The effect of zinc supplementation on fatigue among elderly community dwellers: A parallel clinical trial

Afzali, Abolfazl; Goli, Shahrbanoo; Moravveji, Alireza; Bagheri, Hossein; Mirhosseini, Seyedmohammad; Ebrahimi, Hossein

doi:10.1002/hsr2.301

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…Serum zinc concentration also diminishes with aging, with about 35% to 45% of the elderly having zinc levels lower than the normal range [70]. Regarding supplementation, in a study conducted on 150 elderly subjects aged ≥60 years, daily administration of 30 mg of zinc for 70 days significantly reduced fatigue and increased serum zinc levels [54]. Moreover, in a randomized, double-blind, placebo-controlled trial, administration of 220 mg of zinc sulphate in women with premenstrual syndrome (PMS) from the 16th day of each menstrual cycle to the 2nd day of the next for 3 months, resulted in significant improvements in fatigue scores as well as other symptoms of PMS monitored using the premenstrual symptoms screening tool [55].…”

Section: Non-clinical Populations 421 Vitamins and Mineralsmentioning

confidence: 99%

Nutrient Therapy for the Improvement of Fatigue Symptoms

Barnish¹,

Sheikh²,

Scholey

2023

Nutrients

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Fatigue, characterised by lack of energy, mental exhaustion and poor muscle endurance which do not recover following a period of rest, is a common characteristic symptom of several conditions and negatively impacts the quality of life of those affected. Fatigue is often a symptom of concern for people suffering from conditions such as fibromyalgia, chronic fatigue syndrome, cancer, and multiple sclerosis. Vitamins and minerals, playing essential roles in a variety of basic metabolic pathways that support fundamental cellular functions, may be important in mitigating physical and mental fatigue. Several studies have examined the potential benefits of nutrients on fatigue in various populations. The current review aimed to gather the existing literature exploring different nutrients’ effects on fatigue. From the searches of the literature conducted in PubMed, Ovid, Web of Science, and Google scholar, 60 articles met the inclusion criteria and were included in the review. Among the included studies, 50 showed significant beneficial effects (p < 0.05) of vitamin and mineral supplementation on fatigue. Altogether, the included studies investigated oral or parenteral administration of nutrients including Coenzyme Q10, L-carnitine, zinc, methionine, nicotinamide adenine dinucleotide (NAD), and vitamins C, D and B. In conclusion, the results of the literature review suggest that these nutrients have potentially significant benefits in reducing fatigue in healthy individuals as well as those with chronic illness, both when taken orally and parenterally. Further studies should explore these novel therapies, both as adjunctive treatments and as sole interventions.

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Section: Non-clinical Populations 421 Vitamins and Mineralsmentioning

confidence: 99%

Nutrient Therapy for the Improvement of Fatigue Symptoms

Barnish¹,

Sheikh²,

Scholey

2023

Nutrients

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“…In contrast, the activity of mitochondrial glutamic dehydrogenase remains unaltered during deficiency, suggesting that zinc deficiency does not affect all proteins equally; more work is needed to understand the role of zinc deficiency and its associated protein function within muscle [82]. Interestingly, in elderly community dwellers, zinc supplementation reduces multidimensional fatigue inventory (MFI) scores [83]. The MFI assesses levels of general, physical, and mental fatigue, as well as physical activity and motivation, based on a five-point Likert-scale-based 20-question test.…”

Section: Crosstalk Between Mineralsmentioning

confidence: 99%

Calcium’s Role and Signaling in Aging Muscle, Cellular Senescence, and Mineral Interactions

Terrell,

Choi,

Choi

2023

IJMS

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Calcium research, since its pivotal discovery in the early 1800s through the heating of limestone, has led to the identification of its multi-functional roles. These include its functions as a reducing agent in chemical processes, structural properties in shells and bones, and significant role in cells relating to this review: cellular signaling. Calcium signaling involves the movement of calcium ions within or between cells, which can affect the electrochemical gradients between intra- and extracellular membranes, ligand binding, enzyme activity, and other mechanisms that determine cell fate. Calcium signaling in muscle, as elucidated by the sliding filament model, plays a significant role in muscle contraction. However, as organisms age, alterations occur within muscle tissue. These changes include sarcopenia, loss of neuromuscular junctions, and changes in mineral concentration, all of which have implications for calcium’s role. Additionally, a field of study that has gained recent attention, cellular senescence, is associated with aging and disturbed calcium homeostasis, and is thought to affect sarcopenia progression. Changes seen in calcium upon aging may also be influenced by its crosstalk with other minerals such as iron and zinc. This review investigates the role of calcium signaling in aging muscle and cellular senescence. We also aim to elucidate the interactions among calcium, iron, and zinc across various cells and conditions, ultimately deepening our understanding of calcium signaling in muscle aging.

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