Effect of β-glucan originated from Aureobasidium pullulans on asthma induced by ovalbumin in mouse

Ku, Sae Kwang; Kim, Joo Wan; Cho, Hyung Rae; Kim, Ki Young; Min, You; Park, Jong Hyun; Park, Ji Ha; Seo, Bu Il; Roh, Seong Soo

doi:10.1007/s12272-012-0615-8

Cited by 26 publications

(30 citation statements)

References 43 publications

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“…β-glucan exhibits immune stimulatory activity, and is consumed as a supplement in many countries. Also, A. pullulans culture supernatant is believed to exhibit beneficial effects in delaying the onset of a number of diseases, and has been reported to exhibit antitumor, antiallergy and anti-infectious disease activities in mouse models [58][59][60][61][62][63][64][65][66][67][68]. An interesting review by Li et al [69] on Aureobasidium spp.…”

Section: Pullulan and Other Polysaccharidesmentioning

confidence: 99%

The Multiple and Versatile Roles of Aureobasidium pullulans in the Vitivinicultural Sector

Bozoudi

Tsaltas

2018

Fermentation

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The saprophytic yeast-like fungus Aureobasidium pullulans has been well documented for over 60 years in the microbiological literature. It is ubiquitous in distribution, being found in a variety of environments (plant surfaces, soil, water, rock surfaces and manmade surfaces), and with a worldwide distribution from cold to warm climates and wet/humid regions to arid ones. Isolates and strains of A. pullulans produce a wide range of natural products well documented in the international literature and which have been regarded as safe for biotechnological and environmental applications. Showing antagonistic activity against plant pathogens (especially post-harvest pathogens) is one of the major applications currently in agriculture of the fungus, with nutrient and space competition, production of volatile organic compounds, and production of hydrolytic enzymes and antimicrobial compounds (antibacterial and antifungal). The fungus also shows a positive role on mycotoxin biocontrol through various modes, with the most striking being that of binding and/or absorption. A. pullulans strains have been reported to produce very useful industrial enzymes, such as β-glucosidase, amylases, cellulases, lipases, proteases, xylanases and mannanases. Pullulan (poly-α-1,6-maltotriose biopolymer) is an A. pullulans trademark product with significant properties and biotechnological applications in the food, cosmetic and pharmaceutical industries. Poly (β-l-malic acid), or PMA, which is a natural biopolyester, and liamocins, a group of produced heavy oils and siderophores, are among other valuable compounds detected that are of possible biotechnological use. The fungus also shows a potential single-cell protein source capacity with high levels of nucleic acid components and essential amino acids, but this remains to be further explored. Last but not least, the fungus has shown very good biocontrol against aerial plant pathogens. All these properties are of major interest in the vitivinicultural sector and are thoroughly reviewed under this prism, concluding on the importance that A. pullulans may have if used at both vineyard and winery levels. This extensive array of properties provides excellent tools for the viticulturist/farmer as well as for the oenologist to combat problems in the field and create a high-quality wine.

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Section: Pullulan and Other Polysaccharidesmentioning

confidence: 99%

The Multiple and Versatile Roles of Aureobasidium pullulans in the Vitivinicultural Sector

Bozoudi

Tsaltas

2018

Fermentation

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“…In addition, glucan manifested significant effects in prevention or modulation of infectious diseases (Renzetti et al, 2009;Ramberg et al, 2010;Novak and Vetvicka, 2008). Some recent observations showed that glucan has palative anti-allergic effects (Ku et al, 2012), even in children with respiratory problems (Jesenak et al, 2013b). The possibility that these effects might be manifested via decreasing proinflammatory cytokines such as IL-6 and TNF-α and increasing of secretion of IL-10 and accession of cellular antioxidants was suggested (Senoglu et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Placebo-Driven Clinical Trials of Transfer Point Glucan #300 in Children With Chronic Respiratory Problems: Iii. Clinical Findings

Větvička

Richter²,

Svozil³

et al. 2013

American Journal of Immunology

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The role of glucan in stimulation of immune reactions has been studied for decades. In this report we focused on the effects of orally administered glucan in children with chronic respiratory problems. We measured the physical endurance using a 6MWT test and the levels of eNO in 50 children aged 8-12 years and evaluated the effects of 100 mg/d oral dose of glucan. We found significant improvements in physical indurance and exhaled nitric oxide in glucan-treated children. In addition, strong improvements in general conditions were found. Short-term oral application of natural immunomodulator β-glucan enhancers the overall health and regulation of energetic metabolism in children with chronic respiratory problems.

