Effect of Vitamin E on Haematological Parameters in Albino Rats Treated with Gasoline

George, Melvin; Adegoke, A O

doi:10.3329/jsr.v4i2.7670

Cited by 5 publications

(7 citation statements)

References 12 publications

(7 reference statements)

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“…Antioxidants are the type of molecules that nullify harmful free radicals, produced through a series of reactions ( Joseph et al., 2009 ; George and Adegoke, 2011 , 2012 ; Tanko et al., 2013 ), that are detrimental to living cells, spoil foods, damage materials such as rubber, gasoline, and lubricating oil. Antioxidants terminate these series of reactions through the elimination of free radical intermediates and inhibiting other oxidation reactions ( Sies, 1997 ).…”

Section: Discussionmentioning

confidence: 99%

“…In this study, the administration of 10 mg AA/kg bw reduced the WBC counts significantly in the rats compared with the control group. This finding suggests that AA (an antioxidant) might be capable of preventing excessive production of WBC ( Liu, 1995 ; George and Adegoke, 2012 ). The significant increase in WBC count in 10 mg SB/kg bw group compared with the control group indicated that SB was recognized as a foreign entity.…”

Section: Discussionmentioning

confidence: 99%

“…It is a natural antioxidant that stops the continuous creation of free radicals induced by oxidative damage to lipids and lipoproteins in various cellular sections and tissues ( Costa et al., 2004 ; George and Adegoke et al., 2011 . 2012 ; Musa et al., 2012 ). It is regarded generally as a critical first-line defensive agent that repairs or nullifies free radicals by donating a single electron, followed by a proton to yield a dehydroascorbic acid ( Carr et al., 2000 ; Halliwell, 2001 ).…”

Section: Introductionmentioning

confidence: 99%

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Effects of commonly used food additives on haematological parameters of Wistar rats

Femi-Oloye

Owoloye

Olatunji-Ojo

et al. 2020

Heliyon

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This study was done to investigate the effects of common food additives such as sodium benzoate (SB) and ascorbic acid (AA) on haematological parameters of male Wistar rats. Forty-eight (48) male albino rats with an average weight of 105 g were grouped into twelve (n = 4) of Basal Control and other 11 groups orally administered 1 mg of SB, 10 mg of SB, 10 mg of AA, 0.2 mg of AA + 0.5 mg of SB, 0.2 mg of AA + 1 mg of SB, 0.2 mg of AA + 10 mg of SB, 0.2 mg of SB + 0.1 mg of AA, 0.2 mg of SB + 0.5 mg of AA, carbonated soft drinks (CSD)+ 0.1 mg of AA, CSD + 1 mg of AA and CSD + 10 mg of AA, respectively for 21 non-consecutive days. At the end of the experiment, blood samples were collected in EDTA anticoagulant tubes, haematological parameters were evaluated, and data were analyzed. There was a dose-dependent increase (p < 0.05) in White Blood Cell counts of SB treated rats compared with the control group. The lymphocyte exhibited significant reduction (p < 0.05) in the groups treated with 1mg SB and 10mg SB/kg bodyweight of 67 ± 2.96 and 58 ± 4.18%, respectively. The mean corpuscular haemoglobin showed no significant difference at 95% confidence interval. However, mean corpuscular haemoglobin concentration, haematocrit and platelet were affected by an increase in the concentrations of SB. High SB concentrations increased the destruction of erythrocytes, which directly increased the catabolism of haemoglobin. However, AA administration mitigated the adverse effects of SB on the haematological parameters of the animal.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of commonly used food additives on haematological parameters of Wistar rats

Femi-Oloye

Owoloye

Olatunji-Ojo

et al. 2020

Heliyon

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“…Vitamin E has been shown to ameliorate hemolysis of red blood cells 24. A study by George and Adoke suggested that gasoline induced hemolysis of red blood cells in albino rats could be prevented by feeding them vitamin E rich diet showing the antioxidant property of this vitamin against hemotoxicity 26. Role of vitamin E as an erythrocyte forming factor was demonstrated in a study by Gogu et al in a murine model 27.…”

