Effect of Vitamin E Supplementation on Plasma Nitric Oxide in Menopausal Women with Hot Flashes: A Cross-Over, Randomized Clinical Trial

Rezasoltani, Parvaneh; Elliyoun, Nahid; Ziaie, Tahereh; Leyli, Ehsan Kazemnezhad; Aski, Soudabeh Kazemi; Sobhani, Abdolrasoul

doi:10.5812/ircmj.68800

Cited by 3 publications

(15 citation statements)

References 25 publications

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“…The participants were allocated to three groups in three studies [23][24][25] and two groups in seven studies. [25][26][27][28][29][30][31] In all of the studies, the control group received a placebo.…”

Section: Methodsmentioning

confidence: 99%

“…Nine studies were conducted in Iran [23][24][25][26][27][28][29][30][31] and one study in the United States. 31…”

Section: Study Locationmentioning

confidence: 99%

“…In one study, 23 the participants received 200 IU vitamin E capsules twice a day for 8 weeks. In the Ziaei et al study (2007), the participants received 400 IU vitamin E capsules per day for 8 weeks 26 In the study by Rezasoltani et al, (2018), the participants received 400 IU vitamin E capsules per day for 4 weeks in the first phase. 27 In two studies, 28,29 the participants received 850 mg vitamin E and omega-3 capsules per day for 12 weeks.…”

Section: Types Of Interventionsmentioning

confidence: 99%

“…In the Ziaei et al study (2007), the participants received 400 IU vitamin E capsules per day for 8 weeks 26 In the study by Rezasoltani et al, (2018), the participants received 400 IU vitamin E capsules per day for 4 weeks in the first phase. 27 In two studies, 28,29 the participants received 850 mg vitamin E and omega-3 capsules per day for 12 weeks. In three studies, 24,25,31 the participants received 1000 mg omega-3 capsules per day for 12 weeks.…”

Section: Types Of Interventionsmentioning

confidence: 99%

“…The frequency of hot flushes was evaluated based on daily records in eight studies. 22,[24][25][26][27][29][30][31] It was not mentioned in two studies. 24,29 The Menopause Rating Scale (MRS) was used in three studies to assess the intensity of hot flushes.…”

Section: Outcome Measuresmentioning

confidence: 99%

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The effect of oral vitamin E and omega-3 alone and in combination on menopausal hot flushes: A systematic review and meta-analysis

2022

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This systematic review was conducted to investigate the effects of vitamin E and omega-3 used alone and in combination on the frequency and intensity of hot flushes (primary outcomes) and adverse effects (secondary outcome) in menopausal women. English and Persian databases were searched until March 18, 2021. The quality of the published papers was evaluated using Cochrane Handbook and the meta-analysis was conducted in RevMan 5.3. Heterogeneity was assessed using I2. In cases with substantial heterogeneity, a random effects model was used instead of a fixed effects model. A total of 387 papers were obtained from the databases. Finally, 10 papers with a sample size of 1100 participants entered the systematic review and a meta-analysis was conducted on nine of them. The results of the meta-analysis of two studies indicated that using vitamin E and omega-3 in combination significantly reduced the intensity of hot flushes compared to the placebo (mean difference (MD): −0.35; 95% CI: −0.48 to −0.21). The mean frequency (MD: −0.50; 95% CI: −1.58 to 0.58) and intensity (SMD: −0.61; 95% CI: −1.50 to 0.29) of hot flushes in the omega-3 group and the frequency of hot flushes (SMD: −0.21; 95% CI: −0.47 to 0.04) in the vitamin E group showed no significant differences with the placebo. No serious adverse effects were reported in the studies. Given the low number of RCTs, more clinical trials with larger sample size are required.

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Section: Methodsmentioning

confidence: 99%

“…Nine studies were conducted in Iran [23][24][25][26][27][28][29][30][31] and one study in the United States. 31…”

Section: Study Locationmentioning

confidence: 99%

Section: Types Of Interventionsmentioning

confidence: 99%

Section: Types Of Interventionsmentioning

confidence: 99%

Section: Outcome Measuresmentioning

confidence: 99%

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The effect of oral vitamin E and omega-3 alone and in combination on menopausal hot flushes: A systematic review and meta-analysis

2022

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Antioxidant capacity and menopausal symptoms

Sotoudeh

Abshirini

2020

Aging

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Factors associated with high placebo response in clinical studies of hot flashes: a meta-analysis

2021

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Importance: High placebo response can often mask the evaluation of active treatment in clinical studies for women with hot flashes and potentially undermine the evaluation of new treatments.Objective: The aim of this meta-analysis was to determine the factors associated with high placebo response (defined as the reduction in the mean number of hot flash frequency from baseline) in randomized, controlled, double-blind studies enrolling women with hot flashes.Evidence Review: To identify eligible studies, Embase, MEDLINE, and BIOSIS Previews were searched for English-language articles published between April 1975 and August 2020. Placebo-controlled, double-blind, randomized studies that assessed changes in hot flash frequency were included if they satisfied the defined criteria. We conducted univariate and multivariate analyses using categorical and numerical data. Categorical data included the following variables and levels in brackets: active treatment type (hormone therapy /non-hormone therapy / complementary and alternative medicine), administration route (oral/non-oral), study region (in/excluded the US), breast cancer population (in/excluded), entry criteria of hot flash severity (moderate to severe only/all included), parallel or crossover study, placebo run-in period before treatment (yes/no), and menopausal status (postmenopausal only/include perimenopausal/include premenopausal). Numerical data included published year, pretreatment period duration, treatment period duration, number of sites, number of total participants, number of placebo participants, number of treatment arms, mean age, BMI, and hot flash frequency at baseline.Findings: Forty-three of the 802 identified publications were included in the review. Multivariate analysis identified three individual factors associated with high placebo response: treatment period duration, number of treatment arms, and BMI.Conclusions and Relevance: We identified several factors associated with high placebo response in clinical studies of women with hot flashes. Knowing these factors may enable proactive implementation of operational and analytic strategies that further aid in determining the true treatment effect of an intervention.

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Effect of Vitamin E Supplementation on Plasma Nitric Oxide in Menopausal Women with Hot Flashes: A Cross-Over, Randomized Clinical Trial

Cited by 3 publications

References 25 publications

The effect of oral vitamin E and omega-3 alone and in combination on menopausal hot flushes: A systematic review and meta-analysis

The effect of oral vitamin E and omega-3 alone and in combination on menopausal hot flushes: A systematic review and meta-analysis

Antioxidant capacity and menopausal symptoms

Factors associated with high placebo response in clinical studies of hot flashes: a meta-analysis

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