Effect of α-helical-CRF[9-41] on feeding in goldfish: Involvement of cortisol and catecholamines.

Pedro, Nuria de; Alonso-Gómez, A.L.; Gancedo, B.; Valenciano, Ana I.; Delgado, M.J.; Alonso‐Bedate, M.

doi:10.1037/0735-7044.111.2.398

Cited by 62 publications

(39 citation statements)

References 25 publications

(52 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…injections observed in this study and their reversal by α-helical CRH (9–41) coinjection concur with the earlier reports of De Pedro et al [22, 25]and together suggest that CRH may be involved in the regulation of food intake in goldfish. Overall, the dose-dependent decrease in goldfish food intake recorded in this study with doses of r/hCRH ranging from 2 to 200 ng/g BW (approximately 0.1–10 µg) is similar to the effects that r/hCRH i.c.v.…”

Section: Discussionsupporting

confidence: 82%

“…Interestingly, although peripheral administration of CRH does not affect food intake in either goldfish or rats [1, 22, 25], peripheral injection of UI decreases food intake in the latter [15]. Similarly, although peripheral injection of CRH can decrease food intake in mice, this effect is much weaker than that induced by urocortin [40].…”

Section: Discussionmentioning

confidence: 99%

“…As in mammals, the anorectic effects of CRH in goldfish appear to be independent of the activation of the hypothalamic-pituitary-interrenal (HPI) axis and centrally mediated [25]. To our knowledge, however, although originally identified in lower chordates [26, 27], the anorectic properties of either UI or sauvagine have yet to be investigated in their species of origin.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Appetite-Suppressing Effects of Urotensin I and Corticotropin-Releasing Hormone in Goldfish <i>(Carassius auratus)</i>

Bernier

Peter²

2001

Neuroendocrinology

107

View full text Add to dashboard Cite

Fish urotensin I (UI), a member of the corticotropin-releasing hormone (CRH) family of peptides, is a potent inhibitor of food intake in mammals, yet the role of UI in the control of food intake in fish is not known. Therefore, to determine the acute effects of UI on appetite relative to those of CRH, goldfish were given intracerebroventricular (i.c.v.) injections of carp/goldfish UI and rat/human CRH (0.2–200 ng/g) and food intake was assessed for a 2-hour period after the injection. UI and CRH both suppressed food intake in a dose-related manner and UI (ED₅₀ = 3.8 ng/g) was significantly more potent than CRH (ED₅₀ = 43.1 ng/g). Pretreatment with the CRH receptor antagonist, α-helical CRH_(9–41), reversed the reduction in food intake induced by i.c.v. UI and CRH. To assess whether endogenous UI and CRH modulate fish appetite, goldfish were given intraperitoneal implants of the glucocorticoid receptor antagonist, RU-486 (50 and 100 µg/g), or the cortisol synthesis inhibitor, metyrapone (100 and 200 µg/g), and food intake was monitored over the following 72 h. Fish treated with either RU-486 or metyrapone were characterized by a sustained and dose-dependent reduction in food intake. Pretreatment with i.c.v. implants of α-helical CRH_(9–41) partially reversed the appetite-suppressing effects of RU-486 and metyrapone. In a parallel experiment, the effects of RU-486 (100 µg/g) and metyrapone (200 µg/g) intraperitoneal implants on brain UI and CRH gene expression were assessed. Relative to sham-implanted controls, fish treated with RU-486 or metyrapone had elevated UI mRNA levels in the hypothalamus and CRH mRNA levels in the telencephalon-preoptic brain region. Together, these results suggest that UI is a potent anorectic peptide in the brain of goldfish and that endogenous CRH-related peptides can play a physiological role in the control of fish appetite.

