Therapeutic Effects of Olive and Its Derivatives on Osteoarthritis: From Bench to Bedside

Abstract

Osteoarthritis is a major cause of morbidity among the elderly worldwide. It is a disease characterized by localized inflammation of the joint and destruction of cartilage, leading to loss of function. Impaired chondrocyte repair mechanisms, due to inflammation, oxidative stress and autophagy, play important roles in the pathogenesis of osteoarthritis. Olive and its derivatives, which possess anti-inflammatory, antioxidant and autophagy-enhancing activities, are suitable candidates for therapeutic interventions for osteoarthritis. This review aimed to summarize the current evidence on the effects of olive and its derivatives, on osteoarthritis and chondrocytes. The literature on animal and human studies has demonstrated a beneficial effect of olive and its derivatives on the progression of osteoarthritis. In vitro studies have suggested that the augmentation of autophagy (though sirtuin-1) and suppression of inflammation by olive polyphenols could contribute to the chondroprotective effects of olive polyphenols. More research and well-planned clinical trials are required to justify the use of olive-based treatment in osteoarthritis.

AB0090 Verbascoside and hydroxytyrosol downregulate stress-related pathways in human osteoarthritic articular chondrocytes

“…2 Recent studies have revealed the essential role of plant-derived antioxidants in preventing pathophysiological events observed in joint diseases by modulating redox signalling. 3 Objectives: Here, we studied whether the polyphenolic compounds verbascoside and hydroxytyrosol exert chondroprotective effects by suppressing oxidative stress pathways and IL-1, IL-1b-converting enzyme (ICE) expression in human OA chondrocytes. Methods: Chondrocytes were isolated from the joint cartilages of OA patients (grade 3-4) during total knee arthroplasty with the approval of Kecioren Training and Research Hospital, Clinical Research Ethics Committee (B.10.4.…”

Safety Evaluations of Single Dose of the Olive Secoiridoid S-(−)-Oleocanthal in Swiss Albino Mice

“…This means the average daily consumption of Mediterranean individuals ranges from 0.3/0.5 mg to 36/60 mg OC, depending on the consumed EVOO quality [1,2]. Meanwhile, the high dietary intake of EVOO is considered as a mediator for lowering the incidences of several diseases such as cardiovascular and metabolic diseases, different types of malignancies, Alzheimer's disease, and osteoporosis [3][4][5][6][7][8][9]. In addition, EVOO phenolic compounds are well known to possess different biological activities including antioxidant, anti-inflammation, anticancer and anti-diabetic activities [10][11][12][13].…”

AB0087 Synovial tissue macrophages polarisation (M1, M2) in patients with undifferentiated arthritismeeting diagnostic criteria for rheumatoid arthritis or psoriatic arthritis along the follow up

“…At the molecular level, degeneration of the cartilage is attributed to multifactorial events including oxidative stress, mitochondrial dysfunction, apoptosis and associated changes in inflammatory and catabolic gene expression 2. Recent studies have revealed the essential role of plant-derived antioxidants in preventing pathophysiological events observed in joint diseases by modulating redox signalling 3. Objectives: Here, we studied whether the polyphenolic compounds verbascoside and hydroxytyrosol exert chondroprotective effects by suppressing oxidative stress pathways and IL-1, IL-1b-converting enzyme (ICE) expression in human OA chondrocytes.Methods: Chondrocytes were isolated from the joint cartilages of OA patients (grade 3-4) during total knee arthroplasty with the approval of Kecioren Training and Research Hospital, Clinical Research Ethics Committee (B.10.4.…”