Effect of Vitamin D Treatment on Glucose Homeostasis and Metabolism in Lebanese Older Adults: A Randomized Controlled Trial

Hajj, Cynthia El; Chardigny, J.M.; Boirie‌, Yves; Yammine, Kaissar; Helou, Mariana; Walrand, Stéphane

doi:10.1007/s12603-018-1083-8

Cited by 20 publications

(24 citation statements)

References 26 publications

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“…Our results showed no significant effect of vitamin D administration on HbA1c, even though a positive association was revealed between (25(OH) D) status and BMI. These results came in accordance with our previous study [35], that showed no relationship between (25(OH) D) status and HbA1c. Of note, our subjects had a lower BMI, while waist circumference was relatively high.…”

Section: Discussionsupporting

confidence: 93%

Effect of Vitamin D Supplementation on Inflammatory Markers in Non-Obese Lebanese Patients with Type 2 Diabetes: A Randomized Controlled Trial

et al. 2020

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Background: A low serum 25-hydroxyvitamin D (25(OH) D) concentration has been associated with a higher risk of type 2 diabetes mellitus (T2DM), especially in older people. Our aim in this randomized controlled trial was to evaluate the effect of vitamin D treatment on inflammatory markers in non-obese Lebanese patients with T2DM, living in Beirut, Lebanon. Methods: Non-Obese patients with T2DM (n = 88), deficient/insufficient in vitamin D, were randomly assigned into one of two groups—a treatment group receiving 30,000 IU cholecalciferol/week for a period of six months, and a placebo group. Serum concentrations of TNF-α, high-sensitivity C-reactive protein (hs-CRP), and Interleukin-6 (IL-6) were the primary outcomes. A homeostatic model of insulin resistance (HOMA-IR) was assessed, in addition to serum concentrations of fasting blood glucose (FBG), HbA1C, (25(OH) D), and PTH. Results: The vitamin D group showed higher blood levels of (25(OH) D) (p < 0.0001), and a significant reduction in hs-CRP and TNF-α concentrations (p < 0.0001) compared to placebo. The decrease perceived in IL-6 concentrations was not significant (p = 0.1). No significant changes were seen in FBG (p = 0.9) and HbA1c levels (p = 0.85). Conclusion: Six months of vitamin D supplementation led to a decrease in some inflammatory markers in patients with T2DM. Additional studies with a larger sample and a longer period are advised in this regard. This trial was registered at ClinicalTrial.gov; Identifier number: NCT 03782805.

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Section: Discussionsupporting

confidence: 93%

Effect of Vitamin D Supplementation on Inflammatory Markers in Non-Obese Lebanese Patients with Type 2 Diabetes: A Randomized Controlled Trial

et al. 2020

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“…Additionally, they also detected the significant elevation of quantitative insulin sensitivity check index (QUICKI) and HDL [ 8 ]. El Hajj et al have found that vitamin D triggers to significantly diminish of HOMA-IR, FPG, TC, and LDL, but without any significant changes in HbA1c [ 9 ]. The results of studies conducted by Barzegardi et al have presented pronounced decrease in serum levels of TG, LDL, and TC in diabetic nephropathy patients after supplementation with vitamin D [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

The Molecular Mechanisms by Which Vitamin D Prevents Insulin Resistance and Associated Disorders

Szymczak-Pajor

Drzewoski

Śliwińska

2020

IJMS

118

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Numerous studies have shown that vitamin D deficiency is very common in modern societies and is perceived as an important risk factor in the development of insulin resistance and related diseases such as obesity and type 2 diabetes (T2DM). While it is generally accepted that vitamin D is a regulator of bone homeostasis, its ability to counteract insulin resistance is subject to debate. The goal of this communication is to review the molecular mechanism by which vitamin D reduces insulin resistance and related complications. The university library, PUBMED, and Google Scholar were searched to find relevant studies to be summarized in this review article. Insulin resistance is accompanied by chronic hyperglycaemia and inflammation. Recent studies have shown that vitamin D exhibits indirect antioxidative properties and participates in the maintenance of normal resting ROS level. Appealingly, vitamin D reduces inflammation and regulates Ca2+ level in many cell types. Therefore, the beneficial actions of vitamin D include diminished insulin resistance which is observed as an improvement of glucose and lipid metabolism in insulin-sensitive tissues.

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“…While this study design minimized confounding factors, we did not observe an acute effect of 1000 IU of VitD 3 , 3g of BPH or VitD 3 + BPH treatments on glucose homeostasis (glucose, insulin, and C-Peptide). Although the effect of BPH on glucose homeostasis and lipid profile were not studied in RCT, discordant results were observed regarding the benefits of VitD 3 supplementation on glucose homeostasis [31,32,33]. A long-term study that tested the impact of 8-week VitD 3 supplementation (50,000 IU weekly) on TG levels in 25(OH)D deficient individuals [29] did not report improvements in lipid profile similarly to results obtained in the current acute study.…”

Section: Discussionmentioning

confidence: 99%

“…In view of these reports, Ponda and collaborators [29] concluded that the benefit inferred from cross-sectional associations of higher 25(OH)D levels and a healthier lipid profile was not replicated by acute VitD 3 repletion. Similarly, RCT also showed discordant results regarding the benefits of VitD 3 supplementation on glucose homeostasis [31,32,33].…”

Section: Introductionmentioning

confidence: 99%

Acute Effects of Single Doses of Bonito Fish Peptides and Vitamin D on Whole Blood Gene Expression Levels: A Randomized Controlled Trial

Guénard

Jacques

Gagnon

et al. 2019

IJMS

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Fish contains high quality proteins and essential nutrients including 25-hydroxyvitamin D (25(OH)D). Fish peptide consumption can lower cardiovascular disease (CVD) risk factors, and studies have shown an association between 25(OH)D deficiency, CVD and CVD risk factors, such as diabetes. This study investigated acute effects of a single dose of cholecalciferol (VitD3), bonito fish peptide hydrolysate (BPH), or a combination of both on CVD risk factors and whole blood gene expression levels. A randomized, crossover, placebo controlled trial was conducted in 22 adults. They ingested, in random order and at 7-day intervals, 1000 IU of VitD3, 3 g of BPH, a combination of both, or a placebo. A 180 min oral glucose tolerance test was performed. Differences in whole-genome expression levels after versus before each supplementation were computed for 18 subjects. We observed that 16, 1 and 5 transcripts were differentially expressed post- vs. pre-ingestion for VitD3, BPH or VitD3 + BPH treatments, respectively. VitD3-containing treatments affected the expression of the solute carrier family 25 member 20 (SLC25A20) gene involved in fatty acid oxidation, various transcription factors and genes related to glucose metabolism. These results suggest that VitD3 rapidly modulates genes related to CVD risk factors in blood while BPH seems to moderately modulate gene expression levels.

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Effect of Vitamin D Treatment on Glucose Homeostasis and Metabolism in Lebanese Older Adults: A Randomized Controlled Trial

Cited by 20 publications

References 26 publications

Effect of Vitamin D Supplementation on Inflammatory Markers in Non-Obese Lebanese Patients with Type 2 Diabetes: A Randomized Controlled Trial

Effect of Vitamin D Supplementation on Inflammatory Markers in Non-Obese Lebanese Patients with Type 2 Diabetes: A Randomized Controlled Trial

The Molecular Mechanisms by Which Vitamin D Prevents Insulin Resistance and Associated Disorders

Acute Effects of Single Doses of Bonito Fish Peptides and Vitamin D on Whole Blood Gene Expression Levels: A Randomized Controlled Trial

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