Effect of vitamin D supplementation on insulin resistance in type 2 DM subjects in Lagos, Nigeria

Anyanwu, Anthony; Fasanmade, Adetola; Coker, H. A. B.; Ohwovoriole, A.E

doi:10.1530/endoabs.44.p90

Cited by 2 publications

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“…9,10 This study found that 20,000 IU 25-hydroxy cholecalciferol (vitamin D3) supplementation at every 5 th day for 12 weeks effectively (P=.000) increased the 25 (OH) D3 level from baseline to end line(14.5±6.1 ng/mL to 35.8±7.5 ng/mL). Moreover, end line 25-hydroxyvitamin D levels were significantly higher in the treatment group as compared to placebo (treatment: 35.8 ±7.5 ng/mL and placebo: 20.05±5.2 ng/mL, p=0.001).Several studies also showed similar results by Tang H etal(2018) 11 (baseline: 41.16 nmol/L versus end line: 82.22 nmol/L); Ryu et al 12 (35.4 ± 8.5 ng/mL vs. 18.4 ± 7.3 ng/mL, p < 0.001); Anyanwu A C 13 . Mean FBG gradually decreased (P<0.001) from baseline 10.9 ng/ml (±3.5) to the end line 8.42 (±1.7).…”

Section: Discussionsupporting

confidence: 64%

“…In contrast, SOD have positive associations of changing Vitamin D level over 3-months intervention. Non-significant changes in the mean FBS level after 12 weeks of supplementation in the treatment group compared to the placebo also reported in other studies by Anyanwu et al, 2017; Rashidi et al, 2016 13,14. Both SOD and MDA have been considered as biological markers of oxidative stress.…”

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confidence: 79%

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Vitamin D Supplementation in Alleviation of Oxidative Stress among Type 2 Diabetics

Begum¹,

Kawser²,

Sadi³

et al. 2023

BJMAS

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Globally diabetes mellitus (T2DM) is a burning issue. Prediction of global estimation that the proportion of diabetes with adult will increase 69% for the year 2030. Hans Selye, the Canadian physiologist, was the first scientist to study the effects of psychological stress on the human body in 1936.Diabetic patients are in a state of high oxidative stress which leading to impaired glucose homeostasis, insulin insufficiency, and other complications.: A randomized controlled trial was conducted to see the effect of the vitamin D supplementation on oxidative stress in vitamin D deficientT2DM patients. In this study, a total of 124 T2DM patients were randomly enrolled, among them Treatment group 61 and placebo 63. In treatment group received 20,000IU vitamin D every 5thDay for three months in addition to regular treatment. Analysis of fasting plasma glucose (FPG), Vitamin D 25(OH)2, malondialdehyde (MDA) and superoxide dismutase (SOD) have been estimated both at the time of study recruitment, at 6th weeks and after 12-weeks of vitamin D supplementation (endline). Present study showed after vitamin D supplementation, baseline mean FBG gradually significantly (P<0.001) decreased at the end line in treatment group as compared to placebo. All biochemical indices by P- trend like FBG, vitamin D, MDA and SOD were significantly different (P<0.05). Whenever, consider between groups vitamin D increased (P<0.05) and FBG decreased significantly (P<0.05) in treatment group as compared to placebo. However, no significant impact on socio-demography variables, vitamin D and Stress-related characteristics between treatment and control groups after vitamin D supplementation as those variables are somewhat independent (p>0.05) both at baseline and end line. The results were considered significant at P<0.05. The statistical calculations were done using SPSS version 26 software. A strong positive co-relation between diabetes and oxidative stress were observed in this study and showed beneficial impact of vitamin D supplementation to reduce oxidative stress those who were vitamin D deficient.

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Section: Discussionsupporting

confidence: 64%

supporting

confidence: 79%

Vitamin D Supplementation in Alleviation of Oxidative Stress among Type 2 Diabetics

Begum¹,

Kawser²,

Sadi³

et al. 2023

BJMAS

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“…Characteristics of the included studies are summarized in Table 1. 31 studies were conducted in Asia [24,, 9 in Europe [23,27,[69][70][71][72][73][74], 3 in America [75][76][77], 1 in Africa [78], 1 in Australia [26] and 1 was conducted in 33 different countries [37]. A total of 4313 participants with type 2 diabetes were included in the current study, 2164 represented the intervention group and 2149 represented the control group.…”

Section: Study Characteristicsmentioning

confidence: 99%

What is the impact of vitamin D supplementation on glycemic control in people with type-2 diabetes: a systematic review and meta-analysis of randomized controlled trails

et al. 2023

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Background There is conflicting evidence on the effect of vitamin D on glycemic control. Therefore, in the current meta-analyses, we aimed to assess the effect of vitamin D supplementation on the glycemic control of type 2 diabetes (T2D) patients. Methods We conducted a comprehensive search in electronic databases including; PubMed/Medline, Web of Science, Scopus, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and NIH’s Clinical Trials Registry, from the inception of each database up to January first, 2021. Results A total of 46 randomized controlled trials (RCTs) consisting of 2164 intervention subjects and 2149 placebo controls were included in this meta-analysis. Pooled analyses for HbA1c showed a significant change between the intervention and placebo group, the weighted mean difference (WMD)(95% confidence interval(CI)) was -0.20%(-0.29, -0.11) with P < 0.001. Analyses for assessing changes in FPG found a significant reduction in the intervention group after vitamin D supplementation, the WMD (95%CI) was -5.02 mg/dl (-6.75,-3.28) with P < 0.001. The result of pooled analyses for HOMA-IR revealed a significant change between the intervention and control group, the WMD (95%CI) was -0.42(-0.76, -0.07) with P = 0.019. The subgroup analyses showed the most efficacy in a higher dose and short intervention period and in subjects with deficient vitamin D status. Conclusion Vitamin D supplementation might be beneficial for the reduction of FPG, HbA1c, and HOMA-IR in type 2 diabetes patients with deficient vitamin D status. This effect was especially prominent when vitamin D was given in large doses and for a short period of time albeit with substantial heterogeneity between studies and a probability of publication bias.

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Effect of vitamin D supplementation on insulin resistance in type 2 DM subjects in Lagos, Nigeria

Cited by 2 publications

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Vitamin D Supplementation in Alleviation of Oxidative Stress among Type 2 Diabetics

Vitamin D Supplementation in Alleviation of Oxidative Stress among Type 2 Diabetics

What is the impact of vitamin D supplementation on glycemic control in people with type-2 diabetes: a systematic review and meta-analysis of randomized controlled trails

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