Effect of Zinc on Hepatic and Renal Tissues of Chronically Arsenic Exposed Rats: A Biochemical and Histopathological Study

Garla, Roobee; Sharma, Nikita; Shamli,; Kaushal, Naveen; Garg, M. L.

doi:10.1007/s12011-020-02549-2

Cited by 17 publications

(9 citation statements)

References 49 publications

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“…Animal studies have found oxidative damage from As, Cd, and Pb [ 31 , 32 , 33 ]. Some studies have proved the interaction between essential metals and toxic metals [ 34 , 35 ]; however, the mechanisms of multiple metal exposure are unclear. Identifying the inflammation of metal mixtures is troublesome due to the independent, antagonistic, or additive interactions between toxic metals and essential elements.…”

Section: Introductionmentioning

confidence: 99%

Use of Generalized Weighted Quantile Sum Regressions of Tumor Necrosis Factor Alpha and Kidney Function to Explore Joint Effects of Multiple Metals in Blood

Luo

Yang³

et al. 2022

IJERPH

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Exposure to heavy metals could lead to adverse health effects by oxidative reactions or inflammation. Some essential elements are known as reactors of anti-inflammatory enzymes or coenzymes. The relationship between tumor necrosis factor alpha (TNF-α) and heavy metal exposures was reported. However, the interaction between toxic metals and essential elements in the inflammatory response remains unclear. This study aimed to explore the association between arsenic (As), cadmium (Cd), lead (Pb), cobalt (Co), copper (Cu), selenium (Se), and zinc (Zn) in blood and TNF-α as well as kidney function. We enrolled 421 workers and measured the levels of these seven metals/metalloids and TNF-α in blood; kidney function was calculated by CKD-EPI equation. We applied weighted quantile sum (WQS) regression and group WQS regression to assess the effects of metal/metalloid mixtures to TNF-α and kidney function. We also approached the relationship between metals/metalloids and TNF-α by generalized additive models (GAM). The relationship of the exposure–response curve between Pb level and TNF-α in serum was found significantly non-linear after adjusting covariates (p < 0.001). Within the multiple-metal model, Pb, As, and Zn were associated with increased TNF-α levels with effects dedicated to the mixture of 50%, 31%, and 15%, respectively. Grouped WQS revealed that the essential metal group showed a significantly negative association with TNF-α and kidney function. The toxic metal group found significantly positive associations with TNF-α, serum creatinine, and WBC but not for eGFR. These results suggested Pb, As, Zn, Se, and mixtures may act on TNF-α even through interactive mechanisms. Our findings offer insights into what primary components of metal mixtures affect inflammation and kidney function during co-exposure to metals; however, the mechanisms still need further research.

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Section: Introductionmentioning

confidence: 99%

Use of Generalized Weighted Quantile Sum Regressions of Tumor Necrosis Factor Alpha and Kidney Function to Explore Joint Effects of Multiple Metals in Blood

Luo

Yang³

et al. 2022

IJERPH

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“…Studi lain dari Gora et al ( 2014) yang melakukan pemberian arsen (sodium arsenit 10 mg/kg, selama 28 hari secara oral) pada tikus Wistar menyebabkan perubahan struktur organ hati berupa degenerasi vakuola, inflamasi, nekrosis sel hepatik yang ditandai dengan inti piknosis dan vakuolisasi sitoplasma. Perubahan organ hati pada tikus Wistar jantan akibat toksisitas arsen dilaporkan juga pada studi Garla et al (2021). Perubahan yang terlihat berupa infiltrasi sel-sel radang di sekitar hepatoportal triad, kerusakan sel-sel hepatosit, perluasan sinusoid karena sel hepatosit yang nekrosis, kerusakan pada vena sentral, vakuolisasi sitoplasma dan karyorrhexis (Gambar 1B).…”

Section: Keracunan Arsen (As)unclassified

“…Normal, tidak ada kelainan pada duktus empedu (BD), arteri hepatik (HA) dan sel hepatosit (H); (B) Hati yang mengalami dilatasi vena sentral (DC), perluasan sinusoid (IS), dan sel hepatosit yang mengalami karyorryorhexis (K). Pewarnaan H&E, perbesaran 400X (Garla et al 2021).…”

