Effect of vitamin D supplementation on benign paroxysmal positional vertigo recurrence: A meta-analysis

Abstract

Benign paroxysmal positional vertigo is characterized by recurrence, which exposes patients to repeated vertigo attacks. Vitamin D deficiency has been found to be a risk factor in benign paroxysmal positional vertigo, although effect of its elimination on recurrence reduction remains unknown. To determine the effect of vitamin D supplementation in preventing recurrence of benign paroxysmal positional vertigo patients with vitamin D deficiency using a meta-analysis study. We searched and retrieved relevant articles from several databases, then used the Cochrane evaluation system or Methodological Index for Non-Randomized Studies (MINORS) to assess the quality of studies. We adopted risk-ratio (RR) with corresponding 95% confidence interval (CI) to determine effect sizes, and further performed statistical analyses under a randomized- or fixed-effects model. Seven studies, comprising 602 and 731 participants in the case and control group respectively, met our inclusion criteria, and were therefore included in the meta-analysis. Assessment based on Cochrane evaluation system or MINORS revealed that most of the studies had high quality. Moreover, the randomized- model revealed that the vitamin D supplementation group had a lower recurrence rate than the control group which did not accepted vitamin D supplementation (RR = 0.41, 95% CI = 0.26–0.65, p < 0.01). Overall, these findings indicate that vitamin D supplementation can significantly lower recurrence in benign paroxysmal positional vertigo and vitamin D deficiency.

Prevention of Recurrent Benign Paroxysmal Positional Vertigo: The Role of Combined Supplementation with Vitamin D and Antioxidants

“…This evidence and the outcomes of some recent trials [ 17 , 18 , 19 , 20 , 41 ] and meta-analysis [ 22 , 42 ] support the therapeutic effectiveness of the correction of hypovitaminosis D in patients with recurrent BPPV.…”

Vitamin D and homocysteine in benign paroxysmal positional vertigo

“…Головная боль и головокружение активным наблюдением и терапией может улучшить исходы ДППГ за счет снижения частоты рецидивов. Здесь необходимо отметить, что в 2020 г. были опубликованы результаты систематического анализа, демонстрирующего, что прием препаратов витамина D снижает риск рецидивирования ДППГ [11].…”

“…Jeong et al опубликовали работу, продемонстрировавшую более низкие уровни витамина D среди пациентов с ДППГ, чем в группе контроля [10], при этом дефицит активных форм витамина D является сильным предиктором развития ДППГ. В другом систематическом обзоре продемонстрирован эффект заместительной терапии на рецидивирование ДППГ [11].…”

Nutraceuticals for Peripheral Vestibular Pathology: Properties, Usefulness, Future Perspectives and Medico-Legal Aspects

“…Benign paroxysmal positional vertigo affects the inner ear and causes frequent and sudden attacks of positional vertigo (Table 1). Risk factors include advanced age, ear and dental surgery, vitamin D deficiency, menopause, and vascular disorders [11][12][13][14]. The main role is played by the otoconia, which may enter the semicircular canal and change position with head movements (canalithiasis theory) or adhere to the cupula of the canal and displace it (cupololithiasis theory) [9].…”

“…Vestibular maneuvers, vestibular suppressants. [7,[9][10][11][12][13][14][15][16] Vestibular neuritis Uncertain aetiology (e.g., vascular, viral, immunologic, or inflammatory).…”