Effect of X-Rays on the Incorporation of Carbon-14 into Desoxyribonucleic Acid

Hevesy, G.

doi:10.1038/163869c0

Cited by 47 publications

(7 citation statements)

References 2 publications

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“…The 14C activity ofourrat-liver histones after administration of glycine was higher than that of thymus; with lysine little difference was detectable. Amino acid uptake into the liver nuclear fractions was if anything slightly increased, as has been reported for acetate incorporation into liver protein by Hevesy (1949a) and for phenylalanine into a number of liver-protein fractions by Butler, Cohn & Crathom (1956). Glycine incorporation into DNA was unaffected although 32p uptake was reduced.…”

Section: Resultssupporting

confidence: 70%

“…Protein synthesis as well as deoxyribonucleic acid synthesis, in thymus nuclei seems to be inhibited by radiation. The latter finding has been reported earlier (Hevesy, 1949a), as has the inhibition of 32p phosphate uptake into nuclear ribonucleic acid (RNA) (Ord & Stocken, 1956b). Even though fractions isolated from thymus nuclei, in addition to histone, exhibited a depression in amino acid incorporation after irradiation, the possibility of these ill-defined proteins being mixtures of denatured histones has not been eliminated.…”

Section: Discussion 638+63supporting

confidence: 60%

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The effect of X-radiation in vivo on protein and nucleoprotein metabolism in the rat

Richmond

Ord

Stocken

1957

Biochemical Journal

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Section: Resultssupporting

confidence: 70%

Section: Discussion 638+63supporting

confidence: 60%

The effect of X-radiation in vivo on protein and nucleoprotein metabolism in the rat

Richmond

Ord

Stocken

1957

Biochemical Journal

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“…There are many reports in the literature which state that nucleic acid synthesis is inhibited by radiations. Thus, ionizing radiation inhibits nucleic acid synthesis without affecting protein synthesis (Hevesy, 1949; see also Abrams, 1951). Since ionizing radiations are not strictly comparable to exciting radiations such as ultraviolet, the experiments of the Lwoff group on the induction of lysis and virus maturation in lysogenic bacteria by ultraviolet irradiation (Lwoff et al, 1950;) may be more pertinent to this discussion.…”

Section: Discussionmentioning

confidence: 99%

Growth, Respiration, and Nucleic Acid Synthesis in Ultraviolet-Irradiated and in Photoreactivated Escherichia Coli

Kelner

1953

J Bacteriol

186

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Irradiation of the cell with wavelengths (circa 2,600 A) of ultraviolet light strongly absorbed by nucleic acids can result in profound cellular changes, e.g., inhibition of growth, or of adaptive enzyme formation; in increased mutation or in death. Visible and near-visible light (from about 3,600 to 4,900 A), henceforth referred to as reactivating light, when applied to the cell after ultraviolet irradiation, will prevent death of the cell (a phenomenon called photoreactivation, Kelner, 1949a, 1949b, 1951) or reduce the frequency of induced mutants among survivors (Kelner, 1949b; Novick and Szilard, 1949; Newcombe and Whitehead, 1951; Kimball and Gaither, 1951; Brown, 1951); reduce ultravioletinduced inhibition of growth (Blum et al., 1950; Blum and Matthews, 1952; Wells and Giese, 1950); prevent the inhibition of adaptive enzyme formation (Swenson and Giese, 1950); prevent injury to cells of higher plants (Bawden and Kleezkowski, 1952); prevent changes in the morphology of the nucleoli in grasshopper neuroblats (Carlson and McMaster, 1951). The multiplicity of the biological effects of ultraviolet radiation, and the fact that most of them are reversed by reactivating light, suggests the theory that ultraviolet causes some basic change in the cell, which in turn causes the various other biological effects, usually after some delay. Reactivating light, by reversing this basic change, prevents the other effects (mutation, death, inhibition of adaptive enzyme formation, etc.). Even if this theory is not correct, it would be helpful to find some ultraviolet-induced reaction which is affected by reactivating light, and 1 Aided in part by a grant from the American Cancer Society. 2 This work was done during the tenure of a

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“…Hevesy et al (8,13,14) have reported that a decrease in the rate of incorporation *of carbon-14 derived from labeled sodium acetate to the purines of ribonucleic and deoxyribonucleic acids after total-bofly irradiation of young mice. At the same time there was an enhanced incorporation of carbon-14 into the total proteins of kidneys, intestinal mucosa, liver, and muscle.…”

Section: Discussionmentioning

confidence: 97%

Changes in Respiratory Gases of Burros after Prolonged Fractionated Total-Body γ-Irradiation

Lane¹,

Wilding²,

Rust³

et al. 1955

Radiation Research

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Effect of X-Rays on the Incorporation of Carbon-14 into Desoxyribonucleic Acid

Cited by 47 publications

References 2 publications

The effect of X-radiation in vivo on protein and nucleoprotein metabolism in the rat

The effect of X-radiation in vivo on protein and nucleoprotein metabolism in the rat

Growth, Respiration, and Nucleic Acid Synthesis in Ultraviolet-Irradiated and in Photoreactivated Escherichia Coli

Changes in Respiratory Gases of Burros after Prolonged Fractionated Total-Body γ-Irradiation

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