Effective adsorption of doxorubicin hydrochloride on zirconium metal-organic framework: Equilibrium, kinetic and thermodynamic studies

Al‐Hazmi, Gamil A.A.; Abou‐Melha, Khlood S.; El‐Desouky, Mohamed G.; El-Bindary, A.A.

doi:10.1016/j.molstruc.2022.132679

Cited by 82 publications

(29 citation statements)

References 43 publications

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“…Furthermore, the color shifts of the Zr‐MOF crystals, which were initially colorless but turned purple following the integration procedure, supports the incorporation of DOX into Zr‐MOF. [ 14 ]…”

Section: Resultsmentioning

confidence: 99%

“…The full‐view of XPS spectra of Zr‐MOF shows eight characteristic peaks consistent to Zr 3 s, Zr 3p, Zr 3d, Zr 4s, Zr 4p, C 1s, N 1s, and O 1s, seemingly demonstrating the presence of zirconium, carbon, nitrogen, and oxygen (Figure 5). [ 14 ] The aspect of chemical element is existing in Figure 5a shows the high revolution C 1s spectrum of Zr‐MOF. The spectra of C1s can be formfitting to three peaks, which are allocated to C‐C (43.09%) (284 eV), C‐N (38.17%) (286 eV), and C=C (38.17%) (289 eV).…”

Section: Resultsmentioning

confidence: 99%

“…The material was centrifuged and rinsed three times with distilled water until the last product had a pH of about 7, then dried overnight at 80°C. [ 14 ]…”

Section: Methodsmentioning

confidence: 99%

“…to finish crystallization before being placed in a pan and baked at 80 C overnight. The material was centrifuged and rinsed three times with distilled water until the last product had a pH of about 7, then dried overnight at 80 C. [14] 2.5 | Procedure for drug encapsulation By using an inside synthesis approach, DOX cannot be encased inside Zr-MOF. This is due to the fact that under our test circumstances, both DOX and Zr-MOF remain positively charged.…”

Section: Synthesis Of Zr-mof Nanoparticlesmentioning

confidence: 99%

“…Furthermore, the color shifts of the Zr-MOF crystals, which were initially colorless but turned purple following the integration procedure, supports the incorporation of DOX into Zr-MOF. [14] 3.1.1 | X-ray diffraction patterns Figure 1 displays the X-ray diffraction (XRD) patterns of Zr-MOF and the broad peaks can be detected. [22] In XRD pattern, the appearance of broad peaks between angles (2θ) of 20 to 40 indicates the amorphous nature of the Zr-MOF and sharp peaks-crystalline nature.…”

Section: Characterization Of Zr-mof and Dox Encapsulated In Zr-mof Na...mentioning

confidence: 99%

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Metal–organic frameworks encapsulated with an anticancer compound as drug delivery system: Synthesis, characterization, antioxidant, anticancer, antibacterial, and molecular docking investigation

El‐Bindary

El‐Desouky

El-Bindary

2022

Applied Organom Chemis

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Metal organic framework (MOF) hybrid materials could be one of the answers in this investigation. We describe a simple and effective encapsulation of doxorubicin (DOX), an anticancer drug, inside Zr-MOF, which have been little studied as drug delivery organizations. We investigated the measured release of the drug from Zr-MOF in response to external incentives such as pH changes and interaction with biomimetic schemes. Zr-MOF with encapsulated doxorubicin (DOX@Zr-MOF) can be manufactured in one pot by addition the anticancer medication DOX to the reaction combination. They demonstrated pH-responsive medication release and cancer cell killing capability. MOFs can be designed as multifunctional distribution vehicles for a diversity of loads, including medicinal and imaging agents, using our simple one-pot approach.Fourier transform infrared (FTIR), X-ray diffraction, scanning electron microscopy, and N 2 sorption isotherm were used to analyze MOF and the developed drug delivery (DOX@Zr-MOF) scheme. It investigated the effects of MOF and a bespoke drug delivery system on the feasibility of patient breast as well as liver tumor cell lines. At pH 5, the trapped drug can be released more quickly than at pH 7.4. Zr-MOF nanoparticles had modest cytotoxicity; however, DOX@Zr-MOF has higher cytotoxicity in MCF-7 and HepG-2 cells than DOX at concentrations greater than 31.25 μg ml À1 . These results were discovered

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…The material was centrifuged and rinsed three times with distilled water until the last product had a pH of about 7, then dried overnight at 80°C. [ 14 ]…”

Section: Methodsmentioning

confidence: 99%

Section: Synthesis Of Zr-mof Nanoparticlesmentioning

confidence: 99%

Section: Characterization Of Zr-mof and Dox Encapsulated In Zr-mof Na...mentioning

confidence: 99%

See 3 more Smart Citations

Metal–organic frameworks encapsulated with an anticancer compound as drug delivery system: Synthesis, characterization, antioxidant, anticancer, antibacterial, and molecular docking investigation

El‐Bindary

El‐Desouky

El-Bindary

2022

Applied Organom Chemis

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Superior and effective adsorption of amoxicillin by using novel metal organic framework and its composite: Thermodynamic, kinetic, and optimization by Box–Behnken design

