Loading of Drugs in Biodegradable Polymers Using Supercritical Fluid Technology

Díaz, Janet de los Angeles Chinellato; Bordín, Santiago Fernandez; Mattea, Facundo; Romero, Marcelo Ricardo

doi:10.1002/9781394167258.ch7

Cited by 1 publication

(1 citation statement)

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“…Giray S. and Ulker Z. et al showed that this method of drug delivery reduces the side effects and increases the bioavailability of the drug, especially for poorly soluble drugs [ 11 , 12 ]. One of these compounds is mefenamic acid (MFA) which, due to several restrictions, is not recommended for use as a non-steroidal anti-inflammatory drug [ 13 , 14 , 15 ]. Therefore, Tan F. et al searched for ways to improve the form of mefenamic acid in order to repurpose it as a drug and to give developed or forgotten drugs, such as mefenamic acid, a chance to enter a new therapy field [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Conformational Equilibrium of Mefenamic Acid Released from Silica Aerogels via NMR Analysis

Khodov

Sobornova

Mulloyarova

et al. 2023

IJMS

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This study examines the influence of mefenamic acid on the physical and chemical properties of silica aerogels, as well as its effect on the sorption characteristics of the composite material. Solid state magic angle spinning nuclear magnetic resonance (MAS NMR) and high-pressure 13C NMR kinetic studies were conducted to identify the presence of mefenamic acid and measure the kinetic rates of CO2 sorption. Additionally, a high-pressure T1–T2 relaxation-relaxation correlation spectroscopy (RRCOSY) study was conducted to estimate the relative amount of mefenamic acid in the aerogel’s pores, and a high-pressure nuclear Overhauser effect spectoscopy (NOESY) study was conducted to investigate the conformational preference of mefenamic acid released from the aerogel. The results indicate that mefenamic acid is affected by the chemical environment of the aerogel, altering the ratio of mefenamic acid conformers from 75% to 25% in its absence to 22% to 78% in the presence of aerogel.

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