Effective Delivery of Stem Cells Using an Extracellular Matrix Patch Results in Increased Cell Survival and Proliferation and Reduced Scarring in Skin Wound Healing

Lam, Mai T.; Meyer, Nathaniel P.; Wu, Joseph C.; Longaker, Michael T.

doi:10.1089/ten.tea.2012.0480

Cited by 78 publications

(73 citation statements)

References 19 publications

(21 reference statements)

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“…Therefore, scaffold-loaded stem cells may increase stem cell efficacy. 113 MSC persistent engraftment might be a limitation of MSC therapy when treating wounds. In nonwound injury models, engraftment appears to be affected by the delivery protocol of MSCs into the site of the wound.…”

Section: Strategies For Delivering Mscsmentioning

confidence: 99%

Mesenchymal Stem Cells in Chronic Wounds: The Spectrum from Basic to Advanced Therapy

Otero-Viñas

Falanga

2016

Advances in Wound Care

121

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Section: Strategies For Delivering Mscsmentioning

confidence: 99%

Mesenchymal Stem Cells in Chronic Wounds: The Spectrum from Basic to Advanced Therapy

Otero-Viñas

Falanga

2016

Advances in Wound Care

121

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“…Another important factor involved in wound healing is stem cells, whose popularity has recently increased. With stem cell treatment, accelerated wound healing and reductions in scar formation have been observed by many researchers 17,18 . We compared the scar types in patients operated on for different reasons (but with the same type of incisions) There have been no studies in the literature observing the relationship between the presence of striae and scar formation.…”

Section: Discussionmentioning

confidence: 99%

Factors affecting the development of scar formation in abdominal surgery performed for gynecologic and obstetric conditions

Aydoğmuş¹,

Kelekci²,

Şengül³

et al. 2017

TURKDERM

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Background and Design:The aim of this study is to investigate whether there can be a difference in types of scars developed on the same type of incisions due to cesarean section or benign gynecologic operations, and to examine the effect of regenerative process occurring in the puerperal period on scar formation. Materials and Methods: A total of 586 female patients aged 20-40 years, who applied to our dermatology and gynecology and obstetrics outpatient clinics, were included in this case control study. Patients who were operated due to benign gynecologic conditions were assigned to group 1 (n=293), and those who underwent cesarean section to group 2 (n=293), and the types of scars were compared. A p value of less than 0.05 was considered statistically significant. Results: Atrophic and hypertrophic scars were developed in 237 (80.9%) and 56 (19.1%) of group 1 patients, respectively. However, 245 (83.6%) of patients in group 2 had atrophic scars and 48 (16.4%) had hypertrophic scars. In terms of the type of scar distribution, no significant difference was found between the two groups (p>0.05). Patients with hypertrophic scar formation constituted 53.8% of group 1 patients and 46.2% of group 2 patients. There was no significant difference between the groups for the risk of hypertrophic scar formation (p>0.05) Conclusion: Our study concluded that there is no significant difference in scar formation on abdominal incision site between benign gynecologic surgeries performed at any period of childbearing age and cesarean section. In addition, the presence of striae, wound infection or hematoma, and duration of wound healing were found to be associated with the risk for hypertrophic scar formation in incision sites in both cesarean section and benign gynecological operations. 2017;51:12-7

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“…patch (SIS) as carrier of ADSCs significantly increases the survival of stem cells as compared to direct injection of ADSCs into the skin wounds [18]. There may be a synergistic angiogenesis promoting effects of biologic graft with stem cells, which may be important for tendon/ skin wound healing [19].…”

Section: Biomaterials In Regenerative Medicine 266mentioning

confidence: 99%

“…Furthermore, the regenerative features of MSCs and ESCs in activating the blood vessels and hair follicles formation, respectively, were suggested [35]. Combination of silk with collagen or poly(lactic-coglycolic acid) (PLGA) [18] and stem cells were evaluated in a rabbit tendon defect model [36].…”

Section: Silkmentioning

confidence: 99%

Biomaterials for Tendon/Ligament and Skin Regeneration

Cheng¹

2018

Biomaterials in Regenerative Medicine

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Tendon/ligament injury or skin injuries due to diseases, trauma, and surgery are common. Timely functional repair and tissue regeneration is a key to improve the quality of life of the patient while reducing health care cost. Tendon/ligament/skin is also enriched in a common extracellular matrix (ECM), collagen I, III, and elastin. Tissue engineering and regenerative medicine, the combination of (stem) cells, growth factors, and biomaterial scaffolds, is an emergent field, which has attracted substantial attention over the years. Biomaterials are considered the foundation of regenerative medicine. A key to find a new solution to tendon/ligament/skin healing is to synthesize new functional biomaterials, which have better biomechanical properties, biodegradability, and cell supporting properties. This chapter will review existing FDA-approved biomaterial-based therapy, as well as those in development.

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Effective Delivery of Stem Cells Using an Extracellular Matrix Patch Results in Increased Cell Survival and Proliferation and Reduced Scarring in Skin Wound Healing

Cited by 78 publications

References 19 publications

Mesenchymal Stem Cells in Chronic Wounds: The Spectrum from Basic to Advanced Therapy

Mesenchymal Stem Cells in Chronic Wounds: The Spectrum from Basic to Advanced Therapy

Factors affecting the development of scar formation in abdominal surgery performed for gynecologic and obstetric conditions

Biomaterials for Tendon/Ligament and Skin Regeneration

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