Effect of Zinc Supplementation on Renal Anemia in 5/6-Nephrectomized Rats and a Comparison with Treatment with Recombinant Human Erythropoietin

Feng, Hui-Lin; Chen, Yen‐Hua; Jeng, Sen‐Shyong

doi:10.3390/ijms20204985

Cited by 11 publications

(9 citation statements)

References 29 publications

(44 reference statements)

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“…Feng studied 5/6-nephrectomized rats that became uremic and anemic at 25 days post-surgery, and found Zn stimulated EPO production in the medium, and that the level of EPO produced depended on the concentration of Zn supplementation. Production of erythropoietin through Zn supplementation involves the process of erythropoiesis ( 68 ).…”

Section: Discussionmentioning

confidence: 99%

Benefits and risks of essential trace elements in chronic kidney disease: a narrative review

Xie¹,

Liu²,

Zhang³

et al. 2022

Ann Transl Med

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Background and Objective: Chronic kidney disease (CKD) is an important public health concern.With the decline of renal function, CKD patients gradually progress to end-stage kidney disease and need to undergo dialysis or kidney transplantation to maintain life, bringing a heavy economic burden to the family and society. Therefore, it is necessary to effectively prevent and delay the progression of CKD. Essential trace elements play an indispensable role in CKD, and the objective of this study is to systematically review their benefits in the disease and summarize the risks of their excess.Methods: The keywords "trace elements", "chronic kidney disease", "dialysis", "inflammation", and "fibrosis" and their combinations were used to search for relevant literature published in the PubMed database and Web of Science. We then summarized the role of trace element abnormalities in CKD patients in anemia, oxidative stress, inflammation, and chronic fibrosis, and the risk of their excess.

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Section: Discussionmentioning

confidence: 99%

Benefits and risks of essential trace elements in chronic kidney disease: a narrative review

Xie¹,

Liu²,

Zhang³

et al. 2022

Ann Transl Med

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“…Konomi et al (2005) indicate that hematopoiesis is influenced by zinc level, where it has direct effect in the synthesis of EPO, as well as for the expansion of erythrocytic compartment (Huber & Cousins, 1993). In previous studies, zinc supplementation stimulate erythropoiesis (Feng et al, 2019) and red blood cell formation in the bone marrow in rats (Chen et al, 2018). In this study, the inclusion of pharmacological levels of zinc might increase the total percentage of hematocrits, and with this an increment in the concentration of hemoglobin.…”

Section: Otro Año En Referenciasmentioning

confidence: 61%

Zinc oxide supplementation as a substitute to antibiotics in pigs (Sus scrofa domestica)

Barría,

Mudarra,

Guerra

2024

Agron. Mesoam.

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Introduction. There is a high human concern about resistance to antibiotics due to their inappropriate use as growth promoters in animal husbandry. Objective. To evaluate the effect of a high level of zinc as a substitute to antibiotics in nursery pigs. Material and methods. The study was carried out from June to August 2022 in the province of Chiriqui, Panama. The experimental period consisted of three phases with 14 days each. The nursery pigs (n= 54) were distributed to one of three treatments with six replicates per treatment and three pigs per replicate. The treatments were: 1) control diet, which was formulated to meet the nutritional requirements for nursery pigs; 2) similar to treatment 1, plus 200 mg of amoxicillin /kg of feed and 40 mg of florfenicol /kg of feed during phase 1 (P1) and phase 2 (P2), respectively; and 3) similar to treatment 1, plus 2000 ppm and 1600 ppm of zinc during P1 and P2, respectively. In phase 3 (P3), all pigs were fed a common diet. Results. The supplementation of zinc improved the average daily gain in all phases. Pigs fed zinc diet had better F:G ratio in P2 compared to pigs fed antibiotic diet (p<0.05). A higher concentration of hemoglobin and percentage of monocytes was found in pigs fed with higher level of zinc than the other treatments. (p<0.05). Furthermore, Pigs fed the antibiotic, or the control diet had a lower percentage of fecal dry matter compared to those supplemented with zinc. (p<0.05). Conclusion. The supplementation of high levels of zinc exerted improvements, in comparison to the antibiotic, in terms of hemoglobin concentration, incidence of diarrhea and weight gain in pigs during 42 days after weaning.

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“…Meanwhile, basic experimental studies con rmed that zinc supplementation is closely related to the mitigation of renal complications. The results revealed that zinc relieved anemia in 5/6-nephrectomized rats that became uremic and anemic as it induced erythropoiesis similar to rHuEPO [25]. Also, zinc supplementation strongly blunted vascular calci cation and aortic osteoinduction, and therefore, it might be capable of ameliorating cardiovascular morbidity and mortality by reducing the burden of vascular calci cation in CKD [26].…”

Section: Discussionmentioning

confidence: 99%

Mapping Knowledge Structure and Themes Trends of Trace elements and Chronic Kidney Disease: A Bibliometric Analysis

Yang

Zhang

Lin

et al. 2022

Preprint

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Objective: This study aimed at providing an overview of the current state and the emerging role of trace elements in chronic kidney disease (CKD) using a bibliometric approach. Methods: Scientific literature on CKD published between Jan 2000 to Nov 2021 was identified and retrieved from Web of Science (WoS) databases. Bibliometric analysis and visualization, including annual outputs, core journals, keywords, co-authorship, citation, and co-cited analysis were carried out using software like R, VOSviewer, Citespace, Scimago, and Pajek. Correlation analysis using quantitative and qualitative indicators, such as publication and citation counts, H-index, and journal citation reports was carried out using R and Microsoft Excel. Results: A total of 2551 articles published mainly in the USA, China, and Japan were identified. The University of São Paulo was found to be the most prolific institution, Liu Y the most influential author, and Biological Trace Element Research was the most high-yield journal in this field of research. The top 5 trace elements of interest were divided into two groups; beneficial essential elements including zinc and selenium, and environmental toxicants including copper, cadmium, and aluminum. The top 5 researched keywords were found to be “chronic kidney disease”, “oxidative stress”, “zinc”, “copper”, and “hemodialysis”. Conclusions: This study conducted a comprehensive bibliometric analysis to summarize the trends and structure of trace elements and CKD. Areas like clusters of nutritional status, outcomes of nephropathy, influences of environmental toxicity, and the metabolism of trace elements have been observed to get increasing attention from researchers.

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Effect of Zinc Supplementation on Renal Anemia in 5/6-Nephrectomized Rats and a Comparison with Treatment with Recombinant Human Erythropoietin

Cited by 11 publications

References 29 publications

Benefits and risks of essential trace elements in chronic kidney disease: a narrative review

Benefits and risks of essential trace elements in chronic kidney disease: a narrative review

Zinc oxide supplementation as a substitute to antibiotics in pigs (Sus scrofa domestica)

Mapping Knowledge Structure and Themes Trends of Trace elements and Chronic Kidney Disease: A Bibliometric Analysis

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