Effect on postural sway of various benzodiazepine tranquillizers.

Patat, Alain; Foulhoux, P

doi:10.1111/j.1365-2125.1985.tb02792.x

Cited by 32 publications

(21 citation statements)

References 23 publications

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“…The deficit in psychomotor skills peaked 2 to 4 h after dosing and was persistent, being present at the last determination, 8 h post-dosing, for some of the tests used. Similar impairment had already been demonstrated up to 12 h post-dose [12,13,[15][16][17]28]. Lorazepam also impaired short-term memory, as demonstrated by the decrease in the number of words correctly remembered after the first immediate free recall or throughout the 10 learning trials and by the increase in the reaction time recorded in the Steinberg memory scanning test.…”

Section: Discussionsupporting

confidence: 71%

Lack of interaction between a new antihistamine, mizolastine, and lorazepam on psychomotor performance and memory in healthy volunteers.

Patat¹,

Perault²,

Vandel³

et al. 1995

Brit J Clinical Pharma

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1 The possible interaction between ao new H1 antihistamine, mizolastine, and lorazepam was assessed in a randomised, double-blind, cross-over, placebo-controlled study involving 16 healthy young male volunteers who received mizolastine 10 mg or placebo once daily for 8 days with a 1 week wash-out interval. The interaction of mizolastine, at steady-state, with a single oral dose of lorazepam or placebo was assessed on days 6 or 8 of each treatment period. 2 Psychomotor performance and cognitive function were evaluated using objective tests (critical flicker fusion threshold, choice reaction time, tapping, arithmetic calculation, body sway) and self-ratings (visual analogue scale, ARCI) before and at 2, 4, 6 and 8 h after dosing. Short-term memory (Stemnberg memory scanning, immediate free recall of a word list) and long-term memory (delayed free recall and recognition of words and pictures) were assessed before and at 3 h after dosing. Pharmacodynamic interactions were evaluated by repeated measures ANOVA in a 2 x 2 factorial interaction model. 3 Mizolastine, 10 mg once daily, at steady-state, was devoid of sedation and detrimental effect on skilled performance and memory. 4 In contrast, a single 2 mg dose of lorazepam produced marked impairment of psychomotor performance, cognitive functions (significant reduction in flicker fusion threshold, tapping and arithmetic calculation and increase in reaction times and body sway) and subjective sedation from 2 to 8 h after dosing. In addition, lorazepam induced an anterograde amnesia, characterised by a decrease in delayed free recall and recognition, and a deficit in short term memory. 5 Mizolastine did not potentiate the detrimental effect of lorazepam. The time course and the intensity of the disruption induced by the combination of lorazepam and mizolastine closely paralleled the changes induced by lorazepam alone.Keywords mizolastine lorazepam antihistamine benzodiazepine interaction psychomotor performance memory cognitive function psychopharmacology

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Section: Discussionsupporting

confidence: 71%

Lack of interaction between a new antihistamine, mizolastine, and lorazepam on psychomotor performance and memory in healthy volunteers.

Patat¹,

Perault²,

Vandel³

et al. 1995

Brit J Clinical Pharma

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“…Drugs which impair performance, such as oxazepam and diazepam, modify body sway, whereas similar drugs without obvious behavioural effects, such as clobazam, dipotassium chlorazepate and desmethyldiazepam tend to leave body sway unaffected (Baron et al, 1977;Sittig et al, 1982;Patat & Foulhoux, 1985). However, the effect of atenolol could have been mediated through the peripheral control of posture, since impaired psychomotor performance is not an obvious effect of this drug (Nicholson & Wright, 1980;Currie et al, 1988).…”

Section: Electroencephalogramsmentioning

confidence: 99%

Central effects of beta‐adrenoceptor antagonists. II‐ Electroencephalogram and body sway.