Section: Gambar 1 Perbandingan Histologi Hati Tikus Wistar: (A)unclassified

Animals Organs Pathological Changes of Heavy Metals Toxicity

Ahmad¹,

Tiffarent²,

Sugiartanti

et al. 2022

WARTAZOA

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Heavy metal toxicity in livestock animals will affect and damage the body organs. The animals that are exposed to heavy metal residues will suffer pain and experience pathological changes in body organs that support the metabolic function of the body's work. Some organs lead to the specific diagnosis of specific contaminating heavy metals. Examination of pathological changes in the body of animals will help a lot in diagnosing, handling animals that are exposed to certain heavy metal toxicity. The respiratory tract, digestive tract and reproductive tract in animals can direct the detection of the effects of toxicity of certain heavy metal. Organs that experience pathological changes can also to help diagnose contamination due to certain heavy metals. The purpose of this writing is to help adding the knowledge of pathological changes regarding heavy metal toxicity Arsenic (As), Cadmium (Cd), Cooper (Cu), Mercury (Hg), Mangan (Mn) and Lead (Pb), in the organs of animals.

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“…In several other studies with common carp, zinc supplementation also has been shown to be effective in protecting against arsenic-induced toxicity in the heart [ 68 ], kidney [ 69 , 70 ], liver [ 71 ], spleen [ 72 ], and pancreas [ 73 ]. In a rat model of chronic arsenic toxicity, zinc supplementation can protect against damages to the liver and kidney [ 74 ]. In a neuronal cell line, zinc was shown to alleviate arsenic-induced apoptosis ( Figure 6 ) [ 75 ].…”

Section: Management and Control Of Arsenic-induced Neurological Deficitsmentioning

confidence: 99%

Exposure to Environmental Arsenic and Emerging Risk of Alzheimer’s Disease: Perspective Mechanisms, Management Strategy, and Future Directions

Rahman

Hannan

Uddin

et al. 2021

Toxics

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Alzheimer’s disease (AD) is one of the most prevailing neurodegenerative diseases, characterized by memory dysfunction and the presence of hyperphosphorylated tau and amyloid β (Aβ) aggregates in multiple brain regions, including the hippocampus and cortex. The exact etiology of AD has not yet been confirmed. However, epidemiological reports suggest that populations who were exposed to environmental hazards are more likely to develop AD than those who were not. Arsenic (As) is a naturally occurring environmental risk factor abundant in the Earth’s crust, and human exposure to As predominantly occurs through drinking water. Convincing evidence suggests that As causes neurotoxicity and impairs memory and cognition, although the hypothesis and molecular mechanism of As-associated pathobiology in AD are not yet clear. However, exposure to As and its metabolites leads to various pathogenic events such as oxidative stress, inflammation, mitochondrial dysfunctions, ER stress, apoptosis, impaired protein homeostasis, and abnormal calcium signaling. Evidence has indicated that As exposure induces alterations that coincide with most of the biochemical, pathological, and clinical developments of AD. Here, we overview existing literature to gain insights into the plausible mechanisms that underlie As-induced neurotoxicity and the subsequent neurological deficits in AD. Prospective strategies for the prevention and management of arsenic exposure and neurotoxicity have also been discussed.

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Effect of Zinc on Hepatic and Renal Tissues of Chronically Arsenic Exposed Rats: A Biochemical and Histopathological Study

Cited by 17 publications

References 49 publications

Use of Generalized Weighted Quantile Sum Regressions of Tumor Necrosis Factor Alpha and Kidney Function to Explore Joint Effects of Multiple Metals in Blood

Use of Generalized Weighted Quantile Sum Regressions of Tumor Necrosis Factor Alpha and Kidney Function to Explore Joint Effects of Multiple Metals in Blood

Animals Organs Pathological Changes of Heavy Metals Toxicity

Exposure to Environmental Arsenic and Emerging Risk of Alzheimer’s Disease: Perspective Mechanisms, Management Strategy, and Future Directions

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