Mesenchymal Stem Cells in Chronic Wounds: The Spectrum from Basic to Advanced Therapy

Otero-Viñas, Marta; Falanga, Vincent

doi:10.1089/wound.2015.0627

Cited by 121 publications

(95 citation statements)

References 141 publications

(161 reference statements)

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“…Also, combination therapies may be less effective given the potential of additive side effects. Cell‐based therapies, such as ASCs, have been studied as anti‐fibrotic therapy in several organs (Chen et al, ; Glassberg et al, ; Haldar et al, ; Otero‐Vinas & Falanga, ; Wang et al, ). ASCs appear to act by paracrine effects to modulate multiple pathways and demonstrate an ability to adapt to the local tissue to restore homeostasis and promote tissue repair (Usunier et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…MSCs have been shown to exert anti‐inflammatory, anti‐oxidant, and immunomodulatory effects, as well as an ability to modulate pro‐fibrotic factors (Eming, Martin, & Tomic‐Canic, ; Toonkel, Hare, Matthay, & Glassberg, ; Usunier et al, ). MSCs have been investigated in pre‐clinical and clinical studies for diseases in various organs including the heart (Chen et al, ), lung (Glassberg et al, ), kidney (Wang et al, ), liver (Haldar, Henderson, Hirschfield, & Newsome, ), and skin (Ojeh, Pastar, Tomic‐Canic, & Stojadinovic, ; Otero‐Vinas & Falanga, ). Benefits of MSCs in various organs are thought to stem from their ability to adapt to the local environment and regulate its secretome (Usunier et al, ).…”

Section: Introductionmentioning

confidence: 99%

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Mesenchymal stromal cells prevent bleomycin‐induced lung and skin fibrosis in aged mice and restore wound healing

Rubio

Elliot

Wikramanayake

et al. 2018

Journal Cellular Physiology

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Fibrosis can develop in nearly any tissue leading to a wide range of chronic fibrotic diseases. However, current treatment options are limited. In this study, we utilized an established aged mouse model of bleomycin-induced lung fibrosis (BLM) to test our hypothesis that fibrosis may develop simultaneously in multiple organs by evaluating skin fibrosis and wound healing. Fibrosis was induced in lung in aged (18-22-month-old) C57BL/6 male mice by intratracheal BLM administration. Allogeneic adipose-derived mesenchymal stromal cells (ASCs) or saline were injected intravenously 24 hr after BLM administration. Full thickness 8-mm punch wounds were performed 7 days later to study potential systemic anti-fibrotic and wound healing effects of intravenously delivered ASCs. Mice developed lung and skin fibrosis as well as delayed wound closure. Moreover, we observed similar changes in the expression of known pro-fibrotic factors in both lung and skin wound tissue, including miR-199 and protein expression of its corresponding target, caveolin-1, as well as phosphorylation of protein kinase B. Importantly, ASC-treated mice exhibited attenuation of BLM-induced lung and skin fibrosis and accelerated wound healing, suggesting that ASCs may prime injured tissues and prevent end-organ fibrosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mesenchymal stromal cells prevent bleomycin‐induced lung and skin fibrosis in aged mice and restore wound healing

Rubio

Elliot

Wikramanayake

et al. 2018

Journal Cellular Physiology

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“…The safety of using iPSCs is currently being investigated, as these cells exhibit signifi cant genomic alterations following reprogramming [ 105 ] . Some of the safety concerns regarding iPSCs include teratoma formation, transplantation issues, and autoimmune responses [ 106 ] .…”

Section: Challenges and Perspectives In The Treatment Of Chronic Wounmentioning

confidence: 99%

Pathogenesis of wound healing disorders in the elderly

Makrantonaki

Wlaschek

Scharffetter‐Kochanek

2017

J Deutsche Derma Gesell

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Summary The elderly constitute the age group most susceptible to wound healing disorders and chronic wounds, the most prevalent being venous leg ulcers, pressure ulcers, and diabetic foot ulcers. However, other age‐associated diseases should also be taken into consideration in the diagnostic workup of chronic wounds, and not be underestimated. A better understanding of the pathomechanisms involved in the wound healing process is of key importance in combatting the difficulties associated with the treatment of chronic wounds. In recent decades, considerable progress has been made in the development of pioneering therapeutic strategies for chronic wounds. In this context, the use of growth factors and cytokines, tissue engineering, and cell therapy – including stem cells – have proven very promising. Nevertheless, prior to their introduction into routine clinical practice, large controlled clinical trials are required to assess the safety of these techniques.

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“…W leczeniu komórkami macierzystymi wykorzystywana jest ich zdolność do proliferacji, co pozwala na namnoże-nie niszy tych komórek oraz dyferencjacji w kierunku komórek innego typu. Znane w medycynie możliwo-ści zastosowania komórek macierzystych w dużej mierze sprowadzają się do wspomagania leczenia trudno gojących się ran [7]. Odkrycie zdolności różni-cowania się mezenchymalnych komórek macierzystych w kierunku komórek tkanki kostnej zaowocowało wprowadzeniem terapii komórkami macierzystymi w schorzeniach reumatycznych i zwyrodnieniowych stawów [8].…”

Section: W St ę Punclassified

Limbal epithelial stem cells in regeneration of corneal epithelium – clinical and molecular aspects

Sikora

Skubis

Sedlak

et al. 2018

Ann. Acad. Med. Siles.

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ST R ES ZCZ E NI EKomórki macierzyste rąbka rogówki (limbal epithelial stem cells -LESC) zlokalizowane są na granicy rogówki i spojówki. Ich funkcja polega na odbudowie rogówki poprzez zastępowanie uszkodzonych lub niefunkcjonalnych komórek. W niniejszej pracy zawarto informacje dotyczące charakterystyki LESC, opisano sposoby ich identyfikacji z wykorzystaniem markerów powierzchniowych oraz cech morfologicznych. W pracy zawarto również informacje dotyczące hodowli komórek w warunkach in vitro jako potencjalnego źródła komórek wykorzystywanych w terapii oraz poruszono zagadnienia dysfunkcji LESC spowodowanych niedoborem komórek macierzystych wywołanych różnymi czynnikami, a także przedstawiono stosowane obecnie metody leczenia LSCD (limbal stem cell deficiency). Standardowe leczenie niedoboru komórek macierzystych rąbka rogówki polega na farmakoterapii oraz transplantacji autologicznego rąbka rogówki bogatego w komórki macierzyste. W przypadku całkowitego niedoboru LESC konieczne jest wykonanie przeszczepów allogenicznych.

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Mesenchymal Stem Cells in Chronic Wounds: The Spectrum from Basic to Advanced Therapy

Cited by 121 publications

References 141 publications

Mesenchymal stromal cells prevent bleomycin‐induced lung and skin fibrosis in aged mice and restore wound healing

Mesenchymal stromal cells prevent bleomycin‐induced lung and skin fibrosis in aged mice and restore wound healing

Pathogenesis of wound healing disorders in the elderly

Limbal epithelial stem cells in regeneration of corneal epithelium – clinical and molecular aspects

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