Effect of vitamin E on oxidative stress level in blood, synovial fluid, and synovial tissue in severe knee osteoarthritis: a randomized controlled study

Tantavisut, Saran; Tanavalee, Aree; Honsawek, Sittisak; Suantawee, Tanyawan; Ngarmukos, Srihatach; Adisakwatana, Sirichai; Callaghan, John J.

doi:10.1186/s12891-017-1637-7

Cited by 30 publications

(22 citation statements)

References 29 publications

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“…Evidence from previous studies indicated that oxidative stress may have a critical role in the pathophysiology of OA. There are many studies investigating levels of oxidative markers in the blood and the SF samples of OA patients . However, the results are still controversial and it is not fully understood whether SF increases or decreases the status of oxidative stress .…”

Section: Discussionmentioning

confidence: 99%

“…There are many studies investigating levels of oxidative markers in the blood and the SF samples of OA patients. 32,34,35 However, the results are still controversial and it is not fully understood whether SF increases or decreases the status of oxidative stress. 36,37 Moreover, it is difficult to discriminate the difference among the statuses of oxidative stress in different stages of knee OA.…”

Section: Discussionmentioning

confidence: 99%

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Association of UCMA levels in serum and synovial fluid with severity of knee osteoarthritis

et al. 2019

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Aim Osteoarthritis (OA) is one of the most common joint diseases causing physical disability in the aged population. OA pathogenesis is not fully known and yet there are no effective therapeutic options against OA. Upper Zone of Growth Plate and Cartilage Matrix Associated (UCMA) is a member of vitamin K‐dependent protein family, and is involved in inflammation, cardiovascular diseases, cancer, and OA. In the present study, our aim was to detect serum and synovial fluid (SF) levels of UCMA and to analyze their correlation with radiographic findings and symptomatic severity in OA patients as well as the correlation between oxidative stress levels and SF UCMA levels. Methods Forty OA patients with cartilage degeneration and 20 patients with other knee joint disorders (non‐OA control) were included in the present study. We used the Kellgren‐Lawrence (KL) classification and Western Ontario McMaster University Osteoarthritis Index (WOMAC) scores to assess radiographic grading and symptomatic severity of OA, respectively. UCMA levels were measured in SF and serum. And also oxidative stress markers were analyzed in SF. Results SF UCMA levels of OA patients were higher compared to those of the non‐OA control group and were positively correlated with radiographic finding and symptomatic severity of OA. However, there was no significant correlation between oxidative markers of SF and the KL grade, WOMAC scores, and SF UCMA levels in OA patients. Conclusion There is a close connection between UCMA SF levels and symptomatic and radiographic severities of knee OA. Therefore, UCMA can be a promising biomarker in the diagnosis and/or prognosis of OA disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association of UCMA levels in serum and synovial fluid with severity of knee osteoarthritis

et al. 2019

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“…Firstly, it only focuses on the anti-osteoarthritis effects of olive oil and its polyphenols. However, other compounds present in olive oil, such as alpha-tocopherol (the predominant form of vitamin E in nature), oleic and linoleic acids (both are the predominant unsaturated fatty acids in olive oil) also possess antioxidant and anti-inflammatory effects, which might contribute to the anti-osteoarthritic properties of olive oil [ 142 , 143 ]. All these compounds could act synergistically to provide better chondroprotective effects than olive polyphenols alone.…”

Section: Perspectives On the Use Of Olive And Its Derivatives In Cmentioning

confidence: 99%

Therapeutic Effects of Olive and Its Derivatives on Osteoarthritis: From Bench to Bedside

Chin

Pang

2017

Nutrients

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Osteoarthritis is a major cause of morbidity among the elderly worldwide. It is a disease characterized by localized inflammation of the joint and destruction of cartilage, leading to loss of function. Impaired chondrocyte repair mechanisms, due to inflammation, oxidative stress and autophagy, play important roles in the pathogenesis of osteoarthritis. Olive and its derivatives, which possess anti-inflammatory, antioxidant and autophagy-enhancing activities, are suitable candidates for therapeutic interventions for osteoarthritis. This review aimed to summarize the current evidence on the effects of olive and its derivatives, on osteoarthritis and chondrocytes. The literature on animal and human studies has demonstrated a beneficial effect of olive and its derivatives on the progression of osteoarthritis. In vitro studies have suggested that the augmentation of autophagy (though sirtuin-1) and suppression of inflammation by olive polyphenols could contribute to the chondroprotective effects of olive polyphenols. More research and well-planned clinical trials are required to justify the use of olive-based treatment in osteoarthritis.

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“…Inconsistent findings were observed in GLM extracts (Lau et al, 2004;Stebbings et al, 2017), vitamin E (Brand et al, 2001;Tantavisut et al, 2017), MSM (Kim et al, 2006;Debbi et al, 2011), rose hip (Warholm et al, 2003;Ginnerup-Nielsen et al, 2015), LFO (Kinoshita et al, 2017), ginger (Alipour et al, 2016Altman and Marcussen, 2001;Niempoog et al, 2012;Zakeri et al, 2011) and willow bark extract (Schmid et al, 2001).…”

Section: Dietary Supplements With Mixed Resultsmentioning

confidence: 96%

Antioxidant and anti-inflammatory dietary supplements in the treatment of osteoarthritis: a scoping review

Ong¹,

Sakinah²,

Shahril³

et al. 2019

Food Res.

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The increasing number of evidence has reported inflammation and oxidative stress as key mediators of osteoarthritis (OA) joint pathology. Therefore, the usage of dietary supplements targeting inflammation and oxidative stress in OA may emerge as a rewarding therapeutic strategy. This study aimed to explore the efficacy of antioxidant and anti-inflammatory dietary supplements used to manage OA. A methodological framework proposed by Arksey and O’Malley was used to conduct this scoping review. An electronic database search of English academic articles was conducted using PubMed, MEDLINE and ScienceDirect from 2000 to 2018. Randomized controlled trials (RCTs) of OA with parallel groups by comparing dietary supplements with placebo consumption were eligible for inclusion. Out of 69,150 studies identified, a total of 41 studies were included, with 25 antioxidant or anti-inflammatory dietary supplements identified. There were 3325 respondents (1740 in the treatment group and 1585 in the placebo group), all aged ≥ 25 years old and comprised of 69.6% and 30.4% female and male respondents, respectively. The majority of the studies recruited participants with knee OA (n = 33) with a follow-up duration of 3 to 32 weeks. Overall, most of the dietary supplements (n =17) demonstrated a beneficial effect on the clinical signs and symptoms, such as Boswellia serrata extract (BSE), Pycnogenol and L-carnitine. In contrast, Aquamin supplementation did not exert positive impacts on OA management, while inconsistent findings were observed in greenlipped mussel (GLM) extract, vitamin E, methylsulfonylmethane (MSM), licorice flavonoid oil (LFO), ginger, willow bark extract and rose hip supplementation. In summary, the role of anti-inflammatory and antioxidant dietary supplements cannot be ignored as they can offer alleviated pain and symptom relief.

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Effect of vitamin E on oxidative stress level in blood, synovial fluid, and synovial tissue in severe knee osteoarthritis: a randomized controlled study

Cited by 30 publications

References 29 publications

Association of UCMA levels in serum and synovial fluid with severity of knee osteoarthritis

Association of UCMA levels in serum and synovial fluid with severity of knee osteoarthritis

Therapeutic Effects of Olive and Its Derivatives on Osteoarthritis: From Bench to Bedside

Antioxidant and anti-inflammatory dietary supplements in the treatment of osteoarthritis: a scoping review

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