Effect of zinc content on structural, functional, morphological, and thermal properties of kappa-carrageenan/NaCMC nanocomposites

Sabbagh, Farzaneh; Kiarostami, K H; Khatir, Nadia Mahmoudi; Rezania, Shahabaldin; Muhamad, Ida Idayu; Hosseini, Fakhrisadat

doi:10.1016/j.polymertesting.2020.106922

Cited by 39 publications

(27 citation statements)

References 52 publications

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“…Figure 2A,B represent the thermographs of the individual polymers and injectable hydrogel. The thermogram of the HA showed 15% weight loss at the temperature range of 50-100 • C, which was associated with the removal of bounded water in the network [42], while the decomposition of the polysaccharide backbone occurred at the temperature range of 250-300 • C, which resulted in 35% weight loss [43]. Similarly, the results from the diffractogram of the HA showed a broad exothermic peak at 100 • C, corresponding to the dehydration of the HA.…”

Section: Thermogravimetric and Differential Scanning Calorimetry Thermographsmentioning

confidence: 89%

Biofunctional Hyaluronic Acid/κ-Carrageenan Injectable Hydrogels for Improved Drug Delivery and Wound Healing

et al. 2022

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The in situ injectable hydrogel system offers a widespread range of biomedical applications in prompt chronic wound treatment and management, as it provides self-healing, maintains a moist wound microenvironment, and offers good antibacterial properties. This study aimed to develop and evaluate biopolymer-based thermoreversible injectable hydrogels for effective wound-healing applications and the controlled drug delivery of meropenem. The injectable hydrogel was developed using the solvent casting method and evaluated for structural changes using proton nuclear magnetic resonance, Fourier transforms infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy. The results indicated the self-assembly of hyaluronic acid and kappa-carrageenan and the thermal stability of the fabricated injectable hydrogel with tunable gelation properties. The viscosity assessment indicated the in-situ gelling ability and injectability of the hydrogels at various temperatures. The fabricated hydrogel was loaded with meropenem, and the drug release from the hydrogel in phosphate buffer saline (PBS) with a pH of 7.4 was 96.12%, and the simulated wound fluid with a pH of 6.8 was observed to be at 94.73% at 24 h, which corresponds to the sustained delivery of meropenem. Antibacterial studies on P. aeruginosa, S. aureus, and E. coli with meropenem-laden hydrogel showed higher zones of inhibition. The in vivo studies in Sprague Dawley (SD) rats presented accelerated healing with the drug-loaded injectable hydrogel, while 90% wound closure with the unloaded injectable hydrogel, 70% in the positive control group (SC drug), and 60% in the negative control group was observed (normal saline) after fourteen days. In vivo wound closure analysis confirmed that the developed polymeric hydrogel has synergistic wound-healing potential.

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Section: Thermogravimetric and Differential Scanning Calorimetry Thermographsmentioning

confidence: 89%

Biofunctional Hyaluronic Acid/κ-Carrageenan Injectable Hydrogels for Improved Drug Delivery and Wound Healing

et al. 2022

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“…Gel matrices are very vulnerable to water, drug molecules, and a variety of hydrophilic small molecules due to the presence of hydrophilic polymer chains [ 81 ]. Hydrogels are composed of elastic as well as viscous components [ 82 , 83 ]. Any hydrogel’s viscous and elastic properties may be fine-tuned by altering the precursors, reaction parameters, and amount of water absorbed.…”

Section: Hydrogelsmentioning

confidence: 99%

Design of Magnetic Hydrogels for Hyperthermia and Drug Delivery

Ganguly

Margel

2021

Polymers

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Hydrogels are spatially organized hydrophilic polymeric systems that exhibit unique features in hydrated conditions. Among the hydrogel family, composite hydrogels are a special class that are defined as filler-containing systems with some tailor-made properties. The composite hydrogel family includes magnetic-nanoparticle-integrated hydrogels. Magnetic hydrogels (MHGs) show magneto-responsiveness, which is observed when they are placed in a magnetic field (static or oscillating). Because of their tunable porosity and internal morphology they can be used in several biomedical applications, especially diffusion-related smart devices. External stimuli may influence physical and chemical changes in these hydrogels, particularly in terms of volume and shape morphing. One of the most significant external stimuli for hydrogels is a magnetic field. This review embraces a brief overview of the fabrication of MHGs and two of their usages in the biomedical area: drug delivery and hyperthermia-based anti-cancer activity. As for the saturation magnetization imposed on composite MHGs, they are easily heated in the presence of an alternating magnetic field and the temperature increment is dependent on the magnetic nanoparticle concentration and exposure time. Herein, we also discuss the mode of different therapies based on non-contact hyperthermia heating.

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“…Finally, as the outer layer of TVS, PCL-Col nanofibers were wrapped on the surface of the hydrogel layer. Findings demonstrate that TVS had superior maximum tensile stress (UTS) [ 311 ], strain to failure (STF), predicted burst strength, and suture retention strength (SRS) when compared to natural blood arteries. Human umbilical vein endothelial cells (HUVECs) were used to test the biocompatibility of TVS, and the results showed that the cells could effectively connect to the graft surface while maintaining high vitality.…”

Section: Applications Of 4d Printed Hydrogelsmentioning

confidence: 99%

Smart and Biomimetic 3D and 4D Printed Composite Hydrogels: Opportunities for Different Biomedical Applications

et al. 2021

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In recent years, smart/stimuli-responsive hydrogels have drawn tremendous attention for their varied applications, mainly in the biomedical field. These hydrogels are derived from different natural and synthetic polymers but are also composite with various organic and nano-organic fillers. The basic functions of smart hydrogels rely on their ability to change behavior; functions include mechanical, swelling, shaping, hydrophilicity, and bioactivity in response to external stimuli such as temperature, pH, magnetic field, electromagnetic radiation, and biological molecules. Depending on the final applications, smart hydrogels can be processed in different geometries and modalities to meet the complicated situations in biological media, namely, injectable hydrogels (following the sol-gel transition), colloidal nano and microgels, and three dimensional (3D) printed gel constructs. In recent decades smart hydrogels have opened a new horizon for scientists to fabricate biomimetic customized biomaterials for tissue engineering, cancer therapy, wound dressing, soft robotic actuators, and controlled release of bioactive substances/drugs. Remarkably, 4D bioprinting, a newly emerged technology/concept, aims to rationally design 3D patterned biological matrices from synthesized hydrogel-based inks with the ability to change structure under stimuli. This technology has enlarged the applicability of engineered smart hydrogels and hydrogel composites in biomedical fields. This paper aims to review stimuli-responsive hydrogels according to the kinds of external changes and t recent applications in biomedical and 4D bioprinting.

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Effect of zinc content on structural, functional, morphological, and thermal properties of kappa-carrageenan/NaCMC nanocomposites

Cited by 39 publications

References 52 publications

Biofunctional Hyaluronic Acid/κ-Carrageenan Injectable Hydrogels for Improved Drug Delivery and Wound Healing

Biofunctional Hyaluronic Acid/κ-Carrageenan Injectable Hydrogels for Improved Drug Delivery and Wound Healing

Design of Magnetic Hydrogels for Hyperthermia and Drug Delivery

Smart and Biomimetic 3D and 4D Printed Composite Hydrogels: Opportunities for Different Biomedical Applications

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