Walking capacity of patients with intermittent claudication during chronic antihypertensive treatment with metoprolol and methyldopa

Lepäntalo, Mauri; Knorring, Johan von

doi:10.1111/j.1475-097x.1984.tb00803.x

Cited by 13 publications

(2 citation statements)

References 19 publications

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“…RenalfunctoL stodiesshowed,aglome-ardiltrationrteof 19 ml/min 15 days after ingestion aad 12 ml/mm four mohal.ater effectve renal plasma flow rising firm 169 to 480 ml/min. The fila fion rose from 0 11 to 021.…”

Section: Case Reportmentioning

confidence: 96%

Assessment of non-mydriatic fundus photography in detection of diabetic retinopathy.

Williams¹,

Nussey²,

Humphry³

et al. 1986

BMJ

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Non-mydriatic retinal photography with later interpretation of the photographs was assessed as a screening method for the detection of diabetic retinopathy; when compared with an ophthalmologist's clinical assessment in a random group of 62 diabetic patients it was accurate (false negative 6-8%, false positive 2%) and sensitive (sensitivity 96%, specificity 98%). The assessment of further management required based on analysis of the photographs was 96-5% in agreement with the further management suggested by the ophthalmologist after direct clinical assessment ofthe patient.If this technique were used to screen patients in a typical diabetic clinic the predicted positive accuracy rate would be 84% and the predicted negative accuracy rate 99 5%.

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Section: Case Reportmentioning

confidence: 96%

Assessment of non-mydriatic fundus photography in detection of diabetic retinopathy.

Williams¹,

Nussey²,

Humphry³

et al. 1986

BMJ

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show abstract

“…Moreover, the studies included in this review were performed in Finland, 12,13) Denmark, 14,15) Belgium, 16,17) Israel, 18) and the USA. 16,19) Investigation of racial diŠerences and a-receptor sensitivity in patients with IC is necessary.…”

Section: Discussionmentioning

confidence: 99%

β-Adrenergic Blocking Agents and Intermittent Claudication: Systematic Review

2004

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To clarify contradictions in past reports and the package inserts for b-adrenergic blocking agents ( b-blockers) for patients with intermittent claudication (IC), we investigated the eŠects of b-blockers in patients with IC using the systematic review technique. Data sources were randomized, controlled trials that investigated the eŠects of b-blockers compared with the placebo or untreated group (controls) in patients with IC. Primary endpoints were walking distance and walking time, and secondary endpoints were ankle-brachial index (ABI) and calf blood ‰ow. Nine trials were included in the analysis. Meta-analysis showed that there was a signiˆcant worsening in maximal walking distance and initial claudication distance in patients receiving b-blockers, with standardized mean diŠerences of -0.31 and -0.39 (95 ％ conˆdence interval -0.58 to -0.04 and -0.73 to -0.06, P＝0.03 and 0.02, respectively) compared with controls. There were no signiˆcant diŠerences in maximal walking time (0.07, -0.24 to 0.37), time to onset of claudication (0.12, -0.23 to 0.47), ABI at rest (0.24, -0.30 to 0.78), calf blood ‰ow at rest (0.00, -0.26 to 0.25), and calf blood ‰ow after exercise (-0.23, -0.69 to 0.22). However, only one trial evaluated ABI, and the number of cases is increasing, suggesting that b-blockers do not worsen ABI. There was no evidence that b-blockers prescribed for patients with IC have unsuitable``precautions'' in the package inserts. However, reluctance to administer b-blockers to patients because they have IC is not appropriate.

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ß-Adrenergic Blocker Therapy Does Not Worsen Intermittent Claudication in Subjects With Peripheral Arterial Disease

Radack¹

1991

Arch Intern Med

249

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Walking capacity of patients with intermittent claudication during chronic antihypertensive treatment with metoprolol and methyldopa

Cited by 13 publications

References 19 publications

Assessment of non-mydriatic fundus photography in detection of diabetic retinopathy.

Assessment of non-mydriatic fundus photography in detection of diabetic retinopathy.

β-Adrenergic Blocking Agents and Intermittent Claudication: Systematic Review

ß-Adrenergic Blocker Therapy Does Not Worsen Intermittent Claudication in Subjects With Peripheral Arterial Disease

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