Effect of μ-opioid receptor A118G polymorphism on the ED50 of epidural sufentanil for labor analgesia

The Impact of Genetics and Other Factors on Intra- and Post-partum Pain

“…These data demonstrated a similar pharmacogenetic association of A118G genotype with neuraxial opioid potency during labor analgesia, although with a more modest clinical effect [23].…”

“…Lower ED50 in women with G118 allele [23] OPRM1 A118G Labor pain and progress (N = 65, North American)…”

Pain and genetics

“…The results demonstrated a significant difference between poor metabolizers, extensive metabolizers, and ultra-rapid metabolizers area under the curves (AUCs) of morphine with a median (range) AUC of 0.5 mg h/l (0.5-2.8) in poor metabolizers, 11 mg h/l (5-17) mg h/l in extensive metabolizers, and 16 (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24) mg h/l in ultra-rapid metabolizers (P ¼ 0.02). The O-demethylation of codeine to morphine is mediated by CYP2D6.…”

Pharmacogenetics in Clinical Practice

“…OPRM1 is known to display several single nucleotide polymorphisms (SNPs). There is great interest in one common polymorphism of OPRM1, p. 118A/G, because the G118 allele has been shown to reset in the substitution of amino acid asparagine with aspartate at position 40 (Camorcia et al, 2012). Due to this discovery many clinical trials were conducted with following findings.…”