Effect of western and high fat diets on memory and cholinergic measures in the rat

Kosari, Sam; Badoer, Emilio; Nguyen, Jason; Killcross, Simon; Jenkins, Trisha A.

doi:10.1016/j.bbr.2012.07.017

Cited by 82 publications

(56 citation statements)

References 56 publications

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“…On the other hand, Kosari and colleagues found that Long-Evans rats fed a WSD or high-fat diet experienced impaired spatial memory on the Y-maze task, but showed no deficits on the NOR task [54]. It is important to note that the Kosari et al study used adult rats, unlike the previously discussed studies, which utilized juvenile animals.…”

Section: Discussionmentioning

confidence: 94%

Western-style diet induces insulin insensitivity and hyperactivity in adolescent male rats

Marwitz

Woodie

Blythe

2015

Physiology & Behavior

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Section: Discussionmentioning

confidence: 94%

Western-style diet induces insulin insensitivity and hyperactivity in adolescent male rats

Marwitz

Woodie

Blythe

2015

Physiology & Behavior

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“…Long-term use of high fat diet or high energy diet could induce obesity and affect serum lipid levels and oxidative stress, which in turn affect learning and memory functions [37,38,39]. The traditional Mediterranean-style diet has fewer meats and carbohydrates and more plant-based foods and monounsaturated fat than a typical American diet.…”

Section: Discussionmentioning

confidence: 99%

Effects of Walnut Polyphenol on Learning and Memory Functions in Hypercholesterolemia Mice

Shi¹,

Chen²,

Zhao³

et al. 2014

JFNR

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Evidence suggests that dietary walnuts are able to induce improvements in memory and learning functions. In addition, polyphenols have been shown to modulate critical neuronal signalling pathways involved in processes of learning and memory. The aim of our present work was to study the effect of polyphenol extracts from walnut testa (42%) on learning and memory functions in hypercholesterolemia mice based on obesity, hypercholesterolemia and oxidative stress. At the beginning of the experiment, mice were divided into 3 groups, one of them served as normol control group (NCG), the second as hypercholesterolemia control group (HCG), the last as walnut polyphenol-treated group (WTG). After 8 weeks of treatment, we investigated the performance of C57BL/6J mice in Morris water maze test. The results showed that the escape latency was significant increase in HCG, when compared to NCG and WTG. In addition, the number of crossings was significant decrease in HCG, when compared to NCG and WTG (-47.35% and -43.35%, respectively, P < 0.01). The swimming distance was longer in HCG than NCG and WTG [F (2,96) = 44.45, P < 0.001]. However, there was no significant difference in swimming speed among NCG, HCG and WTG [F (2, 96) = 0.167, P > 0.05]. On the other hand, walnut polyphenol (WP) significantly decreased serum total triglycerides, cholesterol and malondialdehyde (MDA) level (-36.31%, -31.48% and -21.51%, respectively, P < 0.01) and increased superoxide dismutase (SOD) activity (+48.39%, P < 0.01). Administration of WP significantly decreased MDA level (-36.86%, P < 0.01) and increased SOD activity (+17.08%, P < 0.01) in brain tissues. In conclusion, walnut polyphenol was able to improve learning and memory functions.

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“…In one study of short-term exposure to 60% HF diet, juvenile C57BL/6 mice were found to have decreased spontaneous alternations after only 1 week on the HF diet, despite no differences in body weight [67]. In another long-term study, adult Long–Evans rats were found to have impairment in preference for the novel arm of a Y-Maze after 12 weeks of exposure to either a ‘Western diet’ or 60% HF diet despite the fact that only those rats consuming the ‘Western diet’ were heavier than controls [68]. A second study using a 21.2% HF diet in adult male mice did find increased body weight and impaired preference for the novel arm of a Y-Maze after 10 weeks on the diet [69].…”

Section: Behavioral Phenotypesmentioning

confidence: 99%

“…In rats, impairment has been found in male Sprague–Dawley rats fed a ‘HF, high sucrose’ diet for 8 weeks [27], or treated with 60% HF diet + streptozotocin in a model of diabetes [83]. Alternatively, no Novel Object Recognition deficits were found in male Long–Evans rats after consuming either a ‘Western diet’ or a 60% HF diet [68]. …”

Section: Behavioral Phenotypesmentioning

confidence: 99%

Effects of high-fat diet exposure on learning & memory

Cordner

Tamashiro

2015

Physiology & Behavior

214

151

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The associations between consumption of a high-fat or ‘Western’ diet and metabolic disorders such as obesity, diabetes, and cardiovascular disease have long been recognized and a great deal of evidence now suggests that diets high in fat can also have a profound impact on the brain, behavior, and cognition. Here, we will review the techniques most often used to assess learning and memory in rodent models and discuss findings from studies assessing the cognitive effects of high-fat diet consumption. The review will then consider potential underlying mechanisms in the brain and conclude by reviewing emerging literature suggesting that maternal consumption of a high-fat diet may have effects on the learning and memory of offspring.

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Effect of western and high fat diets on memory and cholinergic measures in the rat

Cited by 82 publications

References 56 publications

Western-style diet induces insulin insensitivity and hyperactivity in adolescent male rats

Western-style diet induces insulin insensitivity and hyperactivity in adolescent male rats

Effects of Walnut Polyphenol on Learning and Memory Functions in Hypercholesterolemia Mice

Effects of high-fat diet exposure on learning & memory

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