Effect of ZnO addition on bioactive CaO–SiO2–P2O5–CaF2 glass–ceramics containing apatite and wollastonite

Kamitakahara, Masanobu; Ohtsuki, Chikara; Inada, Hirofumi; Tanihara, Masao; Miyazaki, Toshiki

doi:10.1016/j.actbio.2006.03.001

Cited by 65 publications

(54 citation statements)

References 12 publications

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“…In addition, it is also possible that Co 2+ may charge balance the orthophosphate (PO 4 ) 3-units in the glass. 31 P MAS-NMR could also be influenced by the presence of Co 2+ in the phosphate phase of the BG. Therefore, in order to further elucidate the role(s) of Co 2+ in the glass structure, 29 Si and 31 P MAS-NMR were performed ( Fig.…”

Section: Effect Of Co 2+ Addition On the Bg Structure And Dissolutionmentioning

confidence: 99%

“…8a). 31 P MAS-NMR spectra suggested that the phosphate phase of the BG was not affected by the addition of Zn 2+ . In contrast, the phosphate peak shifted to a more positive region of the spectra upon Mg 2+ addition to the BG (Fig.…”

mentioning

confidence: 99%

“…Since one of the proposed applications for the hypoxia stimulating BG is in cartilage tissue engineering, zinc and magnesium ions were added to one of the BG compositions in order to decrease HCA formation [30][31][32] , which would be undesirable for soft tissue applications. These two ions have previously been used in TE for a number of different purposes, including as dopants in the production of hydroxycarbonated apatite ceramics 32 , incorporation into polymeric microspheres 33 and also doping in bioactive glasses 22,24,[34][35] .…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and characterization of hypoxia-mimicking bioactive glasses for skeletal regeneration

et al. 2010

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The cellular response to hypoxia is vital for skeletal tissue development and regeneration. Numerous processes, including progenitor cell recruitment, proliferation and differentiation, are activated through the hypoxia pathway in a low oxygen pressure environment. Novel materials-based strategies designed to activate the hypoxia pathway are therefore of great interest for orthopaedic tissue engineering.Here resorbable bioactive glasses (BG) were designed to activate the hypoxia pathway by substitution of Co 2+ for Ca 2+ in the BG and substitution of Co 2+ and Ca 2+ /+2Na + for Si 4+ . This allowed for the controlled release of cobalt, whilst controlling BG bioactivity (apatite-forming ability). Two series of soda-lime-phosphosilicate glasses were manufactured with increasing concentrations of cobalt. Compositions were calculated to maintain constant network connectivity (2.13) by considering cobalt as an intermediate oxide in the first series, and as a network modifier in the second series. Mg 2+ and Zn 2+ were added to one of the Co 2+ -containing glasses to inhibit HCA formation since delay or inhibition of HCA formation is essential for the use of BG in soft tissues, as is the case of cartilage.Cobalt was present in both the silicate and phosphate phases of the BG. In addition, evidence was found for it playing a dual role in the silicate phase, acting as both an intermediate oxide and taking part in the network as well as being a network modifying oxide. Consistent with an intermediate oxide role, the presence of cobalt in the BG was shown to decrease ion release. HCA formation was delayed with cobalt additions. Mg 2+ and Zn 2+ further delayed HCA formation.Cobalt release was found to be proportional to cobalt content of the BGs enabling the controlled delivery of cobalt in therapeutic active doses.

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Section: Effect Of Co 2+ Addition On the Bg Structure And Dissolutionmentioning

confidence: 99%

mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthesis and characterization of hypoxia-mimicking bioactive glasses for skeletal regeneration

et al. 2010

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“…There are numerous studies regarding the development and evaluation of zinc-containing calcium phosphate ceramics both in vitro and in vivo (9)(10)(11)(12)(13) . There are also reports concerning the use of different bioactive glass compositions as short-or longterm zinc delivery vehicles (14)(15)(16)(17) . Bioactive glass, due to its osteostimulative and bone bonding properties, has been successfully used clinically in dental, craniomaxillofacial and spinal applications during the last few decades.…”

Section: +mentioning

confidence: 99%

Preparation and Characterization of Zinc-substituted Bioactive Glasses with Sol–gel Method

2015

Egypt. J. Biophys. Biomed. Engng.

