Biodegradable poly(lactic acid) microspheres containing total alkaloids of Caulis sinomenii

Abstract

The fabrication of biodegradable poly(lactic acid) (PLA) microspheres containing total alkaloids of Caulis sinomenii was investigated. The formation, diameter, morphology and properties of the microspheres were characterized using Fourier transform infrared spectroscopy (FT-IR), laser particle size analyser and scanning electron microscopy (SEM), etc. In vitro releasing behaviour was also investigated using UV-Vis spectrometer. As a result, the drug-loaded microspheres with a narrower distributive, rounder and smoother surface were prepared. Drug-releasing behaviour from microspheres was affected by the concentration of emulsifier and the stirring rate. The results demonstrated that a medicated system, which can be potentially applied within a drug delivery system, was designed. This system acts in a systematic manner for the treatment of rheumatoid arthritis.

Sinomenine-loaded microcapsules fabricated by phase reversion emulsification-drying in liquid method: An evaluation of process parameters, characterization, and released properties

“…When the emulsifier concentration was 5%, the EE and DL were satisfied and reached the optimum value (89.2% and 8.9%). In previous studies, 47,48 the EE of PLA microspheres was about 80% and DL was about 8% under the optimal conditions. Compare with typical emulsion methods, the phase inversion emulsion method can improve the EE and DL of drug-loaded microcapsules and narrow the particle size range.…”

“…Comparing the release profiles of the microcapsules prepared with 7% and 6% emulsifier concentration, it was observed that the microcapsules of 5% emulsifier had the slowest SM release rate, and 74% of the total SM was release at 96 h. However, the SM release rate of the other two groups increased to 87% and 83% at 96 h. The reason for this phenomenon was assumed to be that the diameter of microcapsules significantly affected the release of SM. 48 For the microcapsules, with decreasing the diameter, the surface area exhibited an increasing so the release rate became more pronounced. 52 In Figure 4(b), it could be observed that the release profile of three groups of microcapsules was similar with Figure 4(a) during the whole release process.…”

Fast and Environmentally Friendly Microfluidic Technique for the Fabrication of Polymer Microspheres

“…Therefore, the application of polymer inclusion PVDF-HFP-based microspheres for separation and preconcentration of analytes in chemical analysis is expected to be of considerable interest. PLA is of interest for the fabrication of microspheres for drug delivery, ,, while PS microspheres have important biological applications such as blood flow measurement . Optical images of the microspheres obtained using different concentrations of these polymers are shown in Figure .…”