Effect of vitamin E and C supplements on lipid peroxidation and GSH-dependent antioxidant enzyme status in the blood of women consuming oral contraceptives

Zal, Fatemeh; Mostafavi‐Pour, Zohreh; Amini, Fatemeh; Heidari, Ataollah

doi:10.1016/j.contraception.2011.11.006

Cited by 35 publications

(28 citation statements)

References 32 publications

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“…Natural antioxidants such as black and green tea,epigallocatechin gallate (20),quercetin, and vitamin E (21) decrease the circulation of NO with protective effects on blood pressure, vascular health, endothelial function, inflammation, and insulin sensitivity. Several studies showed that natural antioxidants such as α-carbolines, α-tocopherol (22),quercetin, and coenzyme Q10 (23) improve NO in vivo. In addition, MPO is an appropriate marker for the evaluation of oxidant/antioxidant, inflammatory, and atherogenic status (5).…”

Section: Discussionmentioning

confidence: 99%

Protective effects of oleuropein against renal injury oxidative damage in alloxan-induced diabetic rats; a histological and biochemical study

Ahmadvand¹,

Shahsavari²,

Tavafi³

et al. 2017

J Nephropathol

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Background: Oleuropein is a potent antioxidant and free-radical scavenger with antiinflammatory properties. Objectives: In the present study, we evaluated the protective effects of oleuropein on myeloperoxidase (MPO) activity, nitrite, urea, creatinine and glomerulosclerosis in alloxan-induced type 1 diabetic rats. Materials and Methods: Thirty Sprague-Dawley male rats were randomly divided into 3 groups: group 1 as control; group 2 as untreated diabetic; and group 3 as treated with oleuropein 15 mg/kg i.p daily. Diabetes was induced in the second and third groups by subcutaneous alloxan injection. After 48 days, the animals were anaesthetized and then the livers and kidneys were removed immediately and used fresh or kept frozen until MPO activity analysis. Blood samples were also collected before sacrificing to measure nitrite, urea, and creatinine. Kidney paraffin sections were prepared to estimate glomerular volume, leukocyte infiltration, and glomerulosclerosis. Results: Oleuropein significantly decreased leukocyte infiltration and glomerulosclerosis in the treated group compared with the diabetic untreated group. Oleuropein significantly decreased the levels of urea, nitrite, and creatinine in the treated group compared with the diabetic untreated group. Moreover, oleuropein significantly decreased MPO activity in the treated group compared with the diabetic untreated group. Conclusions: Oleuropein has antioxidative and antiatherogenic activities and exerts beneficial effects on inflammation and kidney function test and decreases diabetic complication in diabetic rats.

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Section: Discussionmentioning

confidence: 99%

Protective effects of oleuropein against renal injury oxidative damage in alloxan-induced diabetic rats; a histological and biochemical study

Ahmadvand¹,

Shahsavari²,

Tavafi³

et al. 2017

J Nephropathol

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“…Mechanisms leading to elevation of hydroperoxides by OC are still not de nitively characterized (31), however, some evidence point to oxidative hepatotoxicity of OC (12). P450 cytochromes (CYPs) catabolizing exogenous hormones can cause increased ROS production (51) and, in turn, hyper-production of free radicals could provoke depletion of antioxidant defenses such as depletion of reduced glutathione (31,33). However, the role of estrogens and progestogens in OC induced oxidative stress is still debated (20,31,52).…”

Section: Oxidative Stressmentioning

confidence: 99%

“…Rather surprisingly, however, no study ever examined the relationship between oxidative stress and low-grade in ammatory status in a sample of childbearing age women according to OC use. Importantly, both oxidative stress and low-grade in ammatory status can, at least in part, be modulated by lifestyles, including physical activity (24,28,(30)(31)(32)(33)(34)(35).…”

Section: Introductionmentioning

confidence: 99%

Increase of Oxidative Stress is Positively Associated with High-Sensitivity C-Reactive Protein in Women Using Combined Oral Contraceptives: An Observational Study