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“…The exopolymers from Aureobasidium pullulans SM2001 (E‐ AP ‐SM2001) may be able to prevent these sun‐exposure‐related events. Purified E‐ AP ‐SM2001 consists of 1.7% β‐1,3/1,6‐glucan, fibrous polysaccharides and other organic materials, such as amino acids and mono‐ and di‐unsaturated fatty acids (linoleic and linolenic acids) . Recent studies have shown that E‐ AP ‐SM2001 shows anti‐osteoporotic , anti‐inflammatory and immunomodulatory effects .…”

mentioning

confidence: 99%

Inhibition of UVB‐Induced Skin Damage by Exopolymers from Aureobasidium pullulans SM‐2001 in Hairless Mice

Kim

Park

Lee

et al. 2014

Basic Clin Pharma Tox

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Because antioxidants from natural sources may be an effective approach to the treatment and prevention of UV radiation-induced skin damage, the effects of purified exopolymers from Aureobasidium pullulans SM-2001 ('E-AP-SM2001') were evaluated in UVB-induced hairless mice. E-AP-SM2001 consists of 1.7% b-1,3/1,6-glucan, fibrous polysaccharides and other organic materials, such as amino acids, and mono-and di-unsaturated fatty acids (linoleic and linolenic acids) and shows antiosteoporotic and immunomodulatory effects, through antioxidant and anti-inflammatory mechanisms. Hairless mice were treated topically with vehicle, E-AP-SM2001 stock and two and four times diluted solutions once per day for 15 weeks against UVB irradiation (three times per week at 0.18 J/cm 2 ). The following parameters were evaluated in skin samples: myeloperoxidase (MPO) activity, cytokine levels [interleukin (IL)-1b and IL-10], endogenous antioxidant content (glutathione, GSH), malondialdehyde (MDA) levels, superoxide anion production; matrix metalloproteases (MMP-1, -9 and -13), GSH reductase and Nox2 (gp91phox) mRNA levels, and immunoreactivity for nitrotyrosine (NT), 4-hydroxynonenal (HNE), caspase-3, and cleaved poly (ADP-ribose) polymerase (PARP). Photoageing was induced by UVB irradiation through ROS-mediated inflammation, which was related to the depletion of endogenous antioxidants, activation of MMPs and keratinocyte apoptosis. Topical treatment with all three doses of E-AP-SM2001 and 5 nM myricetin attenuated the UV-induced depletion of GSH, activation of MMPs, production of IL-1b, the decrease in IL-10 and keratinocyte apoptosis. In this study, E-AP-SM2001 showed potent inhibitory effects against UVB-induced skin photoageing. Thus, E-AP-SM2001 may be useful as a functional ingredient in cosmetics, especially as a protective agent against UVB-induced skin photoageing.The skin is a vital organ, preserving water within the body, preventing infection and protecting against ultraviolet (UV) radiation. Skin acts as a physical barrier but also regulates the immune system and produces hormones and neurotransmitters [1,2].UVB radiation from sunlight is a major extrinsic factor in skin ageing [3]. When skin is damaged due to repeated exposure to UV radiation, photoageing occurs in skin tissue, resulting in wrinkled, lax and coarse skin with uneven pigmentation and brown spots [4,5]. UV radiation-induced skin damage is characterized by histological changes, including damage to collagen fibres, excessive deposition of abnormal elastic fibres and increased levels of glycosaminoglycans [4,6]. These alterations were found in the dermal connective tissues of photoaged skin in histological and ultrastructural studies [4,7]. Chronic exposure of the skin to UV radiation, particularly to UVB (290-320 nm), has been shown to induce clinical and histological damage as a result of simultaneous skin destruction and repair [8]. UVB light is absorbed mainly in the epidermis, which consists primarily of keratinocytes [9]. Naturally aged skin is ...

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Effect of β-glucan originated from Aureobasidium pullulans on asthma induced by ovalbumin in mouse

Cited by 26 publications

References 43 publications

The Multiple and Versatile Roles of Aureobasidium pullulans in the Vitivinicultural Sector

The Multiple and Versatile Roles of Aureobasidium pullulans in the Vitivinicultural Sector

Placebo-Driven Clinical Trials of Transfer Point Glucan #300 in Children With Chronic Respiratory Problems: Iii. Clinical Findings

Inhibition of UVB‐Induced Skin Damage by Exopolymers from Aureobasidium pullulans SM‐2001 in Hairless Mice

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