Effects of 1.8 GHz Radiofrequency Fields on the Emotional Behavior and Spatial Memory of Adolescent Mice

Zhang, Junping; Zhang, Keying; Guo, Ling; Chen, Qi-Liang; Gao, Peng; Li, Jing; Guo, Guozhen; Ding, Gui‐Rong

doi:10.3390/ijerph14111344

Cited by 36 publications

(29 citation statements)

References 34 publications

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“…This result showed that no gross thermal effects were involved (Fig. B), which was published elsewhere [Zhang et al, ]. In addition, the body weight of mice was measured about every 4 days during the 28 days of exposure.…”

Section: Methodssupporting

confidence: 78%

“…The microwave signal source from a horn antenna with an adjustable power of 1–200 W and 40 W was applied in the experiment. A schematic diagram of the experimental setup for RF exposure is presented in Figure A [Zhang et al, ]. The specific absorption rates (SARs) of 17 tissue types were calculated by EFDTD7.2.3 (Remcom, State College, PA) at 1 meter below the horn antenna, including brain, bone, tongue, eyes, esophagus, heart, liver, lung, spleen, stomach, digestive system, kidney, urinary bladder, penis, testis, skin, and muscle.…”

Section: Methodsmentioning

confidence: 99%

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Effects of 1.8 GHz radiofrequency field on microstructure and bone metabolism of femur in mice

Guo

Zhang

et al. 2018

Bioelectromagnetics

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To investigate the effects of 1.8 GHz radiofrequency (RF) field on bone microstructure and metabolism of femur in mice, C57BL/6 mice (male, age 4 weeks) were whole-body exposed or sham exposed to 1.8 GHz RF field. Specific absorption rates of whole body and bone were approximately 2.70 and 1.14 W/kg (6 h/day for 28 days). After exposure, microstructure and morphology of femur were observed by microcomputed tomography (micro-CT), Hematoxylin and Eosin (HE) and Masson staining. Subsequently, bone parameters were calculated directly from the reconstructed images, including structure model index, bone mineral density, trabecular bone volume/total volume, connectivity density, trabecular number, trabecular thickness, and trabecular separation. Biomarkers that reflect bone metabolism, such as serum total alkaline phosphatase (ALP), bone-specific alkaline phosphatase (BALP), and tartrate-resistant acid phosphatase 5b (TRACP-5b), were determined by biochemical assay methods. Micro-CT and histology results showed that there was no significant change in bone microstructure and the above parameters in RF group, compared with sham group. The activity of serum ALP and BALP increased 29.47% and 16.82%, respectively, in RF group, compared with sham group (P < 0.05). In addition, there were no significant differences in the activity of serum TRACP-5b between RF group and sham group. In brief, under present experimental conditions, we did not find support for an effect of 1.8 GHz RF field on bone microstructure; however, it might promote metabolic function of osteoblasts in mice. Bioelectromagnetics. 39:386-393, 2018. © 2018 Wiley Periodicals, Inc.

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Section: Methodssupporting

confidence: 78%

Section: Methodsmentioning

confidence: 99%

Effects of 1.8 GHz radiofrequency field on microstructure and bone metabolism of femur in mice

Guo

Zhang

et al. 2018

Bioelectromagnetics

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“…A mouse was defined as immobility when minimal movements of the front legs instead of the hind legs. Furthermore, small oscillations and pendulum like swings which gained momentum from the earlier mobility were also consider as immobility (Zhang et al, 2017 ).…”

Section: Methodsmentioning

confidence: 99%

Investigation of Behavioral Dysfunctions Induced by Monoamine Depletions in a Mouse Model of Parkinson's Disease

Jiao

et al. 2018

Front. Cell. Neurosci.

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Parkinson's disease (PD) is characterized not only by typical motor symptoms, but also by nonmotor symptoms in the early stages. In addition to the loss of dopaminergic (DAergic) neurons, progressive degenerations of noradrenergic (NA) and serotonergic (5-HT) neurons were also observed. However, the respective effects and interactions of these monoamine depletions on certain nonmotor symptoms are still largely unknown. In the present study, we performed selective depletions of NA, 5-HT and DA in mice by intraperitioneal injection of N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (DSP-4), 4-chloro-L-phenylalanine (pCPA) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), respectively. DSP-4 led to a 34% decrease in the number of NAergic neurons in the locus coeruleus, and MPTP led to a 30% decrease in the number of DAergic neurons in the substantia nigra. Although there was no obvious change in the number of 5-HTergic neurons in the dorsal raphe nucleus after pCPA treatment, the levels of 5-HT and its metabolite in the frontal cortex and hippocampus were reduced, respectively. Locomotor activity deficit was induced by DA depletion and a decrease in traveled distance was potentiated by additional NA depletion. Despair-associated depressive-like behavior could be observed in every group. Anxiety states emerged only from the combined depletion of two or three monoamines. However, combined depletion of the three monoamines dramatically induced anhedonia, and it could also aggravate the depressive-like and anxiety behavior. Furthermore, NA depletion significantly reduced spatial learning and memory ability, which was not enhanced by additional 5-HT or DA depletion. Our data highlighted the interactive role of NA, 5-HT and DA in the motor, emotional and cognitive deficits, providing new insight into the complex orchestration of impaired monoaminergic systems that related to the pathology of PD.

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“…Zhang et al [55] reported that exposure of juvenile mice to 1800 MHz had no effect on spatial learning or memory as assessed in a Morris water maze. Animals were exposed for 6 h each day for 28 days at a whole-body SAR of 2.7 W/kg (2.2 W/kg in the brain).…”

Section: Resultsmentioning

confidence: 99%

Can Low-Level Exposure to Radiofrequency Fields Effect Cognitive Behaviour in Laboratory Animals? A Systematic Review of the Literature Related to Spatial Learning and Place Memory

Sienkiewicz

Rongen

2019

IJERPH

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This review considers whether exposure to low-level radiofrequency (RF) fields, mostly associated with mobile phone technology, can influence cognitive behaviour of laboratory animals. Studies were nominated for inclusion using an a priori defined protocol with preselected criteria, and studies were excluded from analysis if they did not include sufficient details about the exposure, dosimetry or experimental protocol, or if they lacked a sham-exposed group. Overall, 62 studies were identified that have investigated the effects of RF fields on spatial memory and place learning and have been published since 1993. Of these, 17 studies were excluded, 20 studies reported no significant field-related effects, 21 studies reported significant impairments or deficits, and four studies reported beneficial consequences. The data do not suggest whether these outcomes are related to specific differences in exposure or testing conditions, or simply represent chance. However, some studies have suggested possible molecular mechanisms for the observed effects, but none of these has been substantiated through independent replication. Further behavioural studies could prove useful to resolve this situation, and it is suggested that these studies should use a consistent animal model with standardized exposure and testing protocols, and with detailed dosimetry provided by heterogeneous, anatomically-realistic animal models.

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Effects of 1.8 GHz Radiofrequency Fields on the Emotional Behavior and Spatial Memory of Adolescent Mice

Cited by 36 publications

References 34 publications

Effects of 1.8 GHz radiofrequency field on microstructure and bone metabolism of femur in mice

Effects of 1.8 GHz radiofrequency field on microstructure and bone metabolism of femur in mice

Investigation of Behavioral Dysfunctions Induced by Monoamine Depletions in a Mouse Model of Parkinson's Disease

Can Low-Level Exposure to Radiofrequency Fields Effect Cognitive Behaviour in Laboratory Animals? A Systematic Review of the Literature Related to Spatial Learning and Place Memory

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