“…A reduction in calf blood flow at maximum vasodilatation is observed during chronic beta-adrenoceptor blockade both in hypertensive patients with intermittent claudication (Ingram et al, Smith & Warren, 1982) and in patients with hypertension only (Trap-Jensen et al, 1975;Lepantalo & Totterman, 1983). The flow reduction during chronic beta-adrenoceptor blockade is the probably cause of exacerbation of intermittent claudication in the few patients reported in the literature (Conway, 1975;Rodger et af., 1976;Zacharias, 1976;Vale & Jefferys, 1978;Fogoros, 1980).…”