Sallam

Alorabi

Almotairy

et al. 2023

Applied Organom Chemis

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Exploring the potential of silver metal organic frameworks (Ag-MOF), we modified it with sulfanilamide (Ag-MOF-NH 2 ) to create an efficient means for the adsorption of amoxicillin (AMX) from aqueous solutions. We characterized this new material with various imaging and analyzation techniques. Investigations into adsorption were conducted with varying solution pH, contact time, and adsorbent dosages. Moreover, the kinetics and adsorption isotherms were also tested by different models. Results revealed that equilibrium was reached between the antibiotic and the adsorbents within 100 min, with 1.93 and 2.63 mmolÁg À1 as the maximum adsorption capacities of Ag-MOF and Ag-MOF-NH 2 , respectively. The adsorption of AMX onto the adsorbents is closely in line with the pseudo-second-order kinetic model, intraparticle-diffusion model, and Langmuir isotherm, suggesting that the surface of the adsorbent is homogeneous and that the highest binding sites are filled first. By utilizing this data, an engaging conclusion can be drawn: the process of adsorption is efficient and effective. Optimizing adsorption results with Box-Behnken design (BBD) and Response Surface Methodology (RSM) produced impressive outcomes. Additionally, experiments were conducted on non-buffered AMX solutions at various NaNO 3 concentrations to ascertain the influence of the electrolytes' composition. Surprisingly, its capacity to take up the element was affected by different concentrations and has ability to be reused several times by capacity above 80% for up to four cycles. Discovering the intricate mechanisms behind AMX adsorption, such as electrostatic forces, π-π interactions, H-bonding, and pore filling, proves to be an invaluable asset in reducing its concentration from real water samples. The mighty potential of Ag-MOF and Ag-MOF-NH 2 makes them excellent adsorbents with removal efficiencies ranging between 86% and 97% making them ideal for industrial uses and protecting our environment.

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Adsorption of Ibuprofen as a pharmaceutical pollutant from aqueous phase using zinc oxide nanoparticles: Green synthesis, batch adsorption, and biological activities

Alibrahim

2023

J of Molecular Recognition

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Recent interest has focused on the biosynthesis of metal nanoparticles (NPs), particularly from plants. The production of precipitate served as an early indicator of the presence in the present study's use of ZnO NPs green synthesis of these particles, which was further validated by; Fourier transform infrared spectroscopy, x‐ray diffraction. Additionally, the Brunauer–Emmett–Teller was used to calculate the surface area, which came out to be 119.12 m2/g. Since the true effects of new pollutants, including medicines, on the environment and human health are not well understood, their presence in aquatic systems poses a severe hazard. For this reason, the antibiotic Ibuprofen (IBP) was absorbable to ZnO‐NPs in this search. As opposed to fitting to Langmuir isothermally, the adsorption process was discovered to be pseudo‐second‐order kinetically, and the reaction was determined to be a chemisorption process. The process was endothermic and spontaneous, according to thermodynamic studies. Maximizing IBP removal from aqueous solution required the use of a Box–Behnken surface statistical design with four components, four levels, and response surface modeling. Solution pH, IBP concentration, duration, and dose were the four parameters that were utilized. The regeneration process, which is employed for five cycles with excellent efficiency, is the best benefit of using ZnO‐NPs. Examine the elimination of pollutants from actual samples as well. However, the adsorbent is quite effective at reducing biological activity. At high concentrations of ZnO‐NPs demonstrated notable antioxidant activity and Red Blood Cell (RBC) hemocompatibility and no discernible hemolysis was seen. ZnO‐NPs demonstrated a notable percent suppression of α‐amylase up to 53.6% at 400 μg/mL, and so displayed potential as an antidiabetic. Cyclooxygenase was suppressed by ZnO‐NPs in an anti‐inflammatory test (COX‐1 & COX‐2) up to 56.32% and 52.04% at a concentration of 400 μg/mL, respectively. Significant anti‐Alzheimer potential was demonstrated by ZnO‐NPs at 400 μg/mL by inhibiting Acetyl cholinesterase and Butyl cholinesterase up to 68.98 ± 1.62% and 62.36%, respectively. We concluded that guava extract is helpful for ZnO‐NP reduction and capping. The bioengineered NPs could prevent Alzheimer's, diabetes, and inflammation and were biocompatible.

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Effective adsorption of doxorubicin hydrochloride on zirconium metal-organic framework: Equilibrium, kinetic and thermodynamic studies

Cited by 82 publications

References 43 publications

Metal–organic frameworks encapsulated with an anticancer compound as drug delivery system: Synthesis, characterization, antioxidant, anticancer, antibacterial, and molecular docking investigation

Metal–organic frameworks encapsulated with an anticancer compound as drug delivery system: Synthesis, characterization, antioxidant, anticancer, antibacterial, and molecular docking investigation

Superior and effective adsorption of amoxicillin by using novel metal organic framework and its composite: Thermodynamic, kinetic, and optimization by Box–Behnken design

Adsorption of Ibuprofen as a pharmaceutical pollutant from aqueous phase using zinc oxide nanoparticles: Green synthesis, batch adsorption, and biological activities

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