Effect of Vitamin E and Selenium on Blood Composition of the Young Pig

Effect of Polyunsaturated Fatty Acids and Vitamin E Level of the Sow Gestation Diet on Reproductive Performance and on Level of Alpha Tocopherol in Colostrum, Milk and Dam and Progeny Blood Serum

“…It is well known that diets high in polyunsaturated fatty acids increase the vitamin E requirement (Dam, 1962;Roels, 1967). Selenium has been shown to be more effective than vitamin E in preventing exudative diathesis in chicks (Nesheim and Scott, 1958;Scott, 1962), muscular dystrophy in lambs (Proctor et al, 1958) and calves (Muth et al, 1961) and liver necrosis in pigs (Eggert et al, 1957;Ewan and Wastell, 1970). Selenium functions as a component of glutathione peroxidase (Rotruck et al, 1973;Noguchi et al, 1973); this role in destruction of peroxidase formed on oxidation of lipids may explain the protective effect of selenium against vitamin E deficiency diseases and provide the basis for the similarity in the action of vitamin E and selenium.…”

Studies of selenium-vitamin E deficiency produced experimentally in young pigs

“…Previous reports (Ewan and Wastell, 1970;Grant, I96I;Mahan et al, 1973;Piper et al, 1975;Tollersrud and Nafstad, 1970;Van Vleet et , 1975) (Gibson et al, 1955)• Consequently, the conversion of aminolevulinic acid to porphobilinogen is partially or completely inhibited. A laboratory method for assaying activity of this enzyme in blood was described (Burch and Siegel, 1971 ;Weissberg et al, 1971) Weissberg ^ al., 1971).…”

Studies of selenium-vitamin E deficiency produced experimentally in young pigs

“…Previous reports (Ewan and Wastell, 1970; Grant, I96I; Mahan et al, 1973;Piper et al, 1975;Tollersrud and Nafstad, 1970;Van Vleet et , 1975) have associated increased activity of serum or plasma glutamic oxaloacetic transaminase with lesions of selenium and/or vitamin E deficiency in swine.…”

“…Significant increases in activity levels of serum glutamic pyruvate transaminase (GPT), lactic acid dehydro genase (LDH) (Ewan and Wastell, 1970 ;Ruth and Van Vlee% 197^5 Tollersrud and Nafstad;; ornithine carbamyl trans ferase (OCT) (Michel et al,I969), creatine phosphokinase (CPK), isocitric dehydrogenase (ICD), and alpha-hydroxybutyric acid dehydrogenase (HBD) (Ruth and Van Vleet,197^) have been reported in swine fed diets that are deficient in selenium and vitamin E. Tollersrud and Nafstad (1970) have correlated specific morphologic lesions of vitamin E deficiency syndrome with changes in activity levels of GOT, GPT, LDH and ICD in serum. by exerting its inhibitory effect on this enzymic step (Gibson et al, 1955)• Consequently, the conversion of aminolevulinic acid to porphobilinogen is partially or completely inhibited.…”