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Appetite-Suppressing Effects of Urotensin I and Corticotropin-Releasing Hormone in Goldfish <i>(Carassius auratus)</i>

Bernier

Peter²

2001

Neuroendocrinology

107

View full text Add to dashboard Cite

show abstract

“…CRH and UI (a peptide found in the urophysis of teleost fish and structurally related to CRH; [81]) were already shown to be potent inhibitors of food intake in mammals [89]. This anorectic effect can be reversed by pretreatment with the CRH receptor antagonist, α-helical CRH (9–41) [88, 90]. …”

Section: Regulators Of Gh Involved In Energy Balancementioning

confidence: 99%

Comparative Aspects of GH and Metabolic Regulation in Lower Vertebrates

Rousseau

Dufour

2007

Neuroendocrinology

View full text Add to dashboard Cite

In all vertebrates, the regulations of growth and energy balance are complex phenomena which involve elaborate interactions between the brain and peripheral signals. Most vertebrates adopt and maintain a life style after birth, but lower vertebrates may have complex life histories involving metamorphoses, migrations and long periods of fasting. In order to achieve the complex developmental programs associated with these changes, coordinated regulation of all aspects of energy metabolism is required. Somatotropic axis (somatostatin (SRIH) growth hormone (GH) and insulin-like growth factor 1 (IGF1), is known to be involved in the regulation of growth and energy balance. Interestingly, recent studies showed that additional factors such as pituitary adenylate cyclase-activated polypeptide (PACAP), corticotropin-releasing hormone (CRH), ghrelin and leptin could also have major roles in the control of growth and metabolism in lower vertebrates (fish, amphibians and reptiles). This mini-review will survey the function of GH and metabolic regulation in lower vertebrates.

show abstract

“…injections of CRH and UI dose-dependently suppress food intake, with UI being more potent then CRH (De Pedro et al, 1993;Bernier et al, 2001). These effects can be reversed by pre-treatment with the CRH-R antagonist (α-helical CRH 9-41 ) (De Pedro et al, 1997;Bernier et al, 2001). These results indicate that the CRH system is involved in the regulation of food intake in fish.…”

Section: Crhmentioning

confidence: 99%

Peptides and proteins regulating food intake: a comparative view

Gorissen¹,

Flik²,

Huising³

2006

Animal Biol

View full text Add to dashboard Cite

Energy homeostasis is under multiple endocrine and neural control that involves both central and peripheral hormones and neuropeptides. Disorders of energy balance (e.g. obesitas and anorexia nervosa) are caused by subtle dysregulations of these regulatory mechanisms. The hypothalamic arcuate nucleus is a main site of central regulation, where two distinct subpopulations of neurons co-express either neuropeptide Y (NPY) and agouti related protein (AgRP) or proopiomelanocortin (POMC) and cocaine and amphetamine regulated transcript (CART); the former set of peptides increase food intake, the latter decrease food intake and obviously affect energy metabolism. Key peripheral hormones affecting energy metabolism include cholecystokinin (CCK), leptin and insulin which decrease food intake and ghrelin that increases food intake. CCK and ghrelin regulate food intake on the short term (by affecting meal size), whereas leptin and insulin regulate food intake over longer periods spanning several meals. These signals and their physiology are reasonably well-understood in mammals. On the other hand, knowledge on energy metabolism in earlier vertebrates is scant. Recently characterized central food intake regulatory mechanisms in fish suggest that they operate in a manner similar to their mammalian counterparts. Peripheral mechanisms have been poorly studied outside mammals.The recent identification of leptin in several fish species provides new insights and opportunities to enhance our understanding of the regulation of food intake. Comparative analysis of these peripheral mechanisms may shed new light on the function and evolution of the mechanisms at the basis of energy homeostasis. In this review, we summarize the recent developments in understanding of the mechanisms and signals that regulate energy balance in mammals, and compare these to what we now know about their orthologues in earlier vertebrates, with a particular focus on bony fishes.

show abstract

Effect of α-helical-CRF[9-41] on feeding in goldfish: Involvement of cortisol and catecholamines.

Cited by 62 publications

References 25 publications

Appetite-Suppressing Effects of Urotensin I and Corticotropin-Releasing Hormone in Goldfish <i>(Carassius auratus)</i>

Appetite-Suppressing Effects of Urotensin I and Corticotropin-Releasing Hormone in Goldfish <i>(Carassius auratus)</i>

Comparative Aspects of GH and Metabolic Regulation in Lower Vertebrates

Peptides and proteins regulating food intake: a comparative view

Contact Info

Product

Resources

About