Effect of Walnut on Lipid Profile in Obese Female in Different Ethnic Groups of Quetta, Pakistan

Mushtaq, Rehana; Mushtaq, Rubina; Khan, Zahida Tasawar

doi:10.3923/pjn.2009.1617.1622

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Ros et al and Zhao et al have shown that diets counting the LA and the ALA such as walnuts significantly lower total cholesterol, LDL, and TG [12]. Furthermore the study of Lavedrine et al has shown that serum HDLc and apo A1 rise by walnut.…”

Section: Lipid Profilementioning

confidence: 95%

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Effects of Walnut on Lipid Profile as Well as the Expression of Sterol-Regulatory Element Binding Protein-1c(SREBP-1c) and Peroxisome Proliferator Activated Receptors α (PPARα) in Diabetic Rat

Oshaghi¹,

Sorkhani²,

Rezaei³

2012

FNS

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Diabetes Mellitus has appeared as a universal burden. Studies have reported that mortality from Coronary Heart Disease (CHD) in diabetic patients is 2 -4 times higher than nondiabetics. In this respect, walnut is a treatment which has beneficial effects on CHD risk factors. PPARα and SREBP-1c play an important role in the regulation of lipid metabolism. This study was aimed to evaluate the effects of walnut on lipid profile as well as SREBP-1c and PPARα protein levels in rats. Animals were randomly divided into 3 groups (n = 6); Group 1: Received chow only (control), Group 2: Diabetic rats + chow, Group 3: Diabetic rats + chow supplemented with 4% of whole walnuts. After four weeks rats were sacrificed, blood was collected; lipid profiles as well as SREBP-1c and PPARα protein levels were determined. Compared with diabetic rats walnut significantly decreased serum cholesterol (P < 0.01), LDL-c (P < 0.01), triglyceride (P < 0.001) and VLDL-c (P < 0.001) and also increased HDL-c (P < 0.05) compared with diabetic. Moreover, SREBP-1c protein level significantly decreased (P < 0.05) and PPARα significantly increased in walnut group compared with diabetic group (P < 0.05). The findings showed that walnut administration in diet clinically decreases atherosclerosis risk factors. Lipid profile reduction might be due to the rise of PPARα and the reduction of SREBP-1c by this medical treatment in liver.

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Section: Lipid Profilementioning

confidence: 95%

“…Furthermore the study of Lavedrine et al has shown that serum HDLc and apo A1 rise by walnut. Many studies demonstrate that there are negative correlations between HDL-c and cardiovascular morbidity [12,13].…”

Section: Lipid Profilementioning

confidence: 99%

Effects of Walnut on Lipid Profile as Well as the Expression of Sterol-Regulatory Element Binding Protein-1c(SREBP-1c) and Peroxisome Proliferator Activated Receptors α (PPARα) in Diabetic Rat

Oshaghi¹,

Sorkhani²,

Rezaei³

2012

FNS

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Effect of Locally Manufactured Niger Seed Oil on Lipid Profile Compared to Imported Palm and Sunflower Oils on Rat Models

2018

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Background Different types of dietary lipids have been shown to affect lipid metabolism and lipid profile differently. Objective This study aims to assess the effect of local niger seed oil on serum lipid profile compared to palm oil and sunflower oil in rats. Methods The effect of the 15% plant oils on serum lipid profile, body weight gain percentage, and feed efficiency ratio was assessed after 8 weeks of experimental period. Results and Conclusion The 15% niger seed oil showed decrease and increase in the level of lipid profile as compared to rats fed with 15% palm oil and sunflower oil (except Triacylglycerol), respectively. The 15% niger seed oil showed significant decrease and increase in body weight gain percentage as compared to the 15% palm oil and 15% sunflower oil, respectively. The feed efficiency ratio was significantly higher and lower in the 15% niger seed oil compared to rats fed with 15% sunflower oil and control group and the palm oil fed rats, respectively. The current study concluded that consumption of locally manufactured niger seed oil decreased the blood lipid profiles, body weight gain percentage, and feed efficiency ratio as compared to palm oil. Utilization of oils containing more unsaturated fatty acids like niger seed oil is recommended to reduce the risk of developing cardiovascular disease.

