Effect of α1-adrenoceptor antagonists, prazosin and urapidil, on a finger skin vasoconstrictor response to cold stimulation

Harada, Kenji; Fujimura, Akio; Kumagai, Yuko; Ebihara, Akio; Ohashi, Kyoichi

doi:10.1007/bf00203780

Cited by 4 publications

(5 citation statements)

References 10 publications

(13 reference statements)

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“…Additionally, ␤-〈R agonists inhibited TNF-␣ release from mast cells (72) and are potent inhibitors of the IgE-mediated release of tryptase mediators from human mast cells in vitro (834). ␣-and ␤-〈Rs may also regulate important vascular responses in the skin such as vasoconstriction (215,319).…”

Section: Adrenergic Receptorsmentioning

confidence: 99%

Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ

Roosterman¹,

Goerge

Schneider

et al. 2006

Physiological Reviews

536

521

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This review focuses on the role of the peripheral nervous system in cutaneous biology and disease. During the last few years, a modern concept of an interactive network between cutaneous nerves, the neuroendocrine axis, and the immune system has been established. We learned that neurocutaneous interactions influence a variety of physiological and pathophysiological functions, including cell growth, immunity, inflammation, pruritus, and wound healing. This interaction is mediated by primary afferent as well as autonomic nerves, which release neuromediators and activate specific receptors on many target cells in the skin. A dense network of sensory nerves releases neuropeptides, thereby modulating inflammation, cell growth, and the immune responses in the skin. Neurotrophic factors, in addition to regulating nerve growth, participate in many properties of skin function. The skin expresses a variety of neurohormone receptors coupled to heterotrimeric G proteins that are tightly involved in skin homeostasis and inflammation. This neurohormone-receptor interaction is modulated by endopeptidases, which are able to terminate neuropeptide-induced inflammatory or immune responses. Neuronal proteinase-activated receptors or transient receptor potential ion channels are recently described receptors that may have been important in regulating neurogenic inflammation, pain, and pruritus. Together, a close multidirectional interaction between neuromediators, high-affinity receptors, and regulatory proteases is critically involved to maintain tissue integrity and regulate inflammatory responses in the skin. A deeper understanding of cutaneous neuroimmunoendocrinology may help to develop new strategies for the treatment of several skin diseases.

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Section: Adrenergic Receptorsmentioning

confidence: 99%

Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ

Roosterman¹,

Goerge

Schneider

et al. 2006

Physiological Reviews

536

521

View full text Add to dashboard Cite

show abstract

“…As expected, α- and β receptors are also expressed in dermal blood vessels. Their activation by catecholamines causes vasoconstriction and decreases vascular permeability (Ding et al, 1995, Harada et al, 1996). …”

Section: Biogenic Amines In the Skinmentioning

confidence: 99%

Introduction

Słomiński

Żmijewski

Skobowiat

et al. 2012

Sensing the Environment: Regulation of Local and Global Homeostasis by the Skin's Neuroendocrine System

419

136

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“…We demonstrated that 1-adrenoceptor antagonists, which could induce orthostatic hypotension, suppress the finger skin vasoconstrictor response and the degree of the suppression is correlated with the drug plasma concentration. 8 Second, the venoconstrictor response to noradrenaline was examined using LVDT. The dorsal hand vein technique provides a sensitive, easy and reproducible means of assessing the effect of drugs on peripheral veins.…”

Section: Discussionmentioning

confidence: 99%

“…First, the finger-tip vasoconstrictor response to cold stimulation on the contralateral hand was examined using a laser Doppler flowmeter, which is an appropriate means for the study of the vasomotor response mediated by -adrenoceptor stimulation. 7,8 Second, the venoconstrictor response to locally infused noradrenaline was examined using a linear variable differential transformer (LVDT), which provides a sensitive and easy reproducible means of assessing the effect of a drug on peripheral veins. 9 As the decrease in venous blood return to the heart is involved in the pathogenesis of orthostatic hypotension, 3 it is interesting to also examine the effect of these drugs on veins.…”

mentioning

confidence: 99%

Effect of Amezinium Metilsulfate on the Finger Skin Vasoconstrictor Response to Cold Stimulation and Venoconstrictor Response to Noradrenaline

et al. 1998

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hen a person assumes an upright posture, an increase of sympathetic outflow and an inhibition of parasympathetic activity occur reflexly, 1,2 which increases the heart rate and vascular resistance in order to maintain systemic blood pressure. Orthostatic hypotension may be caused by failure of these responses, 3,4 and for the treatment it is important to select a drug considering its pharmacological properties and the pathophysiology of the disease. At present, vasoconsticting agents are often used for the treatment of orthostatic hypotension. To understand the mechanism of these drugs, their effects not only on systemic blood pressure but also on the vasoconstrictor response to sympathetic stimulation should be examined. However, to our knowledge, such information is limited.Amezinium metilsulfate (amezinium) is one of the most popular drugs in Japan for the treatment of orthostatic hypotension. Amezinium has a unique mechanism of vasoconstriction; that is, it inhibits monoamine oxidase (MAO) activity and uptake of noradrenaline, 5,6 which prompted us to examine whether it influences the vasoconstrictor response to sympathetic stimulation and to -adrenoceptor stimulation by noradrenaline in humans.To examine the effects of the drug, the following 2 methods were thought to be suitable and were used in the present study, because they are sensitive and noninvasive and are used for the evaluation of autonomic disturbances or orthostatic hypotension. First, the finger-tip vasoconstrictor response to cold stimulation on the contralateral hand was examined using a laser Doppler flowmeter, which is an appropriate means for the study of the vasomotor response mediated by -adrenoceptor stimulation. 7,8 Second, the venoconstrictor response to locally infused noradrenaline was examined using a linear variable differential transformer (LVDT), which provides a sensitive and easy reproducible means of assessing the effect of a drug on peripheral veins. 9 As the decrease in venous blood return to the heart is involved in the pathogenesis of orthostatic hypotension, 3 it is interesting to also examine the effect of these drugs on veins.In the present study, we examined, using these methods, the effects of amezinium on the vasoconstrictor responses, and compared them in healthy subjects with those of midodrine hydrochloride (midodrine), an 1-adrenoceptor agonist, 10 which is also a popular drug for orthostatic hypotention. Methods SubjectsEight healthy Japanese males (21-26 years, 64-78 kg) were selected. They were normotensive and nonsmokers, without concomitant medication for at least 2 weeks before the study. The study was approved by the Ethical Committee of Jichi Medical School and all subjects gave their informed consent.Jpn Circ J 1998; 62: 824 -828 (Received April 10, 1998; revised manuscript received July 9, 1998; accepted July 14, 1998 Orthostatic hypotension can be caused by an inadequate vasoconstrictor response. The effects of amezinium on vasoconstrictor response to sympathetic stimulation and to exogenous noradre...

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Effect of α1-adrenoceptor antagonists, prazosin and urapidil, on a finger skin vasoconstrictor response to cold stimulation

Abstract: These findings suggest that the cold stimulation response of finger skin vasoconstriction may be used to evaluate the relative alpha 1-adrenoceptor blocking potency of drugs.

Cited by 4 publications

References 10 publications

Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ

Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ

Introduction

Effect of Amezinium Metilsulfate on the Finger Skin Vasoconstrictor Response to Cold Stimulation and Venoconstrictor Response to Noradrenaline

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