Effect of Zinc on Cytochrome Oxidase Activity

Duncan, Graeme; Gray, Louise F.; Daniel, Louise J.

doi:10.3181/00379727-83-20439

Cited by 27 publications

(5 citation statements)

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“…According to Sadasivan (1951), zinc toxicity reduced rat liver catalase and cytochrome oxidase and the effect was reversed by copper. Duncan et al (1953) found that 1% zinc in the diet produced anemia in the rat and the effect was reversed by copper. Grant-Frost and Underwood (1958) reported that in rats .5% zinc depressed food intake and therefore body weight.…”

Section: Introductionmentioning

confidence: 97%

Effect of Zinc Toxicity in Laying White Leghorn Pullets and Hens

Palafox

Ho-a

1980

Poultry Science

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Two experiments involving 124 Single Comb White Leghorn (Hy-Line) laying pullets and hens were conducted to determine the effect of zinc toxicity on bird performance. Twenty milligrams of zinc per gram of diet fed for 5 days significantly lowered fertility and hatchability of pullet eggs collected 14 to 28 days after the 5-day zinc feeding period. Zinc significantly depressed body weight on the day 5 of zinc feeding and significantly lowered egg poroduction from 0 to 4 weeks of test. Egg production from 4 to 12 weeks, feed conversion from 0 to 12 weeks, final body weight, and livability were not significantly affected. Hens fed the supplemental zinc for five days had depressed egg production from 0 to 4 weeks. Egg production from 4 to 12 weeks, feed conversion, final body weight, and livability were not significantly affected. Compared to their respective controls, 2% supplemental zinc fed for 5 days significantly improved hen but not pullet egg weight. Hen eggs collected 28 days after hens received the zinc diet contained significantly less potassium, copper, and zinc than the controls.

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Section: Introductionmentioning

confidence: 97%

Effect of Zinc Toxicity in Laying White Leghorn Pullets and Hens

Palafox

Ho-a

1980

Poultry Science

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“…The excretion of copper in milk is increased in zinc-deficient dairy cows (Kirchgessner et al, 1982). When the dietary zinc supply is excessively increased and the copper level is kept constant, copper deficiency is manifested by a reduction of copper concentrations in liver, heart, and serum, and the activities of copper metalloenzymes such as ceruloplasmin and cytochrome oxidase are decreased (Duncan et al, 1953;Van Reen, 1953;Cox and Harris, 1960). The effective dose level varies over a wide range from about 100 to more than 1000 mg Zn/kg dietary dry matter, because various dietary constituents may influence the availability of intestinal zinc and, thereby, the effects on copper metabolism.…”

Section: Zinc and Coppermentioning

confidence: 99%

Interactions of Zinc with Other Micronutrients

Prasad

1993

Biochemistry of Zinc

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“…In zinc deficient dairy cows copper excretion in milk is increased (185). In contrast, excessive dietary zinc in experimental animals produces copper deficiency, as manifested by reduced copper concentrations in liver, heart, and serum, and decreased activities of copper metalloenzymes such as ceruloplasmin, cytochrome oxidase, and superoxide dismutase (186)(187)(188)(189)(190). The effective dose level of zinc varies over a wide range from about 100 to more than 1000 mg/kg dietary dry matter, because various dietary constituents influence the availability of the dietary zinc and, thereby, the effects on copper metabolism.…”

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confidence: 99%

Zinc: health effects and research priorities for the 1990s.

Walsh

Sandstead

Prasad

et al. 1994

Environ Health Perspect

267

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This review critically summarizes the literature on the spectrum of health effects of zinc status, ranging from symptoms of zinc deficiency to excess exposure. Studies on zinc intake are reviewed in relation to optimum requirements as a function of age and sex. Current knowledge on the biochemical properties of zinc which are critical to the essential role of this metal in biological systems is summarized. Dietary and physiological factors influencing the bioavailability and utilization of zinc are considered with special attention to interactions with iron and copper status. The effects of zinc deficiency and toxicity are reviewed with respect to specific organs, immunological and reproductive function, and genotoxicity and carcinogenicity. Finally, key questions are identified where research is needed, such as the risks to human health of altered environmental distribution of zinc, assessment of zinc status in humans, effects of zinc status in relation to other essential metals on immune function, reproduction, neurological function, and the cardiovascular system, and mechanistic studies to further elucidate the biological effects of zinc at the molecular level. - There is considerable evidence that zinc deficiency in humans is a serious worldwide problem and outweighs the potential problem of accidental, self-imposed, or environmental exposure to zinc excess. Acute deficiency (1) and chronic deficiency (2) are well-known entities in human populations and are probably much more common than generally recognized. The importance of zinc for human health was first documented in 1963 (3) Telephone (617) (617) 638-4329. E-mail: ctwalsh~bu.edu renal disease, and other chronically debilitating diseases are now known to be predisposing factors for zinc deficiency in humans (4).Zinc deficiency is reflected in clinical syndromes which affect men and women of all ages and all socioeconomic and cultural classes in the United States. It is neither prevalent in any specific area of the United States nor associated with any specific or definitive biochemical marker, which can make its identification difficult and confusing. Its presence is manifested by a wide spectrum of symptoms, from acute, life threatening problems to mild subclinical or marginal disorders which may only vaguely disturb well being. The acute problems are often seen in profoundly ill patients treated in hospitals, whereas subclinical problems may be so vague that patients seek assistance outside traditional medical practice.Based upon clinical data and using traditional, epidemiologic techniques, Henkin and Aamodt (5) have reclassified zinc deficiency into three syndromes; these are a) acute, b) chronic, and c) subacute zinc deficiency. Acute zinc deficiency is relatively uncommon and follows parenteral hyperalimentation or oral L-histidine administration. Chronic zinc deficiency is more common, usually resulting from chronic dietary lack of zinc. Subacute or latent zinc deficiency is the most common of these syndromes. It is estimated that there are 4...

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Effect of Zinc on Cytochrome Oxidase Activity

Cited by 27 publications

References 1 publication

Effect of Zinc Toxicity in Laying White Leghorn Pullets and Hens

Effect of Zinc Toxicity in Laying White Leghorn Pullets and Hens

Interactions of Zinc with Other Micronutrients

Zinc: health effects and research priorities for the 1990s.

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