Effect of Yi-nao-jie-yu decoction on &amp;gamma;-aminobutyric acid type A receptor in the hippocampus and serum inflammatory factors in a rat model of poststroke anxiety

Zhang, Wen; Zhao, Ruizhen; Li, Xiaoli; Cui, Xia; Zhao, Zijun; Mao, Yingqiu; Wu, Fengzhi; Tang, Qisheng

doi:10.2147/ndt.s115116

Cited by 4 publications

(5 citation statements)

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“…Our results showed that the value of Glu/GABA and the activity of AchE in hippocampus and cortex did not change in RF group, compared with sham group, which was consistent with the results of MWM. It was reported that GABA in mice brain, plays a key role in the modulation of anxiety response [ 40 , 41 , 42 , 43 ], and in this study, we found that the level of GABA in mice brain decreased significantly after RF exposure. Considering the OFT and EPM results, we speculated that the GABA probably was involved in RF induce anxiety in mice.…”

Section: Discussionsupporting

confidence: 69%

Effects of 1.8 GHz Radiofrequency Fields on the Emotional Behavior and Spatial Memory of Adolescent Mice

Zhang

Guo

et al. 2017

IJERPH

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The increasing use of mobile phones by teenagers has raised concern about the cognitive effects of radiofrequency (RF) fields. In this study, we investigated the effects of 4-week exposure to a 1.8 GHz RF field on the emotional behavior and spatial memory of adolescent male mice. Anxiety-like behavior was evaluated by open field test (OFT) and elevated plus maze (EPM) test, while depression-like behavior was evaluated by sucrose preference test (SPT), tail suspension test (TST) and forced swim test (FST). The spatial learning and memory ability were evaluated by Morris water maze (MWM) experiments. The levels of amino acid neurotransmitters were determined by liquid chromatography-mass spectrometry (LC-MS). The histology of the brain was examined by hematoxylin-eosin (HE) staining. It was found that the depression-like behavior, spatial memory ability and histology of the brain did not change obviously after RF exposure. However, the anxiety-like behavior increased in mice, while, the levels of γ-aminobutyric acid (GABA) and aspartic acid (Asp) in cortex and hippocampus significantly decreased after RF exposure. These data suggested that RF exposure under these conditions do not affect the depression-like behavior, spatial memory and brain histology in adolescent male mice, but it may however increase the level of anxiety, and GABA and Asp were probably involved in this effect.

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Section: Discussionsupporting

confidence: 69%

Effects of 1.8 GHz Radiofrequency Fields on the Emotional Behavior and Spatial Memory of Adolescent Mice

Zhang

Guo

et al. 2017

IJERPH

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“…The rats in the model group were provided water at regular times (9:00 AM to 9:10 AM, and 9:00 PM to 9:10 PM) simultaneously during the 7 days. The rats in the model group were given an empty water bottle stimulation randomly each day during the watering periods to induce the emotional stress for 14 consecutive days, while rats in the control group were allowed to get purified water freely (20). Twenty-one days later, The TS and comorbid anxiety model group was further divided into three groups by evaluating grades of stereotypy (21): the model group (n = 12), the fluoxetine hydrochloride (FLX) group (n = 12), and the JPZDD group (n = 12).…”

Section: Ts and Comorbid Anxiety Modelmentioning

confidence: 99%

“…The elevated plus maze (EPM) test was conducted 1, 2, 4 weeks after oral administration. The rats were tested for EPM as described previously (20,22). The paradigm consisted of a cross-shaped plastic apparatus, elevated 100 cm above the ground, with two opposite open arms (50 × 10 cm 2 ) and two closed arms (50 × 10 cm 2 ) surrounded by a black plastic wall, 15 cm tall.…”

Section: Elevated Plus Mazementioning

confidence: 99%

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Effect of Jian-Pi-Zhi-Dong Decoction on the Amino Acid Neurotransmitters in a Rat Model of Tourette Syndrome and Comorbid Anxiety Disorder

Zhang

Liu

et al. 2020

Front. Psychiatry

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Amino acid neurotransmitters have been shown to correlate with Tourette syndrome (TS) and its comorbidities. In this study, we investigated the effects of Jian-Pi-Zhi-Dong Decoction (JPZDD), a formula containing 10 different Chinese medical herbs, on amino acid neurotransmitters in rats. We established a rat model of Tourette syndrome and comorbid anxiety with an iminodipropionitrile injection plus uncertain empty water bottle stimulation for 3 weeks. Then the rats were randomly divided into four groups: control group and model group were gavaged with saline, while the remaining two treatment groups were gavaged with fluoxetine hydrochloride or JPZDD for four consecutive weeks. We recorded the behaviors of the rats with TS and comorbid anxiety by stereotypy recording, open field test, and elevated plus maze. We observed mitochondrial changes with transmission electron microscopy. We measured the content of glutamate (GLU) and g-aminobutyric acid (GABA) both in the serum and striatum and the expression of their receptors by Western blot and real-time polymerase chain reaction. The study revealed that JPZDD was effective in alleviating the behavioral symptoms of both tic and anxiety in the rat model groups. These results might be associated with the increase in GABA levels and decrease in GLU levels in the serum, as well as an increase in striatal GABA level by the activation of GABA receptors Type A (GABAAR). JPZDD treatment also reversed the mitochondrial dysfunction both in the striatum and cortex in affected animals.