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Walnut Prevents Cognitive Impairment by Regulating the Synaptic and Mitochondrial Dysfunction via JNK Signaling and Apoptosis Pathway in High-Fat Diet-Induced C57BL/6 Mice

et al. 2022

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This study was conducted to evaluate the protective effect of Juglans regia (walnut, Gimcheon 1ho cultivar, GC) on high-fat diet (HFD)-induced cognitive dysfunction in C57BL/6 mice. The main physiological compounds of GC were identified as pedunculagin/casuariin isomer, strictinin, tellimagrandin I, ellagic acid-O-pentoside, and ellagic acid were identified using UPLC Q-TOF/MS analysis. To evaluate the neuro-protective effect of GC, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), 2′,7′-dichlorodihydrofluorecein diacetate (DCF-DA) analysis were conducted in H2O2 and high glucose-induced neuronal PC12 cells and hippocampal HT22 cells. GC presented significant cell viability and inhibition of reactive oxygen species (ROS) production. GC ameliorated behavioral and memory dysfunction through Y-maze, passive avoidance, and Morris water maze tests. In addition, GC reduced white adipose tissue (WAT), liver fat mass, and serum dyslipidemia. To assess the inhibitory effect of antioxidant system deficit, lipid peroxidation, ferric reducing antioxidant power (FRAP), and advanced glycation end products (AGEs) were conducted. Administration of GC protected the antioxidant damage against HFD-induced diabetic oxidative stress. To estimate the ameliorating effect of GC, acetylcholine (ACh) level, acetylcholinesterase (AChE) activity, and expression of AChE and choline acetyltransferase (ChAT) were conducted, and the supplements of GC suppressed the cholinergic system impairment. Furthermore, GC restored mitochondrial dysfunction by regulating the mitochondrial ROS production and mitochondrial membrane potential (MMP) levels in cerebral tissues. Finally, GC ameliorated cerebral damage by synergically regulating the protein expression of the JNK signaling and apoptosis pathway. These findings suggest that GC could provide a potential functional food source to improve diabetic cognitive deficits and neuronal impairments.

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Effect of Walnut on Lipid Profile in Obese Female in Different Ethnic Groups of Quetta, Pakistan

Cited by 3 publications

References 9 publications

Effects of Walnut on Lipid Profile as Well as the Expression of Sterol-Regulatory Element Binding Protein-1c(SREBP-1c) and Peroxisome Proliferator Activated Receptors <i>α</i> (PPAR<i>α</i>) in Diabetic Rat

Effects of Walnut on Lipid Profile as Well as the Expression of Sterol-Regulatory Element Binding Protein-1c(SREBP-1c) and Peroxisome Proliferator Activated Receptors <i>α</i> (PPAR<i>α</i>) in Diabetic Rat

Effect of Locally Manufactured Niger Seed Oil on Lipid Profile Compared to Imported Palm and Sunflower Oils on Rat Models

Walnut Prevents Cognitive Impairment by Regulating the Synaptic and Mitochondrial Dysfunction via JNK Signaling and Apoptosis Pathway in High-Fat Diet-Induced C57BL/6 Mice

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Effect of Walnut on Lipid Profile in Obese Female in Different Ethnic Groups of Quetta, Pakistan

Cited by 3 publications

References 9 publications

Effects of Walnut on Lipid Profile as Well as the Expression of Sterol-Regulatory Element Binding Protein-1c(SREBP-1c) and Peroxisome Proliferator Activated Receptors &lt;i&gt;α&lt;/i&gt; (PPAR&lt;i&gt;α&lt;/i&gt;) in Diabetic Rat

Effects of Walnut on Lipid Profile as Well as the Expression of Sterol-Regulatory Element Binding Protein-1c(SREBP-1c) and Peroxisome Proliferator Activated Receptors &lt;i&gt;α&lt;/i&gt; (PPAR&lt;i&gt;α&lt;/i&gt;) in Diabetic Rat

Effect of Locally Manufactured Niger Seed Oil on Lipid Profile Compared to Imported Palm and Sunflower Oils on Rat Models

Walnut Prevents Cognitive Impairment by Regulating the Synaptic and Mitochondrial Dysfunction via JNK Signaling and Apoptosis Pathway in High-Fat Diet-Induced C57BL/6 Mice

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Effects of Walnut on Lipid Profile as Well as the Expression of Sterol-Regulatory Element Binding Protein-1c(SREBP-1c) and Peroxisome Proliferator Activated Receptors <i>α</i> (PPAR<i>α</i>) in Diabetic Rat

Effects of Walnut on Lipid Profile as Well as the Expression of Sterol-Regulatory Element Binding Protein-1c(SREBP-1c) and Peroxisome Proliferator Activated Receptors <i>α</i> (PPAR<i>α</i>) in Diabetic Rat