Effective DNA binding and cleaving tendencies of malonic acid coupled transition metal complexes

Pravin, Narayanaperumal; Utthra, Ponnukalai Ponya; Kumaravel, Ganesan; Raman, Natarajan

doi:10.1016/j.molstruc.2016.06.034

Cited by 26 publications

(18 citation statements)

References 57 publications

(29 reference statements)

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“…Interestingly, the complexes with planar co‐ligands comparatively showed good binding affinity towards the DNA compared with the previously reported benzimidazole‐based complexes. This emphasizes the fact that the intercalative nature and binding affinity might be due to the aromatic planar ligands with good conjugation . The absorption spectrum for complex 5 is given in Figure .…”

Section: Resultsmentioning

confidence: 90%

DNA fastening and scission actions of Cu(II), Co(II), Ni(II) and Zn(II) complexes: synthesis, spectral characterization and cytotoxic study

Kumaravel¹,

Utthra²,

Raman³

2017

Applied Organom Chemis

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A heterocyclic compound, 2‐(aminomethyl)benzimidazole dihydrohydrochloride, was treated with nitrobenzaldehyde to form a Schiff base that was made to react with divalent metals. A co‐ligand, either 1,10‐phenanthroline or 2,2′‐bipyridine, was added to this mixture to obtain metal chelators of type [ML(co‐L)2]Cl2. They were in 1:1:2 stoichiometry ratio, which was characterized by various spectroscopic techniques that suggested an octahedral geometry around the central metal ions. These complexes were investigated for their binding affinities with calf thymus (CT) DNA, using various techniques, such as UV–Vis, viscosity, cyclic voltammetry (CV), etc. The binding interaction studies revealed intercalation as the possible binding mode of the complexes with the CT DNA. In addition, these complexes were screened for their antimicrobial potential and DNA denaturing tendencies using gel electrophoretic assay. The antimicrobial screening investigation showed that the complexes behaved as better antimicrobial agents than the ligand, especially, complex 5 shows exceptional activity even in the electrophoretic assay along with the antimicrobial efficacy. Moreover, complex 5 was able to denature the plasmid DNA better than the other compounds. All the compounds were screened for cytotoxic efficacy, and the IC50 values suggest that the compounds possess cytotoxic activity to some extent that is almost the same as the activity of cisplatin.

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Section: Resultsmentioning

confidence: 90%

DNA fastening and scission actions of Cu(II), Co(II), Ni(II) and Zn(II) complexes: synthesis, spectral characterization and cytotoxic study

Kumaravel¹,

Utthra²,

Raman³

2017

Applied Organom Chemis

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“…In the absence of CT‐DNA, Pc4 and Pc5 had a couple of waves with the cathodic (EPc) and anodic peak potential (EPa) being −0.55 V (EPc) and −0.71, and 0.61 V (EPa) for Pc4 in Figure (red line), and −0.34 V, 0.69 V (EPc) and −0.5, 0.1 and 0.9 V (Epa) for Pc5 in Figure (red Line)), respectively. In the presence of CT‐DNA, after the addition of CT‐DNA to Pc4 andd Pc5 , the cyclic voltammetric peak currents apparently decreased, which is an indicator of the interaction between the compounds and CT‐DNA . Decrease in the voltammetric currents in the presence of CT‐DNA may be a sign of low diffusion of Pc4 and Pc5 that were binding to CT‐DNA.…”

Section: Resultsmentioning

confidence: 99%

Investigation of DNA‐Binding Activities of Zinc(II) and Cobalt(II) Phthalocyanine Compounds with 3,4,5‐Trimethoxybenzyloxy Substituents

Arslantaş

Ağırtaş

2017

ChemistrySelect

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In this study, DNA‐binding activities of previously synthesized tetrakis(3,4,5‐trimethoxybenzyloxy)‐substituted Zn(II) and Co(II) phthalocyanines (Pc4 and Pc5) have been chosen for the study. The interaction of synthesized tetrakis(3,4,5‐trimethoxybenzyloxy)‐substituted Zn(II) and Co(II) phthalocyanine compounds with CT‐DNA was investigated by using UV/Vis titrimetric method, fluorescence spectroscopy, cyclic voltammetry, thermal denaturation profile, gel electrophoresis and viscosty measurement in a Tris‐HCI buffer at pH 7.0. The results indicated that tetrakis(3,4,5‐trimethoxybenzyloxy)‐substituted Zn(II) and Co(II) phthalocyanines (Pc4 and Pc5) can interact with CT‐DNA via intercalation binding mode.