Nicholson

Wright

Zetlein

et al. 1988

Brit J Clinical Pharma

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1 Effects of the P-adrenoceptor antagonists, propranolol (40, 80 and 160 mg) and atenolol (50 and 100 mg) on the electroencephalogram and on body sw#y, were studied in 12 healthy male subjects. The study was double-blind, and included two placebos and an active control, oxazepam (15 mg). Medication was ingested at 11.00 h, and assessments were made before, and at 2 h and 4 h after ingestion. 2 All doses of both ,B-adrenoceptor antagonists modified the electroencephalogram, and the changes reported were statistically significant at probability levels of less than 5%. The circadian rise in ot activity was reduced by both 3-adrenoceptor antagonists as well as by oxazepam. Atenolol also decreased 1B activity. 3 Body sway was modified by atenolol and oxazepam (P < 0.05). The increase with oxazepam was most marked in the low frequency component (0.05-2.25 Hz) of the spectrum, while atenolol modified only the component of higher frequency (2.25-4.0 Hz). 4 These observations suggest that propranolol and atenolol have a sedative effect, and that hydrophilic antagonists are unlikely to be free of central activity. The changes in body sway could imply that peripheral mechanisms may be modified at least with atenolol.

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“…The changes in the body's center of pressure reflect an integration of somatosensory function, with and without visual function, and the static component of vestibular function provided by the otolith organs of the inner ear. These measurements have been used previously to analyze postural stability after alcohol ingestion (Kubo, Sakata, Matsunaga, Koshimune, Sakai, Ameno, & Ijiri, 1989), benzodiazepine administration (Patat & Foulhoux, 1985), and prolonged exposure to microgravity (Collins, De Luca, Pavlik, Roy, & Emley, 1995). The participants' posture was heels together, feet open at a 30-deg angle, and hands at sides, much like a relaxed version of the military position of attention.…”

Section: Visual: Smooth Pursuit Trackingmentioning

confidence: 99%

An Assessment of Modafinil for Vestibular and Aviation-Related Effects

Eddy¹,

Gibbons²,

Storm³

et al. 2005

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REPORT DOCUMENTATION PAGEOMB maintaining the data needed, and completing and reviewing this collection of information, Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information , 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE (DD-MM-YYYY)2. REPORT TYPE 3. DATES COVERED (From -To) October Approved for public release; distribution unlimited. SUPPLEMENTARY NOTES ABSTRACTThe goal of this study was to provide data concerning both the efficacy and the safe-to-fly dosage of a relatively unique compound, modafinil. Previous studies have indicated that modafinil holds promise as an effective wake-promoting agent for military personnel assigned to sustained operations without the common side effects associated with amphetamine-like substances. The present research was conducted to examine whether 200 or 400 mg doses of modafinil have any effect upon human vestibular functioning at night, to verify its cognitive enhancement capabilities during a short-term, sleep-loss setting, and to document the presence/absence of subjective symptoms. Other measures were investigated for possible effects of over-confidence or dehydration. ....................................................................................... .................................................................................... .............................................................................. ............................................................................................ 34 Other Physiological M easures ....................................................................................... 35 Oral Temperature ....................................................................................................... 35 Heart Rate ....................................................................................................................... 35 Blood Pressure .......................................................................................................... .................................................................................................................. 38 Urine Assay for M odafinil .......................................................................................... 39 DISCUSSION .................................................................................................................... m easures ..................................................................................................... 31 Figure 10. Representative scatter plots of observed performance plotted against participant estim...

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Effect on postural sway of various benzodiazepine tranquillizers.

Cited by 32 publications

References 23 publications

Lack of interaction between a new antihistamine, mizolastine, and lorazepam on psychomotor performance and memory in healthy volunteers.

Lack of interaction between a new antihistamine, mizolastine, and lorazepam on psychomotor performance and memory in healthy volunteers.

Central effects of beta‐adrenoceptor antagonists. II‐ Electroencephalogram and body sway.

An Assessment of Modafinil for Vestibular and Aviation-Related Effects

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