Effect of Γ-aminobutyric acid on kidney injury induced by renal ischemia-reperfusion in male and female rats: Gender-related difference

Vafapour, Marzieh; Nematbakhsh, Mehdi; Monajemi, Ramesh; Mazaheri, Safoora; Talebi, Ardeshir; Talebi, Nahid; Shirdavani, Soheyla

doi:10.4103/2277-9175.161585

Cited by 7 publications

(5 citation statements)

References 46 publications

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“…reported that GABA decreased the serum level of Cr in renal ischemic/reperfusion in female, but not in male rats. [ 30 ] In clinical medicine, the causes of acute kidney injury are often divided into prerenal, intra renal, and postrenal. The BUN/Cr ratio is used to distinguish prerenal dysfunction,[ 31 ] and it is also considered as a renal function indicator.…”

Section: Discussionmentioning

confidence: 99%

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The Role of Gamma Amino Butyric Acid in Cisplatin-induced Nephrotoxicity in Streptozotocin-induced Diabetic Rats

et al. 2017

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Background:Diabetes mellitus can change the risk of developing cancer. Cisplatin (CP) is a common antineoplastic drug. The major side effect of CP is nephrotoxicity. Gamma amino butyric acid (GABA) is an antioxidant agent that may have a protective role against CP-induced nephrotoxicity. The aim of the present study was to investigate the role of GABA in CP-induced nephrotoxicity in hyperglycemic male and female rats.Materials and Methods:Sixty male and female Wistar diabetic rats were used in ten experimental groups. GABA alone groups received GABA (50 μmol/kg/d i.p.) for 12 days. CP alone groups received CP (2.5 mg/kg/d i.p.) for 6 days. Other groups received GABA in the form of therapy (T) + CP, prophylaxis (P) + CP, and prophylaxis-treatment (PT) + CP. Finally, blood samples were obtained, and animals were killed for kidney tissue investigation.Results:In female rats, the serum levels of creatinine (Cr) did not change by GABA rather than CP and also there were no significant changes in blood urea nitrogen to creatinine ratio (BUN/Cr). In male rats, plasma Cr level increased by GABA (P) and (T). Body weight loss was significantly different among groups (P < 0.05). BUN/Cr ratio significantly increased in CP and GABA (PT) + CP groups. In two genders, plasma Cr level significantly decreased in CP groups (P < 0.05). The kidney levels of malondialdehyde enhanced significantly in CP groups.Conclusion:Hyperglycemia has protective effect against CP-induced nephrotoxicity. GABA did not change this effect in female, but in male in the form of PT, GABA maintained it.

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Section: Discussionmentioning

confidence: 99%

“…reported,[ 44 ] while GABA in the form of prophylaxis and therapy, decreased UW, and this finding was in agreement with other documents. [ 30 ] MDA, as the final product of lipid peroxidation, is one of the biomarkers of oxidative stress. [ 45 ] CP administration is leading to lipid peroxidation and increase the MDA level.…”

Section: Discussionmentioning

confidence: 99%

The Role of Gamma Amino Butyric Acid in Cisplatin-induced Nephrotoxicity in Streptozotocin-induced Diabetic Rats

et al. 2017

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“…Meanwhile, the increases in alanine amino transferase and aspartate amino transferase activities, urea and creatinine levels, malondialdehyde and advanced oxidation protein levels, and oxidative damage to the kidney tissues induced by γ-irradiated- and streptozotocin-treated rats were markedly attenuated by Gaba administration in rats [122]. Especially, Gaba was observed to ameliorate kidney injury induced by renal ischemia/reperfusion injury in a gender dependent manner [123]. These results emphasized the protective effect of Gaba against the renal damage involving in renal failure.…”

Section: Pharmaceutical Properties Of Gabamentioning

confidence: 99%

An Updated Review on Pharmaceutical Properties of Gamma-Aminobutyric Acid

2019

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Gamma-aminobutyric acid (Gaba) is a non-proteinogenic amino acid that is widely present in microorganisms, plants, and vertebrates. So far, Gaba is well known as a main inhibitory neurotransmitter in the central nervous system. Its physiological roles are related to the modulation of synaptic transmission, the promotion of neuronal development and relaxation, and the prevention of sleeplessness and depression. Besides, various pharmaceutical properties of Gaba on non-neuronal peripheral tissues and organs were also reported due to anti-hypertension, anti-diabetes, anti-cancer, antioxidant, anti-inflammation, anti-microbial, anti-allergy, hepato-protection, reno-protection, and intestinal protection. Therefore, Gaba may be considered as potential alternative therapeutics for prevention and treatment of various diseases. Accordingly, this updated review was mainly focused to describe the pharmaceutical properties of Gaba as well as emphasize its important role regarding human health.

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“…In addition, the effect of GABA on renal I/R injury exhibited gender-related difference. GABA treatment can attenuate pathological renal parameters (blood creatinine and urea nitrogen, kidney weight, and renal level of malondialdehyde) in female rats rather than male rats [176]. However, it was intriguing that GABA was unable to protect renal I/R injury in ovariectomized rats whether estradiol was administrated or not [177].…”

Section: Roles Of Gaba In I/r Injuries Of Other Organs Outside Of mentioning

confidence: 99%

The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs

Chen

Zhou

Jian

et al. 2019

Oxidative Medicine and Cellular Longevity

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Ischemia-reperfusion (I/R) injury is a common pathological process, which may lead to dysfunctions and failures of multiple organs. A flawless medical way of endogenous therapeutic target can illuminate accurate clinical applications. γ-Aminobutyric acid (GABA) has been known as a marker in I/R injury of the central nervous system (mainly in the brain) for a long time, and it may play a vital role in the occurrence of I/R injury. It has been observed that throughout cerebral I/R, levels, syntheses, releases, metabolisms, receptors, and transmissions of GABA undergo complex pathological variations. Scientists have investigated the GABAergic enhancers for attenuating cerebral I/R injury; however, discussions on existing problems and mechanisms of available drugs were seldom carried out so far. Therefore, this review would summarize the process of pathological variations in the GABA system under cerebral I/R injury and will cover corresponding probable issues and mechanisms in using GABA-related drugs to illuminate the concern about clinical illness for accurately preventing cerebral I/R injury. In addition, the study will summarize the increasing GABA signals that can prevent I/R injuries occurring in peripheral organs, and the roles of GABA were also discussed correspondingly.

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Effect of Γ-aminobutyric acid on kidney injury induced by renal ischemia-reperfusion in male and female rats: Gender-related difference

Cited by 7 publications

References 46 publications

The Role of Gamma Amino Butyric Acid in Cisplatin-induced Nephrotoxicity in Streptozotocin-induced Diabetic Rats

The Role of Gamma Amino Butyric Acid in Cisplatin-induced Nephrotoxicity in Streptozotocin-induced Diabetic Rats

An Updated Review on Pharmaceutical Properties of Gamma-Aminobutyric Acid

The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs

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