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“…Many traditional Chinese medicine (TCM) prescriptions “nourishing” in the TCM theory system have the effects of improving cognition and emotion ( Nishiyama et al, 1994 ; Itoh et al, 1998 ; Lin et al, 2003 ; Yang et al, 2006 ; Zhang et al, 2016 ; Hu et al, 2020 ; Shang et al, 2020 ). Furthermore, TCM shows good prospects in promoting AHN ( Zhang et al, 2014 ; Sreenivasmurthy et al, 2017 ; Chen et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Active Fraction Combination From Liuwei Dihuang Decoction Improves Adult Hippocampal Neurogenesis and Neurogenic Microenvironment in Cranially Irradiated Mice

et al. 2021

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Background: Cranial radiotherapy is clinically used in the treatment of brain tumours; however, the consequent cognitive and emotional dysfunctions seriously impair the life quality of patients. LW-AFC, an active fraction combination extracted from classical traditional Chinese medicine prescription Liuwei Dihuang decoction, can improve cognitive and emotional dysfunctions in many animal models; however, the protective effect of LW-AFC on cranial irradiation–induced cognitive and emotional dysfunctions has not been reported. Recent studies indicate that impairment of adult hippocampal neurogenesis (AHN) and alterations of the neurogenic microenvironment in the hippocampus constitute critical factors in cognitive and emotional dysfunctions following cranial irradiation. Here, our research further investigated the potential protective effects and mechanisms of LW-AFC on cranial irradiation–induced cognitive and emotional dysfunctions in mice.Methods: LW-AFC (1.6 g/kg) was intragastrically administered to mice for 14 days before cranial irradiation (7 Gy γ-ray). AHN was examined by quantifying the number of proliferative neural stem cells and immature neurons in the dorsal and ventral hippocampus. The contextual fear conditioning test, open field test, and tail suspension test were used to assess cognitive and emotional functions in mice. To detect the change of the neurogenic microenvironment, colorimetry and multiplex bead analysis were performed to measure the level of oxidative stress, neurotrophic and growth factors, and inflammation in the hippocampus.Results: LW-AFC exerted beneficial effects on the contextual fear memory, anxiety behaviour, and depression behaviour in irradiated mice. Moreover, LW-AFC increased the number of proliferative neural stem cells and immature neurons in the dorsal hippocampus, displaying a regional specificity of neurogenic response. For the neurogenic microenvironment, LW-AFC significantly increased the contents of superoxide dismutase, glutathione peroxidase, glutathione, and catalase and decreased the content of malondialdehyde in the hippocampus of irradiated mice, accompanied by the increase in brain-derived neurotrophic factor, insulin-like growth factor-1, and interleukin-4 content. Together, LW-AFC improved cognitive and emotional dysfunctions, promoted AHN preferentially in the dorsal hippocampus, and ameliorated disturbance in the neurogenic microenvironment in irradiated mice.Conclusion: LW-AFC ameliorates cranial irradiation–induced cognitive and emotional dysfunctions, and the underlying mechanisms are mediated by promoting AHN in the dorsal hippocampus and improving the neurogenic microenvironment. LW-AFC might be a promising therapeutic agent to treat cognitive and emotional dysfunctions in patients receiving cranial radiotherapy.

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Effect of Yi-nao-jie-yu decoction on γ-aminobutyric acid type A receptor in the hippocampus and serum inflammatory factors in a rat model of poststroke anxiety

Cited by 4 publications

References 35 publications

Effects of 1.8 GHz Radiofrequency Fields on the Emotional Behavior and Spatial Memory of Adolescent Mice

Effects of 1.8 GHz Radiofrequency Fields on the Emotional Behavior and Spatial Memory of Adolescent Mice

Effect of Jian-Pi-Zhi-Dong Decoction on the Amino Acid Neurotransmitters in a Rat Model of Tourette Syndrome and Comorbid Anxiety Disorder

Active Fraction Combination From Liuwei Dihuang Decoction Improves Adult Hippocampal Neurogenesis and Neurogenic Microenvironment in Cranially Irradiated Mice

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