Effect of β-escin sodium on endothelial cells proliferation, migration and apoptosis

Wang, Xu-Hua; Xu, Bo; Liu, Jingtao; Cui, Jinshi

doi:10.1016/j.vph.2008.07.005

Cited by 38 publications

(36 citation statements)

References 30 publications

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“…24) Wang and his colleagues reported that beta Escin, the major compound of Aesculus hippocastanum seed showed decreased activation of ERK 1/2 and p38 MAPK in human endothelial HUVECs and ECV304 cells. 42) Our study revealed that CK downregulated p38 MAPK in a concentration-dependent manner in bFGF treated HUVECs (Fig. 6C), while activation of p38 MAPK mediates apoptosis in Compound K treated cancer cells.…”

Section: Discussionmentioning

confidence: 54%

Compound K Inhibits Basic Fibroblast Growth Factor-Induced Angiogenesis via Regulation of p38 Mitogen Activated Protein Kinaseand AKT in Human Umbilical Vein Endothelial Cells

Jeong

Lee

Jeong

et al. 2010

Biological & Pharmaceutical Bulletin

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Section: Discussionmentioning

confidence: 54%

Compound K Inhibits Basic Fibroblast Growth Factor-Induced Angiogenesis via Regulation of p38 Mitogen Activated Protein Kinaseand AKT in Human Umbilical Vein Endothelial Cells

Jeong

Lee

Jeong

et al. 2010

Biological & Pharmaceutical Bulletin

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“…TSP-1 is an endogenous inhibitor and its antiangiogenic ability was related to the capability of interacting with FGF-2, thus preventing interaction between FGF-2 and the soluble heparin or endothelial cells heparin sulfate proteoglycans [79], thereby avoiding the progression of the angiogenic process. Angiostatin and endostatin were subsequently identified and both participate in antiangiogenic processes.…”

Section: Other Intracellular Angiogenic Modulatorsmentioning

confidence: 99%

Antiangiogenic compounds: well-established drugs versus emerging natural molecules

et al. 2018

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a b s t r a c tAngiogenesis is the natural and physiologic process of growing blood vessels from pre-existing ones. Pathological angiogenesis occurs when the precise balance of all the molecular pathways that regulate angiogenesis is disrupted, and this process is a critical step in many diseases, including cancer. A limited number of antiangiogenic synthetic drugs have been developed. However, due to toxicity and side effects issues, the search for alternative to existing drugs is ongoing. In this sense, natural molecules obtained from plants or macrofungi, have demonstrated extraordinary potential in the treatment of angiogenesisrelated pathologies, specially taking into consideration its absence or very low toxicity, when compared to synthetic drugs. Using natural compounds as potential angiogenesis modulators is thus a promising field of research, supporting the creation of novel therapies able to reduce the use of drugs and associated side effects. In this review, the current status of antiangiogenic drugs and the wide variety of natural extracts and molecules with antiangiogenic capacities, as well as the angiogenesis molecular pathways and therapeutic targets, are presented. Finally, the challenges that need to be overcome in order to increase the use of natural compounds for clinical purposes are discussed.

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“…In another study, escin sodium was shown to inhibit endothelial cell migration and motility. The antiangiogenic activity of escin sodium was mediated partly by inhibiting ERK and p38 MAP kinase pathways which are involved in cell proliferation, motility and apoptosis [119]. Futhermore, in vivo b-escin was shown to produce synergistic anti-inflammatory activity with low dose glucocorticoids [120].…”

Section: Escinmentioning

confidence: 99%

Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer

et al. 2012

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a b s t r a c tOver the last two decades, extensive research on plant-based medicinal compounds has revealed exciting and important pharmacological properties and activities of triterpenoids. Fruits, vegetables, cereals, pulses, herbs and medicinal plants are all considered to be biological sources of these triterpenoids, which have attracted great attention especially for their potent anti-inflammatory and anti-cancer activities. Published reports in the past have described the molecular mechanism(s) underlying the various biological activities of triterpenoids which range from inhibition of acute and chronic inflammation, inhibition of tumor cell proliferation, induction of apoptosis, suppression of angiogenesis and metastasis. However systematic analysis of various pharmacological properties of these important classes of compounds has not been done. In this review, we describe in detail the pre-clinical chemopreventive and therapeutic properties of selected triterpenoids that inhibit multiple intracellular signaling molecules and transcription factors involved in the initiation, progression and promotion of various cancers. Molecular targets modulated by these triterpenoids comprise, cytokines, chemokines, reactive oxygen intermediates, oncogenes, inflammatory enzymes such as COX-2, 5-LOX and MMPs, anti-apoptotic proteins, transcription factors such as NF-jB, STAT3, AP-1, CREB, and Nrf2 (nuclear factor erythroid 2-related factor) that regulate tumor cell proliferation, transformation, survival, invasion, angiogenesis, metastasis, chemoresistance and radioresistance. Finally, this review also analyzes the potential role of novel synthetic triterpenoids identified recently which mimic natural triterpenoids in physical and chemical properties and are moving rapidly from bench to bedside research.

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Effect of β-escin sodium on endothelial cells proliferation, migration and apoptosis

Cited by 38 publications

References 30 publications

Compound K Inhibits Basic Fibroblast Growth Factor-Induced Angiogenesis via Regulation of p38 Mitogen Activated Protein Kinaseand AKT in Human Umbilical Vein Endothelial Cells

Compound K Inhibits Basic Fibroblast Growth Factor-Induced Angiogenesis via Regulation of p38 Mitogen Activated Protein Kinaseand AKT in Human Umbilical Vein Endothelial Cells

Antiangiogenic compounds: well-established drugs versus emerging natural molecules

Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer

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