Effect of Vitamin D supplementation on weight loss, glycemic indices, and lipid profile in obese and overweight women: A clinical trial study

Abstract

Introduction:Vitamin D (vit D) deficiency has defined as a health problem worldwide. World Health Organization (WHO) has declared that obesity is an epidemic of the 21st century. Previous studies have shown that obesity may increase the risk of Vit D deficiency. Furthermore, other studies have demonstrated that vit D insufficiency was accompanied with higher risk of type 2 diabetes, cardiovascular diseases, hypertension, and obesity. The aim of this study was to survey the effect of vit D supplementation on weight loss among overweight and obese women aged 20–40 years in Isfahan.Methods:This double-blind clinical trial was done on 50 overweight and obese women who were divided into two groups, in which one group received vit D supplements and the other group received placebo. Intervention group received vit D with dozes 50,000 IU/w for 6 weeks. The levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), fasting blood sugar (FBS), insulin (ins), homeostasis model assessment of ins resistance (IR), C-reactive protein (CRP), height, weight (WT), waist circumference (WC), hip circumference (HC), and blood pressure (BP) were measured before and after intervention.Results:After using vit D supplementation for 6 weeks, WT, WC, and body mass index (BMI) were decreased significantly and serum vit D increased significantly compared to control group (P < 0.001). Other factors including TC, TG, LDL-c, HDL-c, FBS, CRP, ins, IR, and waist to hip ratio (WHR) did not change significantly (P > 0.05).Conclusions:After 6 weeks of intervention, the means of WT, BMI, WC, and HC decreased significantly. Previous studies have shown that vit D deficiency was more prevalence in obese people and there was an inverse association among vit D with BMI and WC. The relationship between vit D and lipid profiles such as glycemic indexes, anthropometric indexes, CRP, and BP is not clear and needs more study in the future.

Vitamin D Insufficiency Reduces Grip Strength, Grip Endurance and Increases Frailty in Aged C57Bl/6J Mice

“…Vitamin D has previously been identified as a contributing factor during weight loss [ 23 , 24 ]. We therefore set out to determine if body weight and body composition were altered by changes in vitamin D status in aged mice.…”

Tuning Adipogenic Differentiation in ADSCs by Metformin and Vitamin D: Involvement of miRNAs

“…Metformin is a well-known drug used in the management of obesity, for its capability in reducing body weight in obese patients [ 35 , 36 ]. In addition, vitamin D supplementation has been shown to induce a decrease in weight and body mass index (BMI), reducing the risk of developing type 2 diabetes, cardiovascular diseases, and hypertension [ 37 ]. Furthermore, it is demonstrated that obesity is associated with low levels of circulating vitamin D, and with a reduced activity of CYP450 involved in its activation [ 38 , 39 , 40 ].…”

Serum 25-hydroxyvitamin D level in relation to weight change and the risk of weight gain in adults of normal weight at baseline: the Norwegian HUNT cohort study

“…Vitamin D might have a preventive effect on adiposity but no treatment effect on overweight and obesity. [14][15][16][17][18] Therefore, our study only selected adults who had a normal weight at baseline. Our findings of the inverse associations in adults of normal weight were consistent with those of a previous study of 4659 elderly women; in that study, women with higher baseline 25(OH)D level gained less weight over 4.5 years of follow-up in a subgroup of predominately normal weight at baseline.…”

“…13 Vitamin D may have a preventive effect on adiposity for individuals of normal weight but no treatment effect for the already overweight or obese individuals. [14][15][16][17][18] Thus, the objective of this study was to investigate the relationship of serum 25(OH) D level with weight change and the risk of weight gain among adults with normal weight at baseline who participated in the Nord-Trøndelag Health Study (HUNT) and were followed up for over 11 years.…”

“…Randomised controlled trials (RCT) have in general shown no effect of vitamin D supplementation on weight change over time. [14][15][16][17][18] These trials have mostly been conducted in overweight or obese individuals. Only one large RCT showed that participants of normal weight who received a daily supplement of calcium and vitamin D experienced significantly lower average annual weight gain and a lower risk of weight gain over 7 years of follow-up.…”