Effect on Routine and Special Coagulation Testing Values of Citrate Anticoagulant Adjustment in Patients With High Hematocrit Values

Marlar, Richard A.; Potts, Robyn M.; Marlar, Audrey A.

doi:10.1309/rrqk-t2je-yv33-d19d

Cited by 6 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, as has been proven in human medicine, hemostatic tests may be influenced by plasma volume and hematocrit values. In this way, lower hematocrit values could result in a hypercoagulable state, 13 whereas overhydration secondary to fluid therapy could lead dilutional coagulopathy 14 . In our study, these effects can be excluded, because both donkeys and horses had similar PCVs and total plasma protein concentrations that were within the normal reference ranges, and fluids were not administered, excluding any dilutional effect.…”

Section: Discussionmentioning

confidence: 99%

Coagulation Profiles of Healthy Andalusian Donkeys are Different than Those of Healthy Horses

Mendoza

Pérez-Écija

Monreal

et al. 2011

Veterinary Internal Medicne

View full text Add to dashboard Cite

Background: Coagulation disorders are frequently diagnosed, especially in hospitalized equidae, and result in increased morbidity and mortality. However, hemostatic reference intervals have not been established for donkeys yet.Objectives: To determine whether the most common coagulation parameters used in equine practice are different between healthy donkeys and horses.Animals: Thirty-eight healthy donkeys and 29 healthy horses. Methods: Blood samples were collected to assess both coagulation and fibrinolytic systems by determination of platelet count, fibrinogen concentration, clotting times (prothrombin time [PT] and activated partial thromboplastin time [aPTT]), fibrin degradation products (FDP) and D-Dimer concentrations.Results: PT and aPTT in donkeys were significantly (P o .05) shorter than those of horses. In contrast, FDP and D-Dimer concentrations were significantly (P o .05) higher in donkeys than in horses.Conclusions and Clinical Importance: The coagulation parameters most commonly determined in equine practice are different in donkeys compared with horses. Thus, the use of normal reference ranges reported previously for healthy horses in donkeys might lead to a misdiagnosis of coagulopathy in healthy donkeys, and unnecessary treatments in sick donkeys. This is the first report of normal coagulation profile results in donkeys, and further studies are warranted to elucidate the physiological mechanisms of the differences observed between donkeys and horses.

show abstract

Section: Discussionmentioning

confidence: 99%

Coagulation Profiles of Healthy Andalusian Donkeys are Different than Those of Healthy Horses

Mendoza

Pérez-Écija

Monreal

et al. 2011

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…A genetic polymorphism could result in an “inappropriate” test result (ie, a normal test in a phenotypically abnormal patient or an abnormal test in a phenotypically normal patient) . Alterations in hematocrit due to various conditions, such as anemia, dehydration, and polycythemia, may lead to inappropriate results (ie, PFA‐100, inappropriate citrate concentration) . Exercise may lead to increased procoagulant factors, as well as increased von Willebrand factor .…”

Section: Biological Causes Of Spurious Resultsmentioning

confidence: 99%

Sources and solutions for spurious test results in coagulation

Marlar

Rollins‐Raval

2019

Int J Lab Hematology

Self Cite

View full text Add to dashboard Cite

In the coagulation laboratory, much emphasis has been placed on rapid and accurate testing; however, spurious results that are inaccurate and do not reflect the actual status of the patient can potentially lead to an incorrect diagnosis and altered intervention. Errors in coagulation results and interpretation can occur at any point of the process from obtaining the specimen to interpretation and use of the result by the clinician. The main sources of error include the patient's biological and preanalytical variation, analytical testing, and postanalytical use of the reported result(s). This article reviews various sources of error leading to spurious results, providing methods to recognize these aberrant results and presenting solutions for minimizing their occurrence.

show abstract

“…Patients on intravenous UFH over a range of therapeutic doses but not influenced by other anticoagulants (INR < 1.3) are used in this study [5,8,12,17,18]. The baseline APTT and PT values are normal unless otherwise stated.…”

Section: Patient Samples and Sample Processingmentioning

confidence: 99%

“…All samples are from venous blood specimens collected in 3.2% buffered sodium citrate anticoagulant vacutainers [8,18]. In all comparison studies, the same manufacturer of blood tubes is used at all of the sites.…”

Section: Patient Samples and Sample Processingmentioning

confidence: 99%

The effect of instrumentation and laboratory site on the accuracy of the APTT‐based heparin therapeutic range

Marlar

Gausman

2012

Int J Lab Hematology

View full text Add to dashboard Cite

Summary Background Monitoring of unfractionated heparin therapy by activated partial thromboplastin time using the ex vivo method for determining the heparin therapeutic range (HTR) is the standard of practice. Many extrinsic and intrinsic factors influence accuracy of the HTR. This study investigates the affect of instrumentation and laboratory site on the accuracy of the ex vivo HTR method. Methods Patients on unfractionated heparin are used to determine the HTR by published guidelines. Various instruments and different laboratories are compared to investigate the affect of these variables on the HTR. Results The HTR is the same when the same model of instrument or even different models (same methodology) are used in the same laboratory. However, a significant clinical difference is observed when different hospital laboratories using same lot and instrument model are compared. Conclusions The ex vivo method for HTR is the best protocol currently available. The HTR should be determined and averaged on all of the same method instruments used in the laboratory. However, determination of the HTR in different laboratories should not be shared.

show abstract

Effect on Routine and Special Coagulation Testing Values of Citrate Anticoagulant Adjustment in Patients With High Hematocrit Values

Cited by 6 publications

References 0 publications

Coagulation Profiles of Healthy Andalusian Donkeys are Different than Those of Healthy Horses

Coagulation Profiles of Healthy Andalusian Donkeys are Different than Those of Healthy Horses

Sources and solutions for spurious test results in coagulation

The effect of instrumentation and laboratory site on the accuracy of the APTT‐based heparin therapeutic range

Contact Info

Product

Resources

About