Cauci

Francescato

Colannino

et al. 2020

Preprint

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Background Information concerning oxidative stress and low-grade inflammation in oral contraception users is scarce. We investigated relationships of oxidative stress and high-sensitivity C-reactive protein (hsCRP) in women by oral combined contraceptive (OC) use. Methods Caucasian Italian healthy non-obese women (n = 290; 100 OC-users; 190 non-OC-users; mean age 23.2 ± 4.7 years) were analyzed. Blood hydroperoxides, as oxidative stress biomarkers, were assessed by Free Oxygen Radical Test (FORT), and serum hsCRP was determined by routine methods. Results Oxidative stress levels were elevated (≥ 400 FORT Units) in 77.0% and 15.8% of OC-users and non-OC-users, respectively (odds ratio (OR) = 209, 95%CI = 60.9-715.4, p < 0.001); hsCRP levels ≥ 2.0 mg/L were found in 41.0% and 9.5% of OC-users and non-users, respectively (OR = 6.6, 95%CI 3.5–12.4, p < 0.001). Continuous hydroperoxides values in OC-users were 1.7-fold higher compared to non-users (median 472 versus 270 FORT Units, p < 0.001); OC-users had 3.7-fold higher hsCRP values compared to non-OC-users (median 1.31 versus 0.35 mg/L, p < 0.001). Hydroperoxides were strongly positively correlated to hsCRP in all women (rs=0.622, p < 0.001), in OC-users (rs=0.442, p < 0.001), and in non-OC-users (rs=0.426, p < 0.001). Women with hydroperoxides ≥ 400 FORT Units were 8 times as likely to have hsCRP ≥ 2 mg/L. In non-OC-users only, hydroperoxides values were positively correlated with weight and body mass index, but negatively correlated with red meat, fish and chocolate consumption. Conclusions Our cross-sectional observational study is the first finding a strong positive correlation of serum hydroperoxides with hsCRP, a marker of inflammation. Further research is needed to elucidate the potential role of these two biomarkers in OC-use side-effects, like thromboembolism.

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“…Furthermore, it has also been shown that the use of vitamins E and C reduces the side effects of OCs [18]. …”

Section: Introductionmentioning

confidence: 99%

Amelioration of lipid abnormalities by vitamin therapy in women using oral contraceptives

Torkzahrani

Heidari

Mostafavi‐Pour

et al. 2014

Clin Exp Reprod Med

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ObjectiveCombined oral contraceptives (COCs) have some adverse effects on the serum lipid profile. Because hyperlipidemia is one of the risk factors in cardiovascular diseases, lipid abnormalities should be evaluated in women consuming COCs. Vitamins E and C are known to have beneficial effects on serum lipid profiles. Therefore, in this study, we evaluated the effects of vitamins E and C on serum lipids in women using COCs.MethodsThe study compared changes in lipid parameters with and without vitamin therapy in women consuming COCs compared to those of a control group (40 non-contraceptive users or NCU) for 4 weeks. Total cholesterol and triglyceride, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels along with HDL/LDL ratios were measured for all participants.ResultsCOC users experienced significantly higher increases in the levels of triglycerides and LDL than non-users (p<0.05). However, no significant differences were noted in the total cholesterol and HDL levels. In the treated COC group receiving vitamins E and C, the HDL level and the HDL/LDL ratio increased and the LDL and triglycerides levels decreased significantly compared with those of the other groups.ConclusionThe results of our study indicate that supplementation with antioxidant vitamins E and C restores a normal lipid profile in COC users.

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Effect of vitamin E and C supplements on lipid peroxidation and GSH-dependent antioxidant enzyme status in the blood of women consuming oral contraceptives

Cited by 35 publications

References 32 publications

Protective effects of oleuropein against renal injury oxidative damage in alloxan-induced diabetic rats; a histological and biochemical study

Protective effects of oleuropein against renal injury oxidative damage in alloxan-induced diabetic rats; a histological and biochemical study

Increase of Oxidative Stress is Positively Associated with High-Sensitivity C-Reactive Protein in Women Using Combined Oral Contraceptives: An Observational Study

Amelioration of lipid abnormalities by vitamin therapy in women using oral contraceptives

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