Effective cancer immunotherapy by Ganoderma lucidum polysaccharide-gold nanocomposites through dendritic cell activation and memory T cell response

Zhang, Shulei; Pang, Guibin; Chen, Chao; Qin, Jianzhong; Yu, Huan; Liu, Yongming; Zhang, Xihui; Song, Zhiqing; Zhao, Jian; Wang, Fujun; Wang, Yangyun; Zhang, Leshuai W.

doi:10.1016/j.carbpol.2018.10.028

Cited by 103 publications

(47 citation statements)

References 30 publications

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“…GLPS also inhibited Foxp3 mRNA expression, but in this study they further demonstrated that this occurred through an increase of miR-125b expression. Zhang et al (2019) found similar results with Ganoderma lucidum polysaccharides combined with gold nanocomposites (GLP-Au). They found that the combination increased DC activation which resulted in the proliferation of CD4 + and CD8 + , and when combined with the chemotherapy drug doxorubicin, GLP-Au increased CD4 + /CD44 + T cells.…”

Section: Bufa (Formulas and Herbs That Tonify)supporting

confidence: 66%

Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells

Hoffman

et al. 2020

Front. Pharmacol.

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Traditional Chinese medicine is an accepted and integral part of clinical cancer management alongside Western medicine in China. However, historically TCM physicians were unaware of the chemical constituents of their formulations, and the specific biological targets in the body. Through HPLC, flow cytometry, and other processes, researchers now have a much clearer picture of how herbal medicine works in conjunction with the immune system in cancer therapy. Among them, the regulation of tumor-related T cells plays the most important role in modulating tumor immunity by traditional Chinese medicine. Encouraging results have been well-documented, including an increase in T cell production along with their associated cytokines, enhanced regulation of Tregs and important T cell ratios, the formation and function of Tregs in tumor microenvironments, and the promotion of the number and function of normal T Cells to reduce conventional cancer therapy side effects. Chinese herbal medicine represents a rich field of research from which to draw further inspiration for future studies. While promising agents have already been identified, the vast majority of Chinese herbal mechanisms remain undiscovered. In this review, we summarize the effects and mechanisms of specific Chinese herbs and herbal decoctions on tumor related T cells.

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Section: Bufa (Formulas and Herbs That Tonify)supporting

confidence: 66%

Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells

Hoffman

et al. 2020

Front. Pharmacol.

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“…As the main active ingredient of the Ganoderma lucidum, Ganoderma lucidum polysaccharide has significant activities such as immunoregulation,27 anti-cancer,28 anti-inflammatory,29 anti-aging,30 hyperglycemic31 and liver protection 32. In 2010, the State Food and Drug Administration (SFDA) approved Ganoderma.…”

Section: Discussionmentioning

confidence: 99%

<p>Ganoderan (GDN) Regulates The Growth, Motility And Apoptosis Of Non-Small Cell Lung Cancer Cells Through ERK Signaling Pathway In Vitro And In Vivo</p>

Wang

Gou

Hou

et al. 2019

OTT

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Background: Lung cancer is the most common malignant tumor worldwide. About 90% of lung cancers are considered non-small cell lung cancer (NSCLC). Ganoderan (GDN) is one of the components of Ganoderma lucidum polysaccharides. Ganoderan A (GDNA), Ganoderan B (GDNB) and Ganoderan C (GDNC) were three polysaccharides isolated from the Ganoderma lucidum fruiting body. Methods: Cell growth was measured by Cell Counting kit-8 and colony formation assay, while cell motility was measured by transwell assay and wound healing assay. Apoptosis was measured by flow cytometry analysis and TUNEL staining, and protein expression was detected by Western blotting and immunohistochemistry. Results: Previous studies have shown that GDNB has the effects of hyperglycemic and kidney protection. However, the role of GDNB in tumors is currently unknown. This study elaborated the role of GDNB in NSCLC and its underlying molecular mechanisms. The results exerted that GDNB inhibited the growth of H510A and A549 cells by suppressing the expression of ki67 and PCNA. Besides, transwell assay and wound healing assay showed that GDNB inhibited invasion and migration of H510A and A549 cells in a concentrationdependent manner. Moreover, Western blotting also showed that GDNB downregulated the levels of N-cadherin, vimentin and Snail in H510A and A549 cells in a dose-dependent manner, while it upregulated the level of E-cadherin. Additionally, GDNB also promoted apoptosis of H510A and A549 cells by regulating the expression of Bcl-2, Bax, cleaved caspase 3 and cleaved PARP. Animal experiments revealed that GDNB inhibited tumor growth and metastasis, and induced apoptosis of tumor cells in vivo. Mechanically, GDNB suppressed the expression of Ras and c-Myc, and decreased the phosphorylation levels of MEK1/2 and ERK1/2. Conclusion: Collectively, all data suggest that GDNB regulates the growth, motility and apoptosis of non-small cell lung cancer cells through ERK signaling pathway in vitro and in vivo.

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“…In addition to the direct killing of cancers, GL can also be used in immunotherapy against cancers. Studies have shown that GL polysaccharide-gold nanocomposite can activate dendritic cells and promote the proliferation of T cells and has a strong inhibitory effect on the proliferation and metastasis of lung cancer cells [46].…”

Section: Ten Commonly Used Herbsmentioning

confidence: 99%

Therapeutic Effects of Ten Commonly Used Chinese Herbs and Their Bioactive Compounds on Cancers

Liu

Yang

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Effective cancer therapy is one of the biggest global challenges. Conventional cancer therapies have been at the forefront of combating cancers, but more evidence showed considerable side effects, limiting their use. There are various new therapies in development, but combined approaches for treating cancer are much expected. Natural herbs had been traditionally in use for cancer therapy in most parts of the world. In this review, we have examined ten commonly used Chinese herbs that have, for centuries, shown effectiveness in treating cancers. They demonstrated the abilities to promote the apoptosis of cancer cells, inhibit their metastasis, activate the patient’s anticancer immunity, and synergistically increase the efficacy of conventional chemotherapy and radiation therapy when used in combination. Clinical experiences had proved that these herbs and their bioactive compounds were effective against a plethora of cancers through a variety of mechanisms, effectively improving patients’ quality of life without significant side effects. These advantages indicate that there are huge potentials in the development of Chinese herbs into cancer medicine as part of a promising, holistic cancer treatment modality.

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Effective cancer immunotherapy by Ganoderma lucidum polysaccharide-gold nanocomposites through dendritic cell activation and memory T cell response

Cited by 103 publications

References 30 publications

Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells

Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells

<p>Ganoderan (GDN) Regulates The Growth, Motility And Apoptosis Of Non-Small Cell Lung Cancer Cells Through ERK Signaling Pathway In Vitro And In Vivo</p>

Therapeutic Effects of Ten Commonly Used Chinese Herbs and Their Bioactive Compounds on Cancers

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