Effect of Wound Fluid on Cultured Keratinocytes

Soehnchen, R; Hilbert, E.; Zouboulis, Ch.C.; Orfanos, Constantin E.

doi:10.1007/978-3-642-77882-7_32

Cited by 1 publication

(2 citation statements)

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“…It is accepted that an occlusive or semi‐occlusive wound dressing produces a moist wound environment 20 –22 . In vitro studies (cell cultures) demonstrated that the addition of wound fluid induced an enhancement of cell proliferation 23 . An improvement of the cellular and biochemical processes of wound healing was reported 24 –26 .…”

Section: Discussionmentioning

confidence: 99%

“…20±22 In vitro studies (cell cultures) demonstrated that the addition of wound ¯uid induced an enhancement of cell proliferation. 23 An improvement of the cellular and biochemical processes of wound healing was reported. 24±26 Occlusion causes a moist microenvironment with an enrichment of growth factors such as interleukin-1, tumour necrosis factor and transforming growth factor b in the wound ¯uid.…”

Section: Discussionmentioning

confidence: 99%

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Improvement and retardation of wound healing: effects of pharmacological agents in laboratory animal studies

Kietzmann

1999

Veterinary Dermatology

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Impaired wound healing is an important problem; retardation of healing may be induced by endogenous and/or exogenous factors and treatments capable of ameliorating these eects are needed. The eects of solutions containing light ichthyol or povidone iodine, of ointments containing zinc oxide (ZO) and/ or cod liver oil (CLO), and of a polyurethane-hydrogel foam wound dressing were examined on healing of full-thickness murine skin wounds impaired by systemic dexamethasone. The eects of the ointments were also studied on murine skin ulceration induced by subcutaneous sodium dodecyl sulphate solution. Light ichthyol at 1% and 2% but not at 5% and 10%, povidone iodine at 1% and the foam accelerated impaired healing. The ointments containing ZO or CLO accelerated healing of impaired full-thickness wounds and of ulcerated skin; ZO and CLO were synergistic. These studies demonstrate the value of murine models in the evaluation of agents employed in veterinary wound dressings.

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