Effect of rapid expansion of subcritical solutions processing conditions on loading capacity of tetrahydrocurcumin encapsulated in poly(l-lactide) particles

Songtipya, Ladawan; Thies, Mark C.; Sane, Amporn

doi:10.1016/j.supflu.2016.03.020

Cited by 10 publications

(1 citation statement)

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“…This supercritical fluid technology creates stable, well-dispersed and uniform nanosuspensions at low temperature and uses less to none of the organic solvents that is plus for the environment (Kumari et al, 2010;Kakran et al, 2012;Hatahet et al, 2016). The advantages of the RESOLV process include producing smaller nanoparticles with narrow size distributions, nanoparticles that are readily dispersed in a liquid medium containing a small amount of dispersing agent and a nanosuspension is directly obtained from the process (Türk, 2009;Songtipya et al, 2016). However, there are still some limitations to the RESOLV process, such as the active compound needs to be dissolved in supercritical carbon dioxide, otherwise the addition of a suitable organic solvent is required to improve the solvent power of supercritical carbon dioxide.…”

Section: Introductionmentioning

confidence: 99%

Novel, bioactive film based on methylcellulose incorporated with quercetin-loaded nanoparticles: Bifunctional antioxidant and ultraviolet- shielding properties

2022

ANRES

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Article InfoA novel, bifunctional nanocomposite methylcellulose (MC) film was developed with antioxidant and ultraviolet (UV)-shielding properties. Quercetin (QC) nanoparticles (NPs) with an average size of approximately 60 nm were generated using a rapid expansion process. Quantification of the total phenolic content (TPC) was performed, followed by three assays-2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, 2,2'-azinobis (3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical cation decolorization and ferric reducing antioxidant power (FRAP)-to investigate the antioxidant effectiveness of the QC-NPs. The QC-NPs had a TPC value of 1,619.59 μg gallic acid equivalents/ mg and high antioxidant activities. The QC-impregnated MC films with all treatments (impregnated with ethanol (QC-EtOH)-, nanoparticles (QC-NPs) or water (QC-H 2 O-MC) with concentrations of 0.1-0.5% w/w) were fabricated using the solution casting technique and characterized. The addition of QC into the MC films was substantiated using Fourier transform infrared spectroscopy. Impregnation of the QC-NPs into the MC film demonstrated that the QC-NPs augmented the antioxidant activities of QC and substantially improved the UV-shielding property of the MC film.

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