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“…The intercalation binding of PcCo to DNA molecule can enhance to melting temperature of DNA molecule because of strength of binding. In the case of non-intercalative binding of PcCo to DNA molecule, the melting point temperature of DNA can drop [35,36]. In this study, in the absence and presence of PcCo, thermal denaturation experiments were performed to specify binding activities between PcCo and calf thymus-DNA as indicated in Fig.…”

Section: Melting Point Temperature Studiesmentioning

confidence: 99%

“…These results explicitly show that intensities of DNA bands were dropped after interaction of PcCo with DNA when it is compared to the band of calf thymus-DNA control (C). The decreasing in the intensity of DNA bands after interaction of PcCo with calf thymus-DNA is considered to be owing to deformation of DNA double-stranded [17,23,35,36,37].…”

Section: Gel Electrophoresis Studiesmentioning

confidence: 99%

2, 10, 16, 24-Tetrakis 4- (2-fenoksi-l, 3-diokso-2,3-dihidro-lH-inden-2-iloksi) ftalonitril içeren kobalt (II) bileşiğinin DNA bağlanmasının spektroskopik yöntemler ile araştırılması

Arslantaş

Ağırtaş

2017

Academic Platform-Journal of Engineering and Science

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In this study, binding activities of the previously synthesized cobalt (II) compound (PcCo) with calf thymus-DNA containing 2, 10, 16, 24-tetrakis 4-(2-phenoxy-1, 3-dioxo-2, 3-dihydro-1H-inden-2-yloxy) phthalonitrile were investigated to determine binding activities by using UV-Vis absorption, fluorescence titration methods. Absorption titration spectra of PcCo in DMF give peaks at about 670 nm for Q-band absorption and about 340 nm for B-band absorption in the absence of calf thymus-DNA. Emission intensities of PcCo in presence of calf thymus-DNA, PcCo gives emission at about 545 nm. Thermal denaturation profile study was systematically studied by UV/Vis spectroscopic technique and melting point temperature was found around 7.87 o C for Co (II) phthalocyanine compound. The reduction oxidation behavior of PcCo with calf thymus-DNA was investigated using cyclic voltammetry (CV). Cathodic peak potential and anodic peak potential for PcCo were recorded to be 0.84, -0.36 V for EPc and 0.88 V, 0.15 V, and -0.69 V EPa. The cyclic voltammetric results show one halfreversible reduction oxidation wave. The shift in Epc and Epa potentials indicates that PcCo shows strong interaction with calf thymus-DNA. Further to understand binding activities of PcCo with calf thymus-DNA was studied by using electrophoresis technique. Electrophoresis findings showed that there is decrease in the intensity of CT-DNA bands. All the findings show that PcCo interacts strongly with DNA molecule via an intercaltion binding.

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Effective DNA binding and cleaving tendencies of malonic acid coupled transition metal complexes

Cited by 26 publications

References 57 publications

DNA fastening and scission actions of Cu(II), Co(II), Ni(II) and Zn(II) complexes: synthesis, spectral characterization and cytotoxic study

DNA fastening and scission actions of Cu(II), Co(II), Ni(II) and Zn(II) complexes: synthesis, spectral characterization and cytotoxic study

Investigation of DNA‐Binding Activities of Zinc(II) and Cobalt(II) Phthalocyanine Compounds with 3,4,5‐Trimethoxybenzyloxy Substituents

2, 10, 16, 24-Tetrakis 4- (2-fenoksi-l, 3-diokso-2,3-dihidro-lH-inden-2-iloksi) ftalonitril içeren kobalt (II) bileşiğinin DNA bağlanmasının spektroskopik yöntemler ile araştırılması

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