Effect of Zinc Supplementation on Physical and Psychological Symptoms, Biomarkers of Inflammation, Oxidative Stress, and Brain-Derived Neurotrophic Factor in Young Women with Premenstrual Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial

Jafari, Fatemeh; Amani, Reza; Tarrahi, Mohammad Javad

doi:10.1007/s12011-019-01757-9

Cited by 54 publications

(49 citation statements)

References 46 publications

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“…There was found that long-term zinc deficiency can lead to reduced zinc concentration in the hippocampus [46]. This induces disturbance in the glucocorticoid's production, which may be reflected in some neuropsychological symptoms common in PMS such as irritability, emotional instability, or depression [46,47].…”

Section: Discussionmentioning

confidence: 99%

Is Premenstrual Syndrome Associated with Inflammation, Oxidative Stress and Antioxidant Status? A Systematic Review of Case–Control and Cross-Sectional Studies

Granda¹,

Szmidt²,

Kałuża³

2021

Antioxidants

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Premenstrual syndrome (PMS) is a cyclically occurring combination of various symptoms, leading to decreased life quality among approximately 30% of women of childbearing age. PMS etiology remains unknown; however, there are some suggestions that inappropriate inflammatory response and oxidative stress are involved. This study aimed to systematically review case–control and cross-sectional studies investigating inflammation markers, oxidative stress, and antioxidant status among women with PMS and controls. The study protocol was registered with PROSPERO (no. CRD42020178545), and the authors followed the guidelines for performing a systemic review recommended by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). By searching PubMed and Scopus databases (up to 8 January 2021), six case–control studies and five cross-sectional studies of medium or high quality were classified to the review. The systematic review included 652 women with PMS and 678 controls, for whom 36 eligible markers were determined. Limited evidence indicates increased levels of inflammatory parameters and suggests decreased antioxidant status in PMS women. Insufficient data with inconsistent results made it impossible to formulate a firm conclusion on the contribution of oxidative stress in PMS occurrence. To acknowledge the role of inflammation, oxidative stress, and antioxidant status in the pathophysiology of PMS, further research with case–control design and large study groups is needed.

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Section: Discussionmentioning

confidence: 99%

Is Premenstrual Syndrome Associated with Inflammation, Oxidative Stress and Antioxidant Status? A Systematic Review of Case–Control and Cross-Sectional Studies

Granda¹,

Szmidt²,

Kałuża³

2021

Antioxidants

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“…In a double-blind, placebo-controlled trial of zinc supplementation for premenstrual syndrome, sixty women (18–30 years) were randomly assigned to receive either 30 mg of zinc gluconate and/or placebo for 12 weeks. The zinc-administered group showed beneficial effects on physical and psychological symptoms of premenstrual syndrome, total antioxidant capacity, and brain-derived neurotrophic factor [ 126 ].…”

Section: Role Of Antioxidants In the Brainmentioning

confidence: 99%

Neuroprotective Effect of Antioxidants in the Brain

Lee

Cha

2020

IJMS

250

154

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The brain is vulnerable to excessive oxidative insults because of its abundant lipid content, high energy requirements, and weak antioxidant capacity. Reactive oxygen species (ROS) increase susceptibility to neuronal damage and functional deficits, via oxidative changes in the brain in neurodegenerative diseases. Overabundance and abnormal levels of ROS and/or overload of metals are regulated by cellular defense mechanisms, intracellular signaling, and physiological functions of antioxidants in the brain. Single and/or complex antioxidant compounds targeting oxidative stress, redox metals, and neuronal cell death have been evaluated in multiple preclinical and clinical trials as a complementary therapeutic strategy for combating oxidative stress associated with neurodegenerative diseases. Herein, we present a general analysis and overview of various antioxidants and suggest potential courses of antioxidant treatments for the neuroprotection of the brain from oxidative injury. This review focuses on enzymatic and non-enzymatic antioxidant mechanisms in the brain and examines the relative advantages and methodological concerns when assessing antioxidant compounds for the treatment of neurodegenerative disorders.

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“…37 Also, results of the Jafari et al study revealed that zinc supplementation for 12 weeks among women with the premenstrual syndrome had a positive effect on physical and psychological symptoms of premenstrual syndrome. 38 Previous studies have shown that oxidative stress was increased in chronic fatigue syndrome; since zinc has antioxidant properties, people with fatigue should use certain types of antioxidants such as zinc supplements. 39 Despite the limitation of our study is the lack of a placebo group, the results of this study added a new perspective to the issue of fatigue among elderly people.…”

Section: Discussionmentioning

confidence: 99%

The effect of zinc supplementation on fatigue among elderly community dwellers: A parallel clinical trial

Afzali

Goli

Moravveji

et al. 2021

Health Science Reports

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Background and Aims: Fatigue is one of the most common complaints of the elderly.This study was conducted to assess the effect of zinc supplements on fatigue among the elderly.Methods: This randomized clinical trial was conducted on 150 elderly aged ≥60 years who were recruited from the health centers (Kashan, Iran) with a convenience sampling method. Participants were allocated to intervention and control groups by block randomization. Participants in the intervention group received a daily dose of 30 mg of zinc supplement for 70 days; meanwhile, in the control group, no intervention was performed. The level of fatigue was measured by the multidimensional fatigue inventory before and after the intervention. Both groups were homogeneous in terms of demographic variables, fatigue, and serum zinc level before the intervention. The significance level was considered as 0.05 in all tests.Results: Zinc supplementation significantly reduced fatigue (mean difference: À10.41 vs 1.37, P < .001) and increased serum zinc level (mean difference: 14.22, vs À0.57, P < .001) compared to the control group. Conclusion:Consumption of zinc supplements for the elderly is recommended to overcome fatigue.

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Effect of Zinc Supplementation on Physical and Psychological Symptoms, Biomarkers of Inflammation, Oxidative Stress, and Brain-Derived Neurotrophic Factor in Young Women with Premenstrual Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial

Cited by 54 publications

References 46 publications

Is Premenstrual Syndrome Associated with Inflammation, Oxidative Stress and Antioxidant Status? A Systematic Review of Case–Control and Cross-Sectional Studies

Is Premenstrual Syndrome Associated with Inflammation, Oxidative Stress and Antioxidant Status? A Systematic Review of Case–Control and Cross-Sectional Studies

Neuroprotective Effect of Antioxidants in the Brain

The effect of zinc supplementation on fatigue among elderly community dwellers: A parallel clinical trial

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