Effect of αlipoic acid and silymarin on bladder outlet obstruction

Yıldırım, Abidin; Başeskioğlu, Barbaros; Temel, Halide Edip; Erkasap, Nilüfer; Yenilmez, A.; Uslu, Sema; Özer, Caner; Özkurt, Mete; Dönmez, Turgut

doi:10.3892/etm.2012.831

Cited by 9 publications

(9 citation statements)

References 24 publications

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“…Similar results regarding the relationship between urine 8-OHdG levels and PBOO have been reported elsewhere [25,37,38,39]. In addition, increased levels of 8-OHdG and MDA in blood samples from PBOO models compared with the control ones have been reported by several investigators [25,39,40,41]. In addition to oxidative stress markers in urine and blood, a decrease in mitochondrial DNA copy number and increase in 8-OHdG content were detected in the bladder tissues of a rabbit PBOO model [39].…”

Section: Changes In Oxidative Biomarkers In Partial Bladder Outletsupporting

confidence: 89%

“…Therefore, information on new and additional treatment strategies for BOO is important. As mentioned above, antioxidants are potential therapeutic agents for LUTS caused by PBOO because induced ROS and free radicals due to cyclic ischemia/reperfusion have been implicated in the pathogenesis of bladder dysfunction [40,54]. Antioxidants comprise endogenous enzymes, metal-binding proteins, and exogenous dietary compounds [31].…”

Section: Treatments Using Antioxidants For Bladder Outlet Obstructionmentioning

confidence: 99%

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A Review of Oxidative Stress and Urinary Dysfunction Caused by Bladder Outlet Obstruction and Treatments Using Antioxidants

et al. 2019

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Urinary dysfunction is a common pathological condition that can significantly decrease the quality of life. Bladder outlet obstruction (BOO) is a major cause of urinary dysfunction, and various lower urinary tract diseases including benign prostatic hyperplasia and urethral stricture disease cause BOO. According to the results of a variety of animal experiments on partial BOO (PBOO), there is a general agreement that ischemic conditions and repeated ischemia/reperfusion of the bladder are closely associated with BOO-induced bladder damage, and that increased oxidative stress by ischemia/reperfusion plays a crucial role in the pathological mechanisms underlying urinary dysfunction. Changes in biomarkers of oxidative stress in PBOO animal models support this association between oxidative stress and urinary dysfunction. Oxidative stress is defined as an imbalance between the production of pro-oxidants, such as free radicals and reactive species, and their elimination through protective mechanisms of antioxidants. Therefore, organizing the knowledge on the state of oxidative stress, changes in biomarkers, and biological roles of antioxidants in systemic and bladder tissues is essential to understand the detailed pathological characteristics of the urinary dysfunction caused by PBOO. Furthermore, information on drugs and supplements that have antioxidant effects is important for defining treatment strategies for urinary dysfunction with PBOO. In this review, we paid special attention to the following three issues; (1) changes in oxidative stress, including its biomarkers, (2) antioxidant status, and (3) previous reports on treatment strategies involving agents with antioxidative activity for urinary dysfunction caused by BOO. In particular, we provide systematic information on the detailed mechanisms underlying the antioxidative effects of agents used to treat PBOO. In addition, we show present research issues and research limitations, as well as suggest possible future antioxidant treatment strategies for patients with PBOO.

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Section: Changes In Oxidative Biomarkers In Partial Bladder Outletsupporting

confidence: 89%

Section: Treatments Using Antioxidants For Bladder Outlet Obstructionmentioning

confidence: 99%

A Review of Oxidative Stress and Urinary Dysfunction Caused by Bladder Outlet Obstruction and Treatments Using Antioxidants

et al. 2019

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“…For instance, smokers are 71 more susceptible to bronchitis. According to one report, 15-20% 72 of smokers with bronchitis have a tendency to develop lung cancer 73 [6]. Similarly, people who have colitis are at high risk of developing 74 colon cancer [7].…”

Section: Introductionmentioning

confidence: 99%

Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols

Gupta

Tyagi

Deshmukh-Taskar

et al. 2014

Archives of Biochemistry and Biophysics

273

172

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“…Since ROS is a pathogenic factor in the dysfunctional bladder, antioxidants may be effective for treating bladder dysfunction secondary to BOO. The administration of antioxidants has been shown beneficial for ameliorating bladder dysfunction in animal obstruction models [ 5 , 6 ]. However, the exact mechanism has not been clarified.…”

Section: Introductionmentioning

confidence: 99%

Sulforaphane Ameliorates Bladder Dysfunction through Activation of the Nrf2‐ARE Pathway in a Rat Model of Partial Bladder Outlet Obstruction

Liu

et al. 2016

Oxidative Medicine and Cellular Longevity

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Purpose. We evaluated the effect of sulforaphane (SFN) treatment on the function and changes of expression of Nrf2-ARE pathway in the bladder of rats with bladder outlet obstruction (BOO). Materials and Methods. A total of 18 male Sprague-Dawley rats at age of 8 weeks were divided into 3 groups (6 of each): the sham operated group, the BOO group, and the BOO+SFN group. We examined histological alterations and the changes of oxidative stress markers and the protein expression of the Nrf2-ARE pathway. Results. We found that SFN treatment could prolong micturition interval and increase bladder capacity and bladder compliance. However, the peak voiding pressure was lower than BOO group. SFN treatment can ameliorate the increase of collagen fibers induced by obstruction. SFN treatment also increased the activity of SOD, GSH-Px, and CAT compared to the other groups. The level of bladder cell apoptosis was decreased in BOO rats with SFN treatment. Moreover, SFN could reduce the ratio of Bax/Bcl-2 expression. Furthermore, SFN could activate the Nrf2 expression with elevation of its target antioxidant proteins. Conclusions. The sulforaphane-mediated decrease of oxidative stress and activation of the Nrf2-ARE pathway may ameliorate bladder dysfunction caused by bladder outlet obstruction.

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Effect of αlipoic acid and silymarin on bladder outlet obstruction

Cited by 9 publications

References 24 publications

A Review of Oxidative Stress and Urinary Dysfunction Caused by Bladder Outlet Obstruction and Treatments Using Antioxidants

A Review of Oxidative Stress and Urinary Dysfunction Caused by Bladder Outlet Obstruction and Treatments Using Antioxidants

Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols

Sulforaphane Ameliorates Bladder Dysfunction through Activation of the Nrf2‐ARE Pathway in a Rat Model of Partial Bladder Outlet Obstruction

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