Section: Introductionmentioning

confidence: 99%

Vitamin E deficiency in South Asian population and the therapeutic use of alpha-tocopherol (Vitamin E) for correction of anemia

Jilani¹,

Iqbal²

2018

Pak J Med Sci

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Mild to moderate vitamin E deficiency because of inadequate consumption of vitamin E-rich foods and intestinal fat malabsorption is common in growing children, women of reproductive age and elderly South Asian population. Severe vitamin E deficiency may lead to peripheral and motor neurodegenerative diseases (e.g ataxia and motor skeletal myopathy), impaired immune response and free radical-induced hemolytic anemias. Vitamin E insufficiency and/or deficiency status in the general Pakistani population has not been sufficiently investigated. Moreover, there are challenges in determining vitamin E status in apparently healthy humans due to variations in their age, sources of consumed vitamin E and plasma lipid levels. Oxidative stress-induced reactive oxygen species have been shown to cause ineffective erythropoiesis and enhanced lysis of erythrocytes in some of the experimental animals and humans. Several studies on patients with various types of inherited hemolytic anemias, chronic renal disease, premature low birth infants and apparently healthy humans have shown that vitamin E might be therapeutically effective in the prevention and/ or treatment of anemia in these subjects.

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“…In the current study, treatment with vitamin E showed a significant increase in hemoglobin (Hb) content only in (500 mg/kg) treated group and after 45 days recovery, while non-significantly decreased in (1000 and 2000 mg/kg) treated groups for 90 days of treatment and after 45 days recovery in the comparison with control group. The increase in Hb content after treatment with the lowest dose of vitamin E (500 mg/kg) might be due to its antioxidant effects (George and Adegoke, 2012). A study by Abdo et al (1986) revealed that treatment with a high dose of vitamin E (2000 mg/kg) for 13 weeks caused a decrease in hematocrit values and Hb concentrations.…”

Section: Discussionmentioning

confidence: 99%

Evaluate Subchronic Toxic Effects of Repeated Exposure of Megadoses of Vitamin E in Male Albino Rats

Hassan

ELaraby

El-Hak

et al. 2019

Egyptian Academic Journal of Biological Sciences, B. Zoology

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Vitamin E (α-tocopherol) is a potent antioxidant and possesses an important role in deactivating free radicals in the cells and preventing the hazardous effects of reactive oxygen species thus stopping the lipid peroxidation process. However, the overdosing of a vitamin is toxic and leads to many harmful effects. The current work aimed to assess the potential subchronic toxicity of vitamin E megadoses for 90 days of treatment and after 45 days of recovery. Forty-seven male albino rats weighting (120-140 g) were used in this study and were divided into seven groups each of seven animals. The normal control group, three groups treated with (500, 1000, and 2000 mg/kg) of vitamin E for successive 90 days, and the last three groups were treated with the same doses and left 45 days for recovery. The results showed that higher doses of vitamin E had significantly increased liver enzymes ALT and AST, MDA, and altered hematological parameters. The toxicity was proportional to the dose and recovery period showed maintained liver toxicity while kidney regains their normal function. The study concluded that although vitamin E reported being a potent antioxidant, it is very toxic unless it had used within the range of recommended doses and should be used under the prescription of the physicians

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Effect of Vitamin E on Haematological Parameters in Albino Rats Treated with Gasoline

Cited by 5 publications

References 12 publications

Effects of commonly used food additives on haematological parameters of Wistar rats

Effects of commonly used food additives on haematological parameters of Wistar rats

Vitamin E deficiency in South Asian population and the therapeutic use of alpha-tocopherol (Vitamin E) for correction of anemia

Evaluate Subchronic Toxic Effects of Repeated Exposure of Megadoses of Vitamin E in Male Albino Rats

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