morphology and properties of the microspheres were characterized using Fourier transform infrared spectroscopy (FT-IR), laser particle size analyser and scanning electron microscopy (SEM), etc. In vitro releasing behaviour was also investigated using UV-Vis spectrometer. As a result, the drug-loaded microspheres with a narrower distributive, rounder and smoother surface were prepared. Drug-releasing behaviour from microspheres was affected by the concentration of emulsifier and the stirring rate. The results demonstrated that a medicated system, which can be potentially applied within a drug delivery system, was designed. This system acts in a systematic manner for the treatment of rheumatoid arthritis.

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Factors affecting the loading efficiency of water-soluble drugs in PLGA microspheres

Ito

Fujimori

Makino

2008

Colloids and Surfaces B: Biointerfaces

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Effective Entrapment of Protein into Polylactide Microcapsule by Solvent Evaporation of W/O/W Emulsion.

Cited by 8 publications

References 9 publications

Effect of viscosity of shell solution on the content of solid powder as core material in microencapsulation by the drying‐in‐liquid method

Effect of viscosity of shell solution on the content of solid powder as core material in microencapsulation by the drying‐in‐liquid method

Biodegradable poly(lactic acid) microspheres containing total alkaloids of Caulis sinomenii

Factors affecting the loading efficiency of water-soluble drugs in PLGA microspheres

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