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N PRESENT study, Different bioactive glass samples are prepared based on the following general formula: [65%SiO 2 -(25-X) %CaO-10% P 2 O 5 -X%ZnO)]; Ca 2+ is gradually substituted with Zn 2+(percentages of X= 0, 2, 4, 6, 8 and 10 mol %) by a quick alkalimediated sol-gel method. Development of a calcium phosphate (CP) layer on their surfaces is studied by soaking them in a simulated body fluid (SBF) for different periods. The consequent formation of the CP layer is studied by means of appropriate techniques such as X-ray diffractometry (XRD), Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM) with an energy dispersive system (EDXS). The concentration of Ca 2+, P 5+ ions released from the samples into the SBF is measured by using UV-Vis Spectrophotometer and biochemical Kits. The results show that the formation of calcium phosphate layer on glass surfaces is inhibited by ZnO substitution, and strongly dependent on Zn 2+ concentration.Since the discovery of the first bioglass by Hench et al.. several other glass compositions have been imposed to improve the rehabilitation process in surgical applications. One of the important trends in recent studies is incorporation of some ions in the bioglass composition to improve its biofunctionallity. Regarding the stimulatory effects of some cations such as Mg 2+ , Sr 2+ and Zn 2+ on bone formation either by oral administration or local delivering process (2) , the effect of incorporation of these ions on the physical and physicochemical properties of sol-gel derived glasses has been reported. Zinc (Zn) is the second most prevalent trace element in the human body and is reported to stimulate fracture healing of bone (3) , reduces postmenopausal bone loss (4) , improves bone mineralization (5) , and improves skeletal strength (6) . Furthermore, Zn is an effective agent in killing bacterial strains commonly associated with infection in orthopedic surgeries (7) .Despite the numerous works reporting the stimulating effects of zinc, there are also studies that show other effects of zinc ions on bone cells. Popp et al. studied the effect of Zn 2+ -supplemented osteogenic medium on osteoblastic I

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“…An increase in concentration of ZnO in glass and glass-ceramic system causes decline in apatite forming ability. The amount of ZnO to a base system, which may lower the bioactivity level, was defined as 5 % by S. M. Salman et al [3] while M. Kamitakahara et al [11] reported more than 0.7 % ZnO and A.K. Srivastava and R. Pyare 2012 findings suggested that more than 1 % ZnO content to base system lowered the bioactivity level.…”

Section: Introductionmentioning

confidence: 99%

In vitro evaluation of bioactivity of SiO2-CaO-P2O5-Na2O-CaF2-ZnO glass-ceramics

Riaz

Zia

Saleemi

et al. 2014

Materials Science-Poland

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Zinc is an essential trace element that stimulates bone formation but it is also known as an inhibitor of apatite crystal growth. In this work addition of ZnO to SiO 2 -CaO-P 2 O 5 -Na 2 O-CaF 2 glass-ceramic system was made by conventional meltquenching technique. DSC curves showed that the addition of ZnO moved the endothermic and exothermic peaks to lower temperatures. X-ray diffraction analysis did not reveal any additional phase caused by ZnO addition and showed the presence of wollastonite and hydroxyapatite crystalline phases only in all the glass-ceramic samples. As bio-implant apatite forming ability is an essential condition, the surface reactivity of the prepared glass-ceramic specimens was studied in vitro in Kokubo's simulated body fluid (SBF) [1] with ion concentration nearly equal to human blood plasma for 30 days at 37°C under static condition. Atomic absorption spectroscopy (AAS) was used to study the changes in element concentrations in soaking solutions and XRD, FT-IR and SEM were used to elucidate surface properties of prepared glass-ceramics, which confirmed the formation of HCAp on the surface of all glass-ceramics. It was found that the addition of ZnO had a positive effect on bioactivity of glassceramics and made it a potential candidate for restoration of damaged bones.

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Effect of ZnO addition on bioactive CaO–SiO2–P2O5–CaF2 glass–ceramics containing apatite and wollastonite

Cited by 65 publications

References 12 publications

Synthesis and characterization of hypoxia-mimicking bioactive glasses for skeletal regeneration

Synthesis and characterization of hypoxia-mimicking bioactive glasses for skeletal regeneration

Preparation and Characterization of Zinc-substituted Bioactive Glasses with Sol–gel Method

In vitro evaluation of bioactivity of SiO2-CaO-P2O5-Na2O-CaF2-ZnO glass